Process Technology and Process Integration in the Preparation of Penicillins View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2001

AUTHORS

L. A. M. van der Wielen , M. Ottens , A. J. J. Straathof

ABSTRACT

The antibiotic penicillin G (Pen G) is the most common raw material for semisynthetic β-lactam antibiotics. Key-intermediate for β-lactam antibiotics is 6-6-aminopenicillanic acid (APA), the β-lactam nucleus, which has a worldwide annual production volume of approximately 10,000 tons. Pen G is produced fermentatively by adding phenylacetic acid (PAA) to a crude fermentation broth. Pen G is converted, either chemically or enzymatically, to APA and PAA. Coupling chemically or enzymatically different side chains to APA can yield a wide range of semisynthetic penicillins with different specificities and stabilities. Examples of bulk semisynthetic antibiotics are Amoxicillin (Amox) and Ampicillin (Ampi) (Van de Sandt and De Vroom, 2000; Bruggink et al., 1998). These antibiotics have market sales worth of ca. $ 3 billion per year as bulk-formulated drug; further market information is given in chapter 1. Figure IV.1 shows a general overview of the route for synthesis of Amox. More... »

PAGES

150-205

Book

TITLE

Synthesis of β-Lactam Antibiotics

ISBN

978-94-010-3851-5
978-94-010-0850-1

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-94-010-0850-1_4

DOI

http://dx.doi.org/10.1007/978-94-010-0850-1_4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1047296105


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