Studies on the Expression of Spontaneous Interferon-Like Activity in Mouse Peritoneal Cells View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1987

AUTHORS

F. Belardelli , S. Gessani , P. Borghi , E. Proietti , D. Boraschi , Y. Kawade , I. Gresser

ABSTRACT

Macrophages exert important functions in non specific natural resistance to virus infections (1–3). Several animal viruses do not multiply in macrophages when these cells are first placed in culture suggesting that in vivo macrophages may limit virus spread by inhibiting virus multiplication. The resistance of resting mouse peritoneal macrophages to vescicular stomatitis virus (VSV) and encephalomyocarditis virus (EMCV) can be abolished by injection of mice with sheep antibody to interferon α/β (4). An inverse correlation was observed between the intracellular levels of (2′–5′)oligo-adenylate (2–5A) synthetase activity in peritoneal macrophages and the permissivity of these cells for VSV (5). Thus, the levels of 2–5A synthetase activity in peritoneal macrophages from mice injected with antibody to interferon were markedly lower with respect to macrophages freshly harvested from control mice (5). More... »

PAGES

139-146

References to SciGraph publications

Book

TITLE

The Biology of the Interferon System 1986

ISBN

978-94-010-8084-2
978-94-009-3543-3

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-94-009-3543-3_20

DOI

http://dx.doi.org/10.1007/978-94-009-3543-3_20

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1049063194


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