Differential Structures and Activities of Three IFN α2 Variants Departing Only at Two Amino Acid Positions View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1987

AUTHORS

A. v. Gabain , M. Ohlsson , E. Holmgren , S. Josephsson , S. S. Alkan , E. Lundgren

ABSTRACT

Almost 40 human interferon (IFN) a sequences have been derived from various c-DNA and chromosomal libraries (1). Cataloguing DNA segments containing IFN sequences, made it possible to distinguish 18 IFN α related loci in the chromosome (1,2,3). A genetic study based on 25 families, has restricted the number of different IFN α loci to about 17 (4) and has revealed a high degree of polymorphism in the human IFN a loci. For many of the known IFN α sequences it is not possible to decide whether they represent alleles or different loci, when they are compared to each other. More... »

PAGES

11-18

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-94-009-3543-3_2

DOI

http://dx.doi.org/10.1007/978-94-009-3543-3_2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1046916361


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Inst. of Appl. Cell and Molec. Biology, University of Ume\u00e5, S-901 87, Ume\u00e5, Sweden", 
          "id": "http://www.grid.ac/institutes/grid.12650.30", 
          "name": [
            "Dept of Bacteriology, Karolinska Institute, S-104 01, Stockholm, Sweden", 
            "Inst. of Appl. Cell and Molec. Biology, University of Ume\u00e5, S-901 87, Ume\u00e5, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "v. Gabain", 
        "givenName": "A.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Inst. of Appl. Cell and Molec. Biology, University of Ume\u00e5, S-901 87, Ume\u00e5, Sweden", 
          "id": "http://www.grid.ac/institutes/grid.12650.30", 
          "name": [
            "Inst. of Appl. Cell and Molec. Biology, University of Ume\u00e5, S-901 87, Ume\u00e5, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ohlsson", 
        "givenName": "M.", 
        "id": "sg:person.01101731641.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01101731641.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "KabiGen AB, S-112 87, Stockholm, Sweden", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "KabiGen AB, S-112 87, Stockholm, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Holmgren", 
        "givenName": "E.", 
        "id": "sg:person.01245157525.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01245157525.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "KabiGen AB, S-112 87, Stockholm, Sweden", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "KabiGen AB, S-112 87, Stockholm, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Josephsson", 
        "givenName": "S.", 
        "id": "sg:person.0633777363.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0633777363.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ciba Geigy Ltd., CH-4002, Basle, Switzerland", 
          "id": "http://www.grid.ac/institutes/grid.419481.1", 
          "name": [
            "Ciba Geigy Ltd., CH-4002, Basle, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Alkan", 
        "givenName": "S. S.", 
        "id": "sg:person.01233424705.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233424705.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Inst. of Appl. Cell and Molec. Biology, University of Ume\u00e5, S-901 87, Ume\u00e5, Sweden", 
          "id": "http://www.grid.ac/institutes/grid.12650.30", 
          "name": [
            "Inst. of Appl. Cell and Molec. Biology, University of Ume\u00e5, S-901 87, Ume\u00e5, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lundgren", 
        "givenName": "E.", 
        "id": "sg:person.0713005341.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0713005341.81"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "1987", 
    "datePublishedReg": "1987-01-01", 
    "description": "Almost 40 human interferon (IFN) a sequences have been derived from various c-DNA and chromosomal libraries (1). Cataloguing DNA segments containing IFN sequences, made it possible to distinguish 18 IFN \u03b1 related loci in the chromosome (1,2,3). A genetic study based on 25 families, has restricted the number of different IFN \u03b1 loci to about 17 (4) and has revealed a high degree of polymorphism in the human IFN a loci. For many of the known IFN \u03b1 sequences it is not possible to decide whether they represent alleles or different loci, when they are compared to each other.", 
    "editor": [
      {
        "familyName": "Cantell", 
        "givenName": "K.", 
        "type": "Person"
      }, 
      {
        "familyName": "Schellekens", 
        "givenName": "H.", 
        "type": "Person"
      }
    ], 
    "genre": "chapter", 
    "id": "sg:pub.10.1007/978-94-009-3543-3_2", 
    "isAccessibleForFree": false, 
    "isPartOf": {
      "isbn": [
        "978-94-010-8084-2", 
        "978-94-009-3543-3"
      ], 
      "name": "The Biology of the Interferon System 1986", 
      "type": "Book"
    }, 
    "keywords": [
      "amino acid positions", 
      "chromosomal library", 
      "\u03b1 locus", 
      "DNA segments", 
      "genetic studies", 
      "different loci", 
      "c-DNA", 
      "human interferon", 
      "loci", 
      "\u03b1 sequences", 
      "sequence", 
      "\u03b12 variants", 
      "chromosomes", 
      "IFN \u03b1", 
      "alleles", 
      "polymorphism", 
      "high degree", 
      "interferon", 
      "family", 
      "variants", 
      "library", 
      "activity", 
      "segments", 
      "structure", 
      "number", 
      "study", 
      "position", 
      "degree", 
      "differential structure"
    ], 
    "name": "Differential Structures and Activities of Three IFN \u03b12 Variants Departing Only at Two Amino Acid Positions", 
    "pagination": "11-18", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1046916361"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/978-94-009-3543-3_2"
        ]
      }
    ], 
    "publisher": {
      "name": "Springer Nature", 
      "type": "Organisation"
    }, 
    "sameAs": [
      "https://doi.org/10.1007/978-94-009-3543-3_2", 
      "https://app.dimensions.ai/details/publication/pub.1046916361"
    ], 
    "sdDataset": "chapters", 
    "sdDatePublished": "2022-09-02T16:10", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220902/entities/gbq_results/chapter/chapter_114.jsonl", 
    "type": "Chapter", 
    "url": "https://doi.org/10.1007/978-94-009-3543-3_2"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-94-009-3543-3_2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-94-009-3543-3_2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-94-009-3543-3_2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-94-009-3543-3_2'


