Production of Fumaric Acid by Fermentation View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2012

AUTHORS

Adrie J. J. Straathof , Walter M. van Gulik

ABSTRACT

Fermentative fumaric acid production from renewable resources may become competitive with petrochemical production. This will require very efficient processes. So far, using Rhizopus strains, the best fermentations reported have achieved a fumaric acid titer of 126 g/L with a productivity of 1.38 g L(-1) h(-1) and a yield on glucose of 0.97 g/g. This requires pH control, aeration, and carbonate/CO(2) supply. Limitations of the used strains are their pH tolerance, morphology, accessibility for genetic engineering, and partly, versatility to alternative carbon sources. Understanding of the mechanism and energetics of fumaric acid export by Rhizopus strains will be a success factor for metabolic engineering of other hosts for fumaric acid production. So far, metabolic engineering has been described for Escherichia coli and Saccharomyces cerevisiae. More... »

PAGES

225-240

References to SciGraph publications

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/978-94-007-5055-5_11

    DOI

    http://dx.doi.org/10.1007/978-94-007-5055-5_11

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1040637613

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/23080253


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