X-Linked Adrenoleukodystrophy: Identification of the Primary Defect at the Level of a Deficient Peroxisomal Very Long Chain Fatty Acyl-CoA Synthetase ... View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1988

AUTHORS

R. J. A. Wanders , C. W. T. van Roermund , M. J. A. van Wijland , R. B. H. Schutgens , A. W. Schram , J. M. Tager , H. van den Bosch , C. Schalkwijk

ABSTRACT

Several types of adrenoleukodystrophy (ALD) differing in age of onset, mode of inheritance and clinical presentation have been described in the literature. The X-linked form of adrenoleukodystrophy, which is the most common, is characterized by demyelination, adrenal sufficiency and the accumulation of very long chain fatty acids, particularly hexacosanoic acid (C26:0), in tissues and body fluids (Moser et al., 1984). It is now generally accepted that the accumulation of very long chain fatty acids in X-linked ALD is caused by their impaired degradation via the peroxisomal β-oxidation system as first shown by Singh and co-workers in 1981 (see also Rizzo et al., 1984; Singh et al., 1984; Tsuji et al., 1985). Recent studies have shown that the deficient peroxisomal oxidation of very long chain fatty acids in X- linked ALD is not caused by a deficiency of one of the peroxisomal β-oxidation enzymes (acyl-CoA oxidase, bifunctional protein with enoyl-CoA hydratase and 3-hydroxyacyl-CoA dehydrogenase activities and 3-oxoacyl-CoA thiolase) since all three enzyme proteins were not only found to be immunologically present as shown by immunoblotting (Wanders et al., 1987) but also functionally active (Hashmi et al., 1986; Wanders et al., 1987). The latter finding led Hashmi and co-workers to suggest that the defect in X-linked ALD is at the level of a deficient activation of very long chain fatty acids to their CoA-esters. However, measurement of this activity in X-linked ALD fibroblasts using tetracosanoic acid (C24:0) and hexacosanoic acid (C26:0) as substrates revealed only a partial (about 25%) very long chain acyl-CoA synthetase deficiency (Wanders et al., 1987a). More... »