 

This table displays all metadata directly associated to this object as RDF triples.

134 TRIPLES      22 PREDICATES      54 URIs      47 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/978-94-009-3543-3_2 schema:about anzsrc-for:06
2 anzsrc-for:0604
3 schema:author Nc488f5b84c664ccd9beb7609b757c382
4 schema:datePublished 1987
5 schema:datePublishedReg 1987-01-01
6 schema:description Almost 40 human interferon (IFN) a sequences have been derived from various c-DNA and chromosomal libraries (1). Cataloguing DNA segments containing IFN sequences, made it possible to distinguish 18 IFN α related loci in the chromosome (1,2,3). A genetic study based on 25 families, has restricted the number of different IFN α loci to about 17 (4) and has revealed a high degree of polymorphism in the human IFN a loci. For many of the known IFN α sequences it is not possible to decide whether they represent alleles or different loci, when they are compared to each other.
7 schema:editor N6e4be56b8d1b44aba069beef514449dc
8 schema:genre chapter
9 schema:isAccessibleForFree false
10 schema:isPartOf N6d07724134ef4ed1af10e5c36cea6d6b
11 schema:keywords DNA segments
12 IFN α
13 activity
14 alleles
15 amino acid positions
16 c-DNA
17 chromosomal library
18 chromosomes
19 degree
20 different loci
21 differential structure
22 family
23 genetic studies
24 high degree
25 human interferon
26 interferon
27 library
28 loci
29 number
30 polymorphism
31 position
32 segments
33 sequence
34 structure
35 study
36 variants
37 α locus
38 α sequences
39 α2 variants
40 schema:name Differential Structures and Activities of Three IFN α2 Variants Departing Only at Two Amino Acid Positions
41 schema:pagination 11-18
42 schema:productId N8bb0d6060929499b98e3ab2e2064d176
43 Nf57fb1d3f55c4e7bab400cc08486a55a
44 schema:publisher N8808f462afb44965a2b9ab9b4da336c4
45 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046916361
46 https://doi.org/10.1007/978-94-009-3543-3_2
47 schema:sdDatePublished 2022-09-02T16:10
48 schema:sdLicense https://scigraph.springernature.com/explorer/license/
49 schema:sdPublisher N1d4a3a80f40c4632bc7eda8e975b86c1
50 schema:url https://doi.org/10.1007/978-94-009-3543-3_2
51 sgo:license sg:explorer/license/
52 sgo:sdDataset chapters
53 rdf:type schema:Chapter
54 N0a14c74ebc3f4c1c95f3e07b57e72fe8 schema:familyName Cantell
55 schema:givenName K.
56 rdf:type schema:Person
57 N1d4a3a80f40c4632bc7eda8e975b86c1 schema:name Springer Nature - SN SciGraph project
58 rdf:type schema:Organization
59 N2f3a2f1f8f0a44e0b23cc45ce5cdff62 rdf:first sg:person.0633777363.78
60 rdf:rest N36f3e9b533e04b0a854f621be692e03b
61 N36f3e9b533e04b0a854f621be692e03b rdf:first sg:person.01233424705.11
62 rdf:rest Nee05211a33934e3580c78e548c6e7b8e
63 N3fc7d5f1dba94676b7a66f0620a81eb5 rdf:first sg:person.01101731641.11
64 rdf:rest Na82fecdebbf84cbb80b5ff3ae01bf6d5
65 N48c9312905e049ca873dd7b006efc9c8 rdf:first Nbe84e1c415444b4fb4876a8ef9860818
66 rdf:rest rdf:nil
67 N6d07724134ef4ed1af10e5c36cea6d6b schema:isbn 978-94-009-3543-3
68 978-94-010-8084-2
69 schema:name The Biology of the Interferon System 1986
70 rdf:type schema:Book
