Interferon and Tumor Necrosis Factor Alter the Phospholipid Metabolism in Friend Leukemia Cell Tumors in Mice View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1987

AUTHORS

E. Proietti , F. Belardelli , G. Carpinelli , M. Di Vito , I. Gresser , W. Fiers , J. Tavernier , F. Podo

ABSTRACT

Interferon (IFN) has been shown to inhibit the growth of different tumors in experimental animals (reviewed in 1 and 2) and it is currently used to treat some patients with cancer in clinical trials. However the mechanisms of antitumor effects of IFN are still unknown (2). We have previously shown that administration of highly purified α/β IFN was equally effective in inhibiting tumor growth in mice injected with either IFN-sensitive or IFN-resistant Friend leukemia cells (3,4). These data suggested that the antitumor effects of IFN in this system were not due to a direct effect of IFN on tumor cells but that these effects were in some way host-mediated (4). Daily injection of IFN into FLC tumors implanted subcutaneously (s.c.) caused an arrest of tumor growth and tumor necrosis and resulted in a complete tumor regression in some mice transplanted with either IFN-sensitive or IFN-resistant FLC (5). More... »

PAGES

281-285

Book

TITLE

The Biology of the Interferon System 1986

ISBN

978-94-010-8084-2
978-94-009-3543-3

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-94-009-3543-3_39

DOI

http://dx.doi.org/10.1007/978-94-009-3543-3_39

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1035812291


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