PAGES

173-177

Book

TITLE

Studies in Inherited Metabolic Disease

ISBN

978-94-010-7059-1
978-94-009-1259-5

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-94-009-1259-5_24

DOI

http://dx.doi.org/10.1007/978-94-009-1259-5_24

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1004033382


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "VU University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.16872.3a", 
          "name": [
            "Department of Pediatrics, University Hospital Amsterdam, Meibergdreef 9, 1105 AZ\u00a0Amsterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wanders", 
        "givenName": "R. J. A.", 
        "id": "sg:person.012310667352.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012310667352.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "VU University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.16872.3a", 
          "name": [
            "Department of Pediatrics, University Hospital Amsterdam, Meibergdreef 9, 1105 AZ\u00a0Amsterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "van Roermund", 
        "givenName": "C. W. T.", 
        "id": "sg:person.01122105535.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122105535.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "VU University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.16872.3a", 
          "name": [
            "Department of Pediatrics, University Hospital Amsterdam, Meibergdreef 9, 1105 AZ\u00a0Amsterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "van Wijland", 
        "givenName": "M. J. A.", 
        "id": "sg:person.012337556274.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012337556274.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "VU University Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.16872.3a", 
          "name": [
            "Department of Pediatrics, University Hospital Amsterdam, Meibergdreef 9, 1105 AZ\u00a0Amsterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schutgens", 
        "givenName": "R. B. H.", 
        "id": "sg:person.015061171357.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015061171357.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Amsterdam", 
          "id": "https://www.grid.ac/institutes/grid.7177.6", 
          "name": [
            "Department of Biochemistry, University of Amsterdam, Meibergdreef 15, 1105 AZ\u00a0Amsterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schram", 
        "givenName": "A. W.", 
        "id": "sg:person.012436416414.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012436416414.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Amsterdam", 
          "id": "https://www.grid.ac/institutes/grid.7177.6", 
          "name": [
            "Department of Biochemistry, University of Amsterdam, Meibergdreef 15, 1105 AZ\u00a0Amsterdam, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tager", 
        "givenName": "J. M.", 
        "id": "sg:person.0627746335.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0627746335.85"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Utrecht University", 
          "id": "https://www.grid.ac/institutes/grid.5477.1", 
          "name": [
            "Laboratory of Biochemistry, State University Utrecht, Padualaan 8, 3584 CH\u00a0Utrecht, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "van den Bosch", 
        "givenName": "H.", 
        "id": "sg:person.01154226133.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01154226133.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Utrecht University", 
          "id": "https://www.grid.ac/institutes/grid.5477.1", 
          "name": [
            "Laboratory of Biochemistry, State University Utrecht, Padualaan 8, 3584 CH\u00a0Utrecht, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schalkwijk", 
        "givenName": "C.", 
        "id": "sg:person.0756704541.46", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756704541.46"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1002/ana.410160603", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005229613"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-510x(85)90074-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009802381"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-510x(85)90074-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009802381"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0009-8981(87)90177-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012806886"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0009-8981(87)90177-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012806886"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-291x(81)80142-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012896589"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0005-2760(87)90213-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017965532"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0005-2760(87)90213-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017965532"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-5793(86)80256-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030531152"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01811410", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032997173", 
          "https://doi.org/10.1007/bf01811410"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1007/bf01811410", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032997173"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.81.13.4203", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045398929"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.34.2.163", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064365229"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1988", 
    "datePublishedReg": "1988-01-01", 
    "description": "Several types of adrenoleukodystrophy (ALD) differing in age of onset, mode of inheritance and clinical presentation have been described in the literature. The X-linked form of adrenoleukodystrophy, which is the most common, is characterized by demyelination, adrenal sufficiency and the accumulation of very long chain fatty acids, particularly hexacosanoic acid (C26:0), in tissues and body fluids (Moser et al., 1984). It is now generally accepted that the accumulation of very long chain fatty acids in X-linked ALD is caused by their impaired degradation via the peroxisomal \u03b2-oxidation system as first shown by Singh and co-workers in 1981 (see also Rizzo et al., 1984; Singh et al., 1984; Tsuji et al., 1985). Recent studies have shown that the deficient peroxisomal oxidation of very long chain fatty acids in X- linked ALD is not caused by a deficiency of one of the peroxisomal \u03b2-oxidation enzymes (acyl-CoA oxidase, bifunctional protein with enoyl-CoA hydratase and 3-hydroxyacyl-CoA dehydrogenase activities and 3-oxoacyl-CoA thiolase) since all three enzyme proteins were not only found to be immunologically present as shown by immunoblotting (Wanders et al., 1987) but also functionally active (Hashmi et al., 1986; Wanders et al., 1987). The latter finding led Hashmi and co-workers to suggest that the defect in X-linked ALD is at the level of a deficient activation of very long chain fatty acids to their CoA-esters. However, measurement of this activity in X-linked ALD fibroblasts using tetracosanoic acid (C24:0) and hexacosanoic acid (C26:0) as substrates revealed only a partial (about 25%) very long chain acyl-CoA synthetase deficiency (Wanders et al., 1987a).", 
    "editor": [
      {
        "familyName": "Pollitt", 
        "givenName": "R. J.", 
        "type": "Person"
      }, 
      {
        "familyName": "Harkness", 
        "givenName": "R. A.", 
        "type": "Person"
      }, 
      {
        "familyName": "Addison", 
        "givenName": "G. M.", 
        "type": "Person"
      }
    ], 
    "genre": "chapter", 
    "id": "sg:pub.10.1007/978-94-009-1259-5_24", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": {
      "isbn": [
        "978-94-010-7059-1", 
        "978-94-009-1259-5"
      ], 
      "name": "Studies in Inherited Metabolic Disease", 
      "type": "Book"
    }, 
    "name": "X-Linked Adrenoleukodystrophy: Identification of the Primary Defect at the Level of a Deficient Peroxisomal Very Long Chain Fatty Acyl-CoA Synthetase Using a Newly Developed Method for the Isolation of Peroxisomes from Skin Fibroblasts", 
    "pagination": "173-177", 
    "productId": [
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/978-94-009-1259-5_24"
        ]
      }, 
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "1337b45a0261cbbad40ced8075467caa617a19f4eec7dca0ca4c0dfea2acd766"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1004033382"
        ]
      }
    ], 
    "publisher": {
      "location": "Dordrecht", 
      "name": "Springer Netherlands", 
      "type": "Organisation"
    }, 
    "sameAs": [
      "https://doi.org/10.1007/978-94-009-1259-5_24", 
      "https://app.dimensions.ai/details/publication/pub.1004033382"
    ], 
    "sdDataset": "chapters", 
    "sdDatePublished": "2019-04-15T10:30", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8659_00000245.jsonl", 
    "type": "Chapter", 
    "url": "http://link.springer.com/10.1007/978-94-009-1259-5_24"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-94-009-1259-5_24'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-94-009-1259-5_24'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-94-009-1259-5_24'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-94-009-1259-5_24'