71 N6e4be56b8d1b44aba069beef514449dc rdf:first N0a14c74ebc3f4c1c95f3e07b57e72fe8
72 rdf:rest N48c9312905e049ca873dd7b006efc9c8
73 N8808f462afb44965a2b9ab9b4da336c4 schema:name Springer Nature
74 rdf:type schema:Organisation
75 N8bb0d6060929499b98e3ab2e2064d176 schema:name dimensions_id
76 schema:value pub.1046916361
77 rdf:type schema:PropertyValue
78 N969b2ddfde424fc69c9f196802e8a0f3 schema:affiliation grid-institutes:grid.12650.30
79 schema:familyName v. Gabain
80 schema:givenName A.
81 rdf:type schema:Person
82 Na82fecdebbf84cbb80b5ff3ae01bf6d5 rdf:first sg:person.01245157525.22
83 rdf:rest N2f3a2f1f8f0a44e0b23cc45ce5cdff62
84 Nbe84e1c415444b4fb4876a8ef9860818 schema:familyName Schellekens
85 schema:givenName H.
86 rdf:type schema:Person
87 Nc488f5b84c664ccd9beb7609b757c382 rdf:first N969b2ddfde424fc69c9f196802e8a0f3
88 rdf:rest N3fc7d5f1dba94676b7a66f0620a81eb5
89 Nee05211a33934e3580c78e548c6e7b8e rdf:first sg:person.0713005341.81
90 rdf:rest rdf:nil
91 Nf57fb1d3f55c4e7bab400cc08486a55a schema:name doi
92 schema:value 10.1007/978-94-009-3543-3_2
93 rdf:type schema:PropertyValue
94 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
95 schema:name Biological Sciences
96 rdf:type schema:DefinedTerm
97 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
98 schema:name Genetics
99 rdf:type schema:DefinedTerm
100 sg:person.01101731641.11 schema:affiliation grid-institutes:grid.12650.30
101 schema:familyName Ohlsson
102 schema:givenName M.
103 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01101731641.11
104 rdf:type schema:Person
105 sg:person.01233424705.11 schema:affiliation grid-institutes:grid.419481.1
106 schema:familyName Alkan
107 schema:givenName S. S.
108 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233424705.11
109 rdf:type schema:Person
110 sg:person.01245157525.22 schema:affiliation grid-institutes:None
111 schema:familyName Holmgren
112 schema:givenName E.
113 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01245157525.22
114 rdf:type schema:Person
115 sg:person.0633777363.78 schema:affiliation grid-institutes:None
116 schema:familyName Josephsson
117 schema:givenName S.
118 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0633777363.78
119 rdf:type schema:Person
120 sg:person.0713005341.81 schema:affiliation grid-institutes:grid.12650.30
121 schema:familyName Lundgren
122 schema:givenName E.
123 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0713005341.81
124 rdf:type schema:Person
125 grid-institutes:None schema:alternateName KabiGen AB, S-112 87, Stockholm, Sweden
126 schema:name KabiGen AB, S-112 87, Stockholm, Sweden
127 rdf:type schema:Organization
128 grid-institutes:grid.12650.30 schema:alternateName Inst. of Appl. Cell and Molec. Biology, University of Umeå, S-901 87, Umeå, Sweden
129 schema:name Dept of Bacteriology, Karolinska Institute, S-104 01, Stockholm, Sweden
130 Inst. of Appl. Cell and Molec. Biology, University of Umeå, S-901 87, Umeå, Sweden
131 rdf:type schema:Organization
132 grid-institutes:grid.419481.1 schema:alternateName Ciba Geigy Ltd., CH-4002, Basle, Switzerland
133 schema:name Ciba Geigy Ltd., CH-4002, Basle, Switzerland
134 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...