Cell adhesion molecules in autoimmune enteropathy View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1990

AUTHORS

S M Hill , P J Milla , T Casaseca , G F Bottazzo , R Mirakian

ABSTRACT

Adhesion to both haematopoetic and non-haematopoetic cells is an obligatory step in antigen presentation and effector cell function. Intercellular adhesion molecule-1 (ICAM-1) is a cell surface glcoprotein whose expression is up-regulated by cytokines in vitro and by inflammatory processes in vivo. It acts as a ligand for the lymphocyte function associated antigen (LFA-1), a molecule which is important in antigen dependent and antigen non-dependent T lymphocyte function. In addition, it plays a relevant role in the adhesion and function of essentially all leukocyte cell types (1). In the small intestine, ICAM-1 expression has been demonstrated in the lamina propria (LP) on most endothelial cells, on dendritic-like cells and macrophages, but it is generally absent on epithelial cells (2). Autoimmune enteropathy is clinically characterised by protracted diarrhoea, and the affected children have circulating autoantibodies to enterocytes. Examination of biopsy material has revealed aberrant expression of HLA Class II products on crypt enterocytes (3). More... »

PAGES

697-698

Book

TITLE

Advances in Mucosal Immunology

ISBN

978-94-010-7323-3
978-94-009-1848-1

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-94-009-1848-1_215

DOI

http://dx.doi.org/10.1007/978-94-009-1848-1_215

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1035953122


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