Lymphoepithelial interactions associated with proximal colonic lymphoid tissue in the mouse View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1990

AUTHORS

S K Saxena , G A Perry , S S Joshi , J G Sharp

ABSTRACT

The proximal colon of the rodent contains an organized lymphoid nodule consistently located 25% of the distance from the cecum to the anus. We have undertaken a morphokinetic evaluation of crypts associated with this lymphoid tissue, as compared to crypts on adjacent plicae. Results demonstrated that the crypts associated with this lymphoid nodule are deeper, contain greater numbers of columnar and goblet cells and have a greater cell production than crypts of adjacent alymphoid plicae. The distribution of metaphases is shifted toward the upper part of lymphoid associated crypts and the binding of radiolabelled recombinant human urogastrone (rhUG/EGF) is greater even in mice treated with steroid to deplete the lymphoid elements. These results indicate a significant lymphoepithelial interaction associated with proximal colonic lymphoid tissue (PCLT), and suggest that this interaction may be mediated by a locally acting paracrine mechanism(s). More... »

PAGES

91-94

References to SciGraph publications

Book

TITLE

Advances in Mucosal Immunology

ISBN

978-94-010-7323-3
978-94-009-1848-1

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-94-009-1848-1_24

DOI

http://dx.doi.org/10.1007/978-94-009-1848-1_24

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1046859732


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