 

This table displays all metadata directly associated to this object as RDF triples.

161 TRIPLES      23 PREDICATES      37 URIs      20 LITERALS      8 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/978-94-009-1259-5_24 schema:about anzsrc-for:06
2 anzsrc-for:0601
3 schema:author N82382aa1089341b0a0d794b6c66173c6
4 schema:citation sg:pub.10.1007/bf01811410
5 https://doi.org/10.1002/ana.410160603
6 https://doi.org/10.1007/bf01811410
7 https://doi.org/10.1016/0005-2760(87)90213-x
8 https://doi.org/10.1016/0009-8981(87)90177-x
9 https://doi.org/10.1016/0014-5793(86)80256-3
10 https://doi.org/10.1016/0022-510x(85)90074-7
11 https://doi.org/10.1016/s0006-291x(81)80142-8
12 https://doi.org/10.1073/pnas.81.13.4203
13 https://doi.org/10.1212/wnl.34.2.163
14 schema:datePublished 1988
15 schema:datePublishedReg 1988-01-01
16 schema:description Several types of adrenoleukodystrophy (ALD) differing in age of onset, mode of inheritance and clinical presentation have been described in the literature. The X-linked form of adrenoleukodystrophy, which is the most common, is characterized by demyelination, adrenal sufficiency and the accumulation of very long chain fatty acids, particularly hexacosanoic acid (C26:0), in tissues and body fluids (Moser et al., 1984). It is now generally accepted that the accumulation of very long chain fatty acids in X-linked ALD is caused by their impaired degradation via the peroxisomal β-oxidation system as first shown by Singh and co-workers in 1981 (see also Rizzo et al., 1984; Singh et al., 1984; Tsuji et al., 1985). Recent studies have shown that the deficient peroxisomal oxidation of very long chain fatty acids in X- linked ALD is not caused by a deficiency of one of the peroxisomal β-oxidation enzymes (acyl-CoA oxidase, bifunctional protein with enoyl-CoA hydratase and 3-hydroxyacyl-CoA dehydrogenase activities and 3-oxoacyl-CoA thiolase) since all three enzyme proteins were not only found to be immunologically present as shown by immunoblotting (Wanders et al., 1987) but also functionally active (Hashmi et al., 1986; Wanders et al., 1987). The latter finding led Hashmi and co-workers to suggest that the defect in X-linked ALD is at the level of a deficient activation of very long chain fatty acids to their CoA-esters. However, measurement of this activity in X-linked ALD fibroblasts using tetracosanoic acid (C24:0) and hexacosanoic acid (C26:0) as substrates revealed only a partial (about 25%) very long chain acyl-CoA synthetase deficiency (Wanders et al., 1987a).
17 schema:editor N7d13467ad94f4405a385d30a64097c76
18 schema:genre chapter
19 schema:inLanguage en
20 schema:isAccessibleForFree false
21 schema:isPartOf N1b17f994533c4afb9086348f0e3147b4
22 schema:name X-Linked Adrenoleukodystrophy: Identification of the Primary Defect at the Level of a Deficient Peroxisomal Very Long Chain Fatty Acyl-CoA Synthetase Using a Newly Developed Method for the Isolation of Peroxisomes from Skin Fibroblasts
23 schema:pagination 173-177
24 schema:productId N3918959a7788494785c0405eb391b9ad
25 N58ff2c4c46fc4d2dbecd447bf85d4ef4
26 N8278840faa8449b0b2ba729b81d1a07e
27 schema:publisher Nf2608227d0624bf592372d69b95f2ec9
28 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004033382
29 https://doi.org/10.1007/978-94-009-1259-5_24
30 schema:sdDatePublished 2019-04-15T10:30
31 schema:sdLicense https://scigraph.springernature.com/explorer/license/
32 schema:sdPublisher N168eb03be74c4ee4ad6f89963fcf2f4f
33 schema:url http://link.springer.com/10.1007/978-94-009-1259-5_24
