Kinetic Modeling of Fluorotyrosine Uptake View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1993

AUTHORS

K. Wienhard , K. Herholz , H. H. Coenen , J. Rudolf , P. Kling , G. Stöcklin , W.-D. Heiss

ABSTRACT

L-(2-F-18)fluorotyrosine (F-Tyr) shown recently to be a tracer of cerebral protein synthesis in the mouse brain has several promising features as a PET tracer in humans: it penetrates easily into the brain, while almost no metabolites are found in brain tissue; the rather long half-life of fluor-18 permits to follow the uptake until accumulation becomes linear. Therefore, F-Tyr accumulation was studied for the first time in 15 patients with various brain tumors. Curve fitting to 2-hour F-Tyr accumulation data indicated a three tissue compartment (5 kinetic constants) model to be better suited for tumor tissue than a 3 rate constant approach. Increased uptake of F-Tyr in tumors was due to two times higher transport rates while the rate constants describing irreversible incorporation were on average decreased in tumors. More... »

PAGES

133-147

References to SciGraph publications

Book

TITLE

PET Studies on Amino Acid Metabolism and Protein Synthesis

ISBN

978-94-010-4706-7
978-94-011-1620-6

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-94-011-1620-6_9

DOI

http://dx.doi.org/10.1007/978-94-011-1620-6_9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1000230175


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