The Wnt/β-Catenin Pathway as a Potential Target for Drug Resistant Leukemic Stem Cells View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2013-02-26

AUTHORS

Tsz Kan Fung , Anskar Y. H. Leung , Chi Wai Eric So

ABSTRACT

Components of the canonical Wnt/β-catenin signaling pathway are frequently mutated in cancer, and their deregulation has also been recently associated with the development of cancer stem cells (CSCs). Elevation of β-catenin activity is critical for blast transformation and drug resistant property of the stem cells in both chronic and acute myeloid leukemia, although the underlying mechanisms are still largely unknown. In this chapter, we will focus on the role of Wnt/β-catenin pathway in normal hematopoietic and leukemic stem cells. We will also review currently available small molecule inhibitors that target the canonical Wnt signaling, and propose their potential applications in combination with chemotherapy for cancer treatment. More... »

PAGES

163-172

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-94-007-6262-6_14

DOI

http://dx.doi.org/10.1007/978-94-007-6262-6_14

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1025508634


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