Role of Senescence Induction in Cancer Therapy View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2013

AUTHORS

Hiroshi Kondoh , Takumi Mikawa , Matilde E. LLeonart

ABSTRACT

Cellular immortalization is a crucial and early step during the development of cancer, while normal primary mammalian cells reach replicative limitation after several passages in vitro, called replicative senescence. Senescent cells have altered cell morphology and gene expression patterns with preserved metabolic activity, which are quite distinct from others. Interestingly, senescent cells have also been detected in vivo, particularly in benign lesions of human tumors. Senescence would constitute a protective barrier against cancerous immortalization. In other words, during tumorigenesis, cancer cells acquire genetic alterations to override senescence. By using high throughput genetic screening to search for genes involved in senescence, several candidates for oncogenes and putative tumor suppressor genes have been recently isolated, including subtypes of micro-RNAs. These findings offer new perspectives in the senescence biology and open new avenues for cancer therapy. More... »

PAGES

281-289

Book

TITLE

Tumor Dormancy, Quiescence, and Senescence, Volume 1

ISBN

978-94-007-5957-2
978-94-007-5958-9

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-94-007-5958-9_24

DOI

http://dx.doi.org/10.1007/978-94-007-5958-9_24

DIMENSIONS

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