Nitric Oxide Regulating Proteins as Biochemical and Genetic Markers of Coronary Artery Disease View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2015

AUTHORS

Mohamed Z. Gad , Sahar M. Abdel-Maksoud , Sally I. Hassanein , Ingy M. Hashad , Mohamed F. Abdel Rahman , Mohamed A. Abu el Maaty , Gamal M. Shaban , Khaled Abou-Aisha

ABSTRACT

Cardiovascular disease (CVD) remains the leading cause of death worldwide. Despite huge efforts and great advances in studying the genetic component of CVD, there is still a great need for exploring the genetic and environmental factors contributing to the development of this disease. Among these factors evolve modulation of nitric oxide (NO) homeostasis and oxidative stress as central players according to recent reports. A wide range of biochemical disturbances, including reduced bioavailability of NO and oxidative stress, has been shown to be associated with endothelial dysfunction (ED). Many studies described the contribution of ED in the predisposition of CVD, particularly coronary artery disease (CAD). Recent evidence indicates that ED may be genetically determined. This chapter points out to the key players that influence vascular NO levels and their role in the protection against and/or predisposition to CAD. More... »

PAGES

1-27

Book

TITLE

Biomarkers in Cardiovascular Disease

ISBN

978-94-007-7741-5

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-94-007-7741-5_34-1

DOI

http://dx.doi.org/10.1007/978-94-007-7741-5_34-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1051686702


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