Ontology type: schema:Chapter
2014
AUTHORSC. Roy , C. L. Addison , S. Mazzarello , I. Kuchuk , B. Hutton , M. Clemons
ABSTRACTBone metastases from advanced stage cancers are common. They pose a significant added burden on both the patient and the health care system as a whole. There has been extensive interest in developing new strategies to improve patient care in this area. Traditionally, trials have focused on the incidence and timing of skeletal-related events (SREs) to compare the efficacy of bone–targeted agents against placebo and against each other. However, there are fundamental issues with translating clinical trial data into widespread clinical care. As seen in clinical trials that tend to include patients with better performance status, enroll fewer patients with bone only disease, and use more bone imaging than is used in the real world setting. Therefore, we need more practical tools that will allow us to assess therapeutic response in the clinical setting. In reality, this will prove challenging, as so far we have been unable to combine commonly used clinical trial endpoints with endpoints that are pertinent to an individual patient in a pragmatic and validated manner. This chapter will review the common clinical outcome measures used to assess response and progression in patients with bone metastases. More... »
PAGES407-417
Bone Metastases
ISBN
978-94-007-7568-8
978-94-007-7569-5
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DOIhttp://dx.doi.org/10.1007/978-94-007-7569-5_22
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