Engineered Meganucleases for Genome Engineering Purposes View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2013

AUTHORS

Jean Charles Epinat , George H. Silva , Frédéric Pâques , Julianne Smith , Philippe Duchateau

ABSTRACT

Over the past 15 years, site-directed genome modification has proven to be an efficient and robust approach. Meganucleases, sequence-specific endonucleases with long recognition sites, represent one of several tools described in this book that can be used for this purpose. This chapter will review the early stages of the technology (with the first strand break-induced gene targeting with I-SceI), and describe the recent advances in protein engineering that have led to the making of tailored meganucleases. We will then summarize the data and strategies available today regarding their use for site-directed genome modification. In the last section, we will discuss the latest data available on Transcription activator like effectors proteins as they have recently emerged as a promising new tool for genome modifications. More... »

PAGES

147-185

References to SciGraph publications

  • 1990-08. Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in midbrain and cerebellar development in NATURE
  • 2005-11. Multiple large segment deletion method for Corynebacterium glutamicum in APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
  • 2011-05-12. A synthetic homing endonuclease-based gene drive system in the human malaria mosquito in NATURE
  • 2009-08. Targeted mutagenesis in the progeny of maize transgenic plants in PLANT MOLECULAR BIOLOGY
  • 2002-01. Gene replacement by homologous recombination in plants in PLANT MOLECULAR BIOLOGY
  • 2008-11. Molecular basis of xeroderma pigmentosum group C DNA recognition by engineered meganucleases in NATURE
  • 2009-10. Exploitation of binding energy for catalysis and design in NATURE
  • 1997-06. The structure of I-Crel, a Group I intron-encoded homing endonuclease in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 1990-11. Targeted insertion of the neomycin phosphotransferase gene into the tubulin gene cluster of Trypanosoma brucei in NATURE
  • 1999. Use of I-Sce I to Induce DNA Double-Strand Breaks in Nicotiana in DNA REPAIR PROTOCOLS
  • 2011-08. Targeted gene disruption in somatic zebrafish cells using engineered TALENs in NATURE BIOTECHNOLOGY
  • 2011-08. Heritable gene targeting in zebrafish using customized TALENs in NATURE BIOTECHNOLOGY
  • 2002-10. Crystal structure of the intein homing endonuclease PI-SceI bound to its recognition sequence in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2001-04-01. The homing endonuclease I-CreI uses three metals, one of which is shared between the two active sites in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2009-09. Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases in NATURE BIOTECHNOLOGY
  • 1987-12. Targetted correction of a mutant HPRT gene in mouse embryonic stem cells in NATURE
  • 2011-02. Efficient construction of sequence-specific TAL effectors for modulating mammalian transcription in NATURE BIOTECHNOLOGY
  • 2007-07. Structure-based redesign of the dimerization interface reduces the toxicity of zinc-finger nucleases in NATURE BIOTECHNOLOGY
  • 1985-05. Selfish DNA and the origin of introns in NATURE
  • 2008. Triplex-Mediated Gene Modification in CHROMOSOMAL MUTAGENESIS
  • 2006-11. High-throughput transgenesis in Xenopus using I-SceI meganuclease in NATURE PROTOCOLS
  • 2008. Recent Advances in Meganuclease-and Transposon-Mediated Transgenesis of Medaka and Zebrafish in MOLECULAR EMBRYOLOGY
  • 2008-06. Targeted gene inactivation in zebrafish using engineered zinc-finger nucleases in NATURE BIOTECHNOLOGY
  • 1999-02-01. A similar active site for non–specific and specific endonucleases in NATURE STRUCTURAL & MOLECULAR BIOLOGY
  • 2008. Robust Cell Line Development Using Meganucleases in CHROMOSOMAL MUTAGENESIS
  • 2007-11. Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery in NATURE BIOTECHNOLOGY
  • 2008-06. Heritable targeted gene disruption in zebrafish using designed zinc-finger nucleases in NATURE BIOTECHNOLOGY
  • 2011-02. A TALE nuclease architecture for efficient genome editing in NATURE BIOTECHNOLOGY
  • 2011-08. Knockout rats generated by embryo microinjection of TALENs in NATURE BIOTECHNOLOGY
  • 2010-03. Homing endonucleases: from basics to therapeutic applications in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 2009. Generation of Transgenic Frogs in TRANSGENESIS TECHNIQUES
  • 2005-06. Highly efficient endogenous human gene correction using designed zinc-finger nucleases in NATURE
  • 2001-10. Generating mice with targeted mutations in NATURE MEDICINE
  • 2007-12. Scarless and site-directed mutagenesis in Salmonella enteritidischromosome in BMC BIOTECHNOLOGY
  • 1989-07. Genetic and structural characterization of the avirulence gene avrBs3 from Xanthomonas campestris pv. vesicatoria in MOLECULAR GENETICS AND GENOMICS
  • 2001-10. Forty years with homologous recombination in NATURE MEDICINE
  • 1988-11. Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes in NATURE
  • 2006-06. Computational redesign of endonuclease DNA binding and cleavage specificity in NATURE
  • 1998-07. DNA binding and cleavage by the nuclear intron-encoded homing endonuclease I-PpoI in NATURE
  • 2009-05. High-frequency modification of plant genes using engineered zinc-finger nucleases in NATURE
  • 2011-08. Genetic engineering of human pluripotent cells using TALE nucleases in NATURE BIOTECHNOLOGY
  • 2011-01. Developing transgenic Anopheles mosquitