New Agents for Probing Glucose Turnover and Receptor Densities in the Brain View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1985

AUTHORS

G. Kloster , G. Stöcklin

ABSTRACT

In vivo functional imaging of the brain has, in contrast to that of other organs like heart or liver, only developed in the last decade. This is mainly due to a special feature of brain physiology, namely the blood-brain-barrier (BBB). BBB selectively restricts the access to the brain of most non-lipophilic substances borne in blood; only a relatively small number of vital substrates are transported into the brain by specialized carrier system. Thus, most of the radio-pharmaceuticals available in the early days of nuclear medicine were excluded from the brain. Only in areas with a destroyed BBB (some tumours etc) was it possible to observe measurable concentrations e.g. of Tc99m-compounds (1). This situation has dramatically changed recently with the application of metabolic tracers or analogs labelled with short-lived “organic” radionuclides. These radionuclides that form stable covalent binds to carbon, either the positron emitters 11C (T1/2= 98 min), 18F (T1/2= 110 min) and 75Br (T1/2= 98 min) or the single photon emitter 123I (T1/2= 13.3 h) can be introduced into most of the compounds important for the characteristic metabolism or function of the brain with acceptable alterations in their physico-chemical behaviour (2). They also lend themselves to 3-dimensional imaging, the positron emitters to positron-emission computed tomography (PECT) and the single photon emitters to single photon emission computed tomography (SPECT). More... »

PAGES

89-121

Book

TITLE

Progress in radiopharmacology 1985

ISBN

978-94-010-8727-8
978-94-009-5028-3

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-94-009-5028-3_6

DOI

http://dx.doi.org/10.1007/978-94-009-5028-3_6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1034792174


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