HER2 as Biomarker for Endometrial Cancer Epidermal growth factor receptor-2 HER2 View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2015

AUTHORS

Diana P. English , Dana Marie Roque , Natalia Buza , Alessandro D. Santin

ABSTRACT

HER2 or ErbB2 is a member of the epidermal growth factor family and is a well-established biomarker that is overexpressed in a wide variety of tumor types including breast, ovarian, gastric, colorectal, pancreatic, and endometrial cancers. HER2 regulates signaling through several pathways (Ras/Raf/mitogen-activated protein kinase and phosphatidylinositol-3 kinase/protein kinase-B/mammalian target of rapamycin pathways) associated with cell survival and proliferation. In endometrial cancer there have been several studies linking the overexpression of HER2 and/or the amplification of the c-erbB2 gene with chemoresistance and overall poor survival. Immunotherapy with monoclonal antibodies targeting HER2 as well as the use of novel tyrosine kinase inhibitors targeting the erbB pathway may hold promise for patients harboring these biologically aggressive endometrial neoplasms. More... »

PAGES

507-526

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  • Book

    TITLE

    Biomarkers in Cancer

    ISBN

    978-94-007-7680-7
    978-94-007-7681-4

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/978-94-007-7681-4_26

    DOI

    http://dx.doi.org/10.1007/978-94-007-7681-4_26

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1020855955


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