Effects of mononuclear phagocytes and their secretory products on vascular endothelium View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1985

AUTHORS

M. P. Bevilacqua , J. S. Pober , R. S. Cotran , M. A. Gimbrone

ABSTRACT

There is increasing evidence that interactions between mononuclear phagocytes and vascular endothelium are involved in a variety of pathological processes. In its unique anatomic location, the endothelium could serve a regulatory role in the trafficking of blood monocytes across the vascular wall. Once localized at a particular site, monocytes and macrophages may potentially exert a broad spectrum of effects on vascular wall cells through the elaboration of biologically active products (Table I). In this paper we will first briefly review studies from our laboratory and others on the role of monocyte-macrophage-derived products which affect the growth of new blood vessels (neovascularization) and the proliferation of vascular smooth muscle cells and fibroblasts. We will then present results of current work on the induction of endothelial cell procoagulant activity (PCA) by human monocyte-derived interleukin 1 (IL-1). Finally, we will report certain recent observations on direct cellular interactions between mononuclear phagocytes and vascular endo­thelium in vitro. More... »

PAGES

747-753

References to SciGraph publications

Book

TITLE

Mononuclear Phagocytes

ISBN

978-94-010-8723-0
978-94-009-5020-7

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-94-009-5020-7_77

DOI

http://dx.doi.org/10.1007/978-94-009-5020-7_77

DIMENSIONS

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