Ribonuclease T1: Mechanism of Specific Guanine Recognition and RNA Hydrolysis View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1983

AUTHORS

Udo Heinemann , Wolfram Saenger

ABSTRACT

The crystal structure analysis of the complex RNase T1 • 2’-guanylic acid has provided insight into specific protein-nucleic acid interaction and into the mechanism of RNA hydrolysis catalyzed by RNase T1. Recognition of guanine is via hydrogen bonding of main chain dipeptide Asn43-Asn44 to O6 and N1-H of the base and additional stacking of Tyr45 with the guanine heterocycle and of Tyr42 with guanine O6. RNA hydrolysis is initiated by removal of a proton from O2, H by G1u58 followed by formation of a cyclic 2’,3’-guanylic acid, assisted by Arg77 and by His92. In a second step the cyclic intermediate is hydrolized by water to yield an RNA fragment with terminal 3’-guanylic acid. More... »

PAGES

265-276

Book

TITLE

Nucleic Acids: The Vectors of Life

ISBN

978-94-009-7227-8
978-94-009-7225-4

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-94-009-7225-4_19

DOI

http://dx.doi.org/10.1007/978-94-009-7225-4_19

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1051886029


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Max Planck Institute for Experimental Medicine", 
          "id": "https://www.grid.ac/institutes/grid.419522.9", 
          "name": [
            "Max-Planck Institut f\u00fcr experimentelle Medizin, Hermann-Rein-Str. 3, 3400\u00a0G\u00f6ttingen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Heinemann", 
        "givenName": "Udo", 
        "id": "sg:person.01000563275.06", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01000563275.06"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Max Planck Institute for Experimental Medicine", 
          "id": "https://www.grid.ac/institutes/grid.419522.9", 
          "name": [
            "Max-Planck Institut f\u00fcr experimentelle Medizin, Hermann-Rein-Str. 3, 3400\u00a0G\u00f6ttingen, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Saenger", 
        "givenName": "Wolfram", 
        "id": "sg:person.01246060011.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01246060011.82"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/0014-5793(78)80193-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000002816"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/297162a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007660404", 
          "https://doi.org/10.1038/297162a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/299564a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010021927", 
          "https://doi.org/10.1038/299564a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/290744a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019356082", 
          "https://doi.org/10.1038/290744a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.57.2.250", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024116524"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1874-6047(08)60285-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029457014"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0968-0004(83)90065-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030590243"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0968-0004(83)90065-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030590243"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1432-1033.1980.tb04774.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033157031"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/298443a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039867166", 
          "https://doi.org/10.1038/298443a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/298443a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039867166", 
          "https://doi.org/10.1038/298443a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/299027a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039891089", 
          "https://doi.org/10.1038/299027a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/299027a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039891089", 
          "https://doi.org/10.1038/299027a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi00568a003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055181082"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi00577a021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055181394"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1983", 
    "datePublishedReg": "1983-01-01", 
    "description": "The crystal structure analysis of the complex RNase T1 \u2022 2\u2019-guanylic acid has provided insight into specific protein-nucleic acid interaction and into the mechanism of RNA hydrolysis catalyzed by RNase T1. Recognition of guanine is via hydrogen bonding of main chain dipeptide Asn43-Asn44 to O6 and N1-H of the base and additional stacking of Tyr45 with the guanine heterocycle and of Tyr42 with guanine O6. RNA hydrolysis is initiated by removal of a proton from O2, H by G1u58 followed by formation of a cyclic 2\u2019,3\u2019-guanylic acid, assisted by Arg77 and by His92. In a second step the cyclic intermediate is hydrolized by water to yield an RNA fragment with terminal 3\u2019-guanylic acid.", 
    "editor": [
      {
        "familyName": "Pullman", 
        "givenName": "Bernard", 
        "type": "Person"
      }, 
      {
        "familyName": "Jortner", 
        "givenName": "Joshua", 
        "type": "Person"
      }
    ], 
    "genre": "chapter", 
    "id": "sg:pub.10.1007/978-94-009-7225-4_19", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": {
      "isbn": [
        "978-94-009-7227-8", 
        "978-94-009-7225-4"
      ], 
      "name": "Nucleic Acids: The Vectors of Life", 
      "type": "Book"
    }, 
    "name": "Ribonuclease T1: Mechanism of Specific Guanine Recognition and RNA Hydrolysis", 
    "pagination": "265-276", 
    "productId": [
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/978-94-009-7225-4_19"
        ]
      }, 
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "f727b46f1f28b12aea4e65ebfecb83eb0ad0942b9671b66f106c09b0d1052781"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1051886029"
        ]
      }
    ], 
    "publisher": {
      "location": "Dordrecht", 
      "name": "Springer Netherlands", 
      "type": "Organisation"
    }, 
    "sameAs": [
      "https://doi.org/10.1007/978-94-009-7225-4_19", 
      "https://app.dimensions.ai/details/publication/pub.1051886029"
    ], 
    "sdDataset": "chapters", 
    "sdDatePublished": "2019-04-16T00:52", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8700_00000275.jsonl", 
    "type": "Chapter", 
    "url": "http://link.springer.com/10.1007/978-94-009-7225-4_19"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-94-009-7225-4_19'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-94-009-7225-4_19'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-94-009-7225-4_19'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-94-009-7225-4_19'