34 sgo:license sg:explorer/license/
35 sgo:sdDataset chapters
36 rdf:type schema:Chapter
37 N0484b213538f4cbb8101a6a99e5f99c5 schema:familyName Harkness
38 schema:givenName R. A.
39 rdf:type schema:Person
40 N0edf9d5ba4414e00a02b2750e2799fff rdf:first sg:person.012436416414.28
41 rdf:rest N24fc4f3b0a8d486383d00a3716e5c697
42 N168eb03be74c4ee4ad6f89963fcf2f4f schema:name Springer Nature - SN SciGraph project
43 rdf:type schema:Organization
44 N1b17f994533c4afb9086348f0e3147b4 schema:isbn 978-94-009-1259-5
45 978-94-010-7059-1
46 schema:name Studies in Inherited Metabolic Disease
47 rdf:type schema:Book
48 N24fc4f3b0a8d486383d00a3716e5c697 rdf:first sg:person.0627746335.85
49 rdf:rest N7ba70424b94d44c39c83ba563f35c9c6
50 N375f61e518f5416e97e222dbab95ef2e rdf:first sg:person.0756704541.46
51 rdf:rest rdf:nil
52 N37e85cbbeb794fd4b710795c824ee548 schema:familyName Pollitt
53 schema:givenName R. J.
54 rdf:type schema:Person
55 N3918959a7788494785c0405eb391b9ad schema:name readcube_id
56 schema:value 1337b45a0261cbbad40ced8075467caa617a19f4eec7dca0ca4c0dfea2acd766
57 rdf:type schema:PropertyValue
58 N58ff2c4c46fc4d2dbecd447bf85d4ef4 schema:name doi
59 schema:value 10.1007/978-94-009-1259-5_24
60 rdf:type schema:PropertyValue
61 N7873e13a2e3a4784a13fdd40ec158dcf rdf:first sg:person.012337556274.11
62 rdf:rest N886087f6d0ad4c57ac42e9de67287fc2
63 N7ba70424b94d44c39c83ba563f35c9c6 rdf:first sg:person.01154226133.81
64 rdf:rest N375f61e518f5416e97e222dbab95ef2e
65 N7d13467ad94f4405a385d30a64097c76 rdf:first N37e85cbbeb794fd4b710795c824ee548
66 rdf:rest Nd25b90ee48ee40b580dee4cf3e3c0321
67 N82382aa1089341b0a0d794b6c66173c6 rdf:first sg:person.012310667352.11
68 rdf:rest Ne54ee5590726483397b3f7dd25680609
69 N8278840faa8449b0b2ba729b81d1a07e schema:name dimensions_id
70 schema:value pub.1004033382
71 rdf:type schema:PropertyValue
72 N886087f6d0ad4c57ac42e9de67287fc2 rdf:first sg:person.015061171357.54
73 rdf:rest N0edf9d5ba4414e00a02b2750e2799fff
74 N9f7bc172fe92479da39263e17c0f1758 rdf:first Nac13372e46d8424f81bd861a1869c85a
75 rdf:rest rdf:nil
76 Nac13372e46d8424f81bd861a1869c85a schema:familyName Addison
77 schema:givenName G. M.
78 rdf:type schema:Person
79 Nd25b90ee48ee40b580dee4cf3e3c0321 rdf:first N0484b213538f4cbb8101a6a99e5f99c5
80 rdf:rest N9f7bc172fe92479da39263e17c0f1758
81 Ne54ee5590726483397b3f7dd25680609 rdf:first sg:person.01122105535.00
82 rdf:rest N7873e13a2e3a4784a13fdd40ec158dcf
83 Nf2608227d0624bf592372d69b95f2ec9 schema:location Dordrecht
84 schema:name Springer Netherlands
85 rdf:type schema:Organisation
86 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
87 schema:name Biological Sciences
88 rdf:type schema:DefinedTerm
89 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
90 schema:name Biochemistry and Cell Biology
91 rdf:type schema:DefinedTerm
92 sg:person.01122105535.00 schema:affiliation https://www.grid.ac/institutes/grid.16872.3a
93 schema:familyName van Roermund
94 schema:givenName C. W. T.
95 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01122105535.00
96 rdf:type schema:Person
97 sg:person.01154226133.81 schema:affiliation https://www.grid.ac/institutes/grid.5477.1
98 schema:familyName van den Bosch
99 schema:givenName H.
100 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01154226133.81
101 rdf:type schema:Person
102 sg:person.012310667352.11 schema:affiliation https://www.grid.ac/institutes/grid.16872.3a
103 schema:familyName Wanders
104 schema:givenName R. J. A.
