Transforming Genes of Human Malignancies View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1985

AUTHORS

Alessandra Eva , Stuart A. Aaronson , Steven R. Tronick

ABSTRACT

Knowledge of the mechanisms by which normal cells become converted to the malignant state has increased within the past few years due to a series of remarkable discoveries. A wide variety of human tumors have been shown to possess discrete genetic sequences capable of inducing the transformation of appropriate assay cells. These genes were subsequently found to be the homologues of the cell-derived oncogene sequences responsible for the transforming activity of a group of well-characterized RNA tumor viruses. Investigations of the specific chromosomal translocations that occur in certain human tumors has also revealed that the movement of a specific cellular gene, again a homologue of a retroviral transforming gene, to a new regulatory environment alters its expression, thus contributing to tumor development. More... »

PAGES

43-57

Book

TITLE

Interrelationship Among Aging, Cancer and Differentiation

ISBN

978-94-010-8913-5
978-94-009-5466-3

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-94-009-5466-3_6

DOI

http://dx.doi.org/10.1007/978-94-009-5466-3_6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1016357828


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