Some Freshly EBV-Transformed B-Cell Lines Lack Functional IFN-Receptors View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1987

AUTHORS

Erik Lundgren , Mona Lundström , Alex von Gabain

ABSTRACT

Various cell lines carrying the Epstein-Barr virus (EBV) genome differ in their responsiveness towards interferons (IFN). Among Burkitt’s lymphoma derived cell lines some are growth inhibited by IFN-α at very low concentrations (e.g. Daudi, P3HR-1), while others are resistant even at high concentrations (1, 2). Primary B-cells triggered to growth by EBV react in a complex pattern to IFN:s. Thus, the initial growth response, the increased antibody secretion and the immortalization event are all inhibited by IFN (3). However, once the cells have been immortalized, they are no longer affected by cell growth inhibition (3). More... »

PAGES

109-115

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-94-009-3543-3_16

DOI

http://dx.doi.org/10.1007/978-94-009-3543-3_16

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1038704426


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