105 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012310667352.11
106 rdf:type schema:Person
107 sg:person.012337556274.11 schema:affiliation https://www.grid.ac/institutes/grid.16872.3a
108 schema:familyName van Wijland
109 schema:givenName M. J. A.
110 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012337556274.11
111 rdf:type schema:Person
112 sg:person.012436416414.28 schema:affiliation https://www.grid.ac/institutes/grid.7177.6
113 schema:familyName Schram
114 schema:givenName A. W.
115 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012436416414.28
116 rdf:type schema:Person
117 sg:person.015061171357.54 schema:affiliation https://www.grid.ac/institutes/grid.16872.3a
118 schema:familyName Schutgens
119 schema:givenName R. B. H.
120 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015061171357.54
121 rdf:type schema:Person
122 sg:person.0627746335.85 schema:affiliation https://www.grid.ac/institutes/grid.7177.6
123 schema:familyName Tager
124 schema:givenName J. M.
125 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0627746335.85
126 rdf:type schema:Person
127 sg:person.0756704541.46 schema:affiliation https://www.grid.ac/institutes/grid.5477.1
128 schema:familyName Schalkwijk
129 schema:givenName C.
130 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756704541.46
131 rdf:type schema:Person
132 sg:pub.10.1007/bf01811410 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032997173
133 https://doi.org/10.1007/bf01811410
134 rdf:type schema:CreativeWork
135 https://doi.org/10.1002/ana.410160603 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005229613
136 rdf:type schema:CreativeWork
137 https://doi.org/10.1007/bf01811410 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032997173
138 rdf:type schema:CreativeWork
139 https://doi.org/10.1016/0005-2760(87)90213-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1017965532
140 rdf:type schema:CreativeWork
141 https://doi.org/10.1016/0009-8981(87)90177-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1012806886
142 rdf:type schema:CreativeWork
143 https://doi.org/10.1016/0014-5793(86)80256-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030531152
144 rdf:type schema:CreativeWork
145 https://doi.org/10.1016/0022-510x(85)90074-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009802381
146 rdf:type schema:CreativeWork
147 https://doi.org/10.1016/s0006-291x(81)80142-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012896589
148 rdf:type schema:CreativeWork
149 https://doi.org/10.1073/pnas.81.13.4203 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045398929
150 rdf:type schema:CreativeWork
151 https://doi.org/10.1212/wnl.34.2.163 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064365229
152 rdf:type schema:CreativeWork
153 https://www.grid.ac/institutes/grid.16872.3a schema:alternateName VU University Medical Center
154 schema:name Department of Pediatrics, University Hospital Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands
155 rdf:type schema:Organization
156 https://www.grid.ac/institutes/grid.5477.1 schema:alternateName Utrecht University
157 schema:name Laboratory of Biochemistry, State University Utrecht, Padualaan 8, 3584 CH Utrecht, The Netherlands
158 rdf:type schema:Organization
159 https://www.grid.ac/institutes/grid.7177.6 schema:alternateName University of Amsterdam
160 schema:name Department of Biochemistry, University of Amsterdam, Meibergdreef 15, 1105 AZ Amsterdam, The Netherlands
161 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...