 

This table displays all metadata directly associated to this object as RDF triples.

118 TRIPLES      23 PREDICATES      39 URIs      20 LITERALS      8 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/978-94-009-7225-4_19 schema:about anzsrc-for:06
2 anzsrc-for:0601
3 schema:author N644da5678e714c70af833529769bd277
4 schema:citation sg:pub.10.1038/290744a0
5 sg:pub.10.1038/297162a0
6 sg:pub.10.1038/298443a0
7 sg:pub.10.1038/299027a0
8 sg:pub.10.1038/299564a0
9 https://doi.org/10.1016/0014-5793(78)80193-8
10 https://doi.org/10.1016/0968-0004(83)90065-8
11 https://doi.org/10.1016/s1874-6047(08)60285-1
12 https://doi.org/10.1021/bi00568a003
13 https://doi.org/10.1021/bi00577a021
14 https://doi.org/10.1073/pnas.57.2.250
15 https://doi.org/10.1111/j.1432-1033.1980.tb04774.x
16 schema:datePublished 1983
17 schema:datePublishedReg 1983-01-01
18 schema:description The crystal structure analysis of the complex RNase T1 • 2’-guanylic acid has provided insight into specific protein-nucleic acid interaction and into the mechanism of RNA hydrolysis catalyzed by RNase T1. Recognition of guanine is via hydrogen bonding of main chain dipeptide Asn43-Asn44 to O6 and N1-H of the base and additional stacking of Tyr45 with the guanine heterocycle and of Tyr42 with guanine O6. RNA hydrolysis is initiated by removal of a proton from O2, H by G1u58 followed by formation of a cyclic 2’,3’-guanylic acid, assisted by Arg77 and by His92. In a second step the cyclic intermediate is hydrolized by water to yield an RNA fragment with terminal 3’-guanylic acid.
19 schema:editor N6f57df9d527144aaae6017e934659cf9
20 schema:genre chapter
21 schema:inLanguage en
22 schema:isAccessibleForFree false
23 schema:isPartOf Nb8269923997d47cca95be583edb20ef9
24 schema:name Ribonuclease T1: Mechanism of Specific Guanine Recognition and RNA Hydrolysis
25 schema:pagination 265-276
26 schema:productId N2d1643a7d9bd48998039a192f5f32179
27 N42d845e65b88489dab7ca5bbec17ece0
28 Na8590eaee2c04746a81dbe8006a7276d
29 schema:publisher N81c8d4318ea54b57b555f77c168bc0b4
30 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051886029
31 https://doi.org/10.1007/978-94-009-7225-4_19
32 schema:sdDatePublished 2019-04-16T00:52
33 schema:sdLicense https://scigraph.springernature.com/explorer/license/
34 schema:sdPublisher N151038050f5e475ebba7efd822336e53
35 schema:url http://link.springer.com/10.1007/978-94-009-7225-4_19
36 sgo:license sg:explorer/license/
37 sgo:sdDataset chapters
38 rdf:type schema:Chapter
39 N151038050f5e475ebba7efd822336e53 schema:name Springer Nature - SN SciGraph project
40 rdf:type schema:Organization
41 N28653ebe28c2465cbed0ff37252b2b2b schema:familyName Jortner
42 schema:givenName Joshua
43 rdf:type schema:Person
44 N2d1643a7d9bd48998039a192f5f32179 schema:name dimensions_id
45 schema:value pub.1051886029
46 rdf:type schema:PropertyValue
47 N42d845e65b88489dab7ca5bbec17ece0 schema:name doi
48 schema:value 10.1007/978-94-009-7225-4_19
49 rdf:type schema:PropertyValue
50 N54a7b5df2ec1475aafb82f9f02d9fbe0 schema:familyName Pullman
51 schema:givenName Bernard
52 rdf:type schema:Person
53 N644da5678e714c70af833529769bd277 rdf:first sg:person.01000563275.06
54 rdf:rest N6b57dedbad8940cb895963f4daa635bb
55 N6b57dedbad8940cb895963f4daa635bb rdf:first sg:person.01246060011.82
56 rdf:rest rdf:nil
57 N6f57df9d527144aaae6017e934659cf9 rdf:first N54a7b5df2ec1475aafb82f9f02d9fbe0
58 rdf:rest N9db4ba9ed10a42168f5db65aaf109019
59 N81c8d4318ea54b57b555f77c168bc0b4 schema:location Dordrecht
60 schema:name Springer Netherlands
61 rdf:type schema:Organisation
62 N9db4ba9ed10a42168f5db65aaf109019 rdf:first N28653ebe28c2465cbed0ff37252b2b2b
63 rdf:rest rdf:nil
64 Na8590eaee2c04746a81dbe8006a7276d schema:name readcube_id
65 schema:value f727b46f1f28b12aea4e65ebfecb83eb0ad0942b9671b66f106c09b0d1052781
66 rdf:type schema:PropertyValue
67 Nb8269923997d47cca95be583edb20ef9 schema:isbn 978-94-009-7225-4
68 978-94-009-7227-8
69 schema:name Nucleic Acids: The Vectors of Life
70 rdf:type schema:Book
71 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
72 schema:name Biological Sciences
73 rdf:type schema:DefinedTerm
74 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
75 schema:name Biochemistry and Cell Biology
76 rdf:type schema:DefinedTerm
77 sg:person.01000563275.06 schema:affiliation https://www.grid.ac/institutes/grid.419522.9
78 schema:familyName Heinemann
79 schema:givenName Udo
80 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01000563275.06
81 rdf:type schema:Person
82 sg:person.01246060011.82 schema:affiliation https://www.grid.ac/institutes/grid.419522.9
83 schema:familyName Saenger
84 schema:givenName Wolfram
85 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01246060011.82
86 rdf:type schema:Person
87 sg:pub.10.1038/290744a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019356082
88 https://doi.org/10.1038/290744a0
89 rdf:type schema:CreativeWork
90 sg:pub.10.1038/297162a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007660404
91 https://doi.org/10.1038/297162a0
92 rdf:type schema:CreativeWork
93 sg:pub.10.1038/298443a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039867166
94 https://doi.org/10.1038/298443a0
95 rdf:type schema:CreativeWork
96 sg:pub.10.1038/299027a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039891089
97 https://doi.org/10.1038/299027a0
98 rdf:type schema:CreativeWork
99 sg:pub.10.1038/299564a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010021927
100 https://doi.org/10.1038/299564a0
101 rdf:type schema:CreativeWork
102 https://doi.org/10.1016/0014-5793(78)80193-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000002816
103 rdf:type schema:CreativeWork
104 https://doi.org/10.1016/0968-0004(83)90065-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030590243
105 rdf:type schema:CreativeWork
106 https://doi.org/10.1016/s1874-6047(08)60285-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029457014
107 rdf:type schema:CreativeWork
108 https://doi.org/10.1021/bi00568a003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055181082
109 rdf:type schema:CreativeWork
110 https://doi.org/10.1021/bi00577a021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055181394
111 rdf:type schema:CreativeWork
112 https://doi.org/10.1073/pnas.57.2.250 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024116524
113 rdf:type schema:CreativeWork
114 https://doi.org/10.1111/j.1432-1033.1980.tb04774.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1033157031
115 rdf:type schema:CreativeWork
116 https://www.grid.ac/institutes/grid.419522.9 schema:alternateName Max Planck Institute for Experimental Medicine
117 schema:name Max-Planck Institut für experimentelle Medizin, Hermann-Rein-Str. 3, 3400 Göttingen, Germany
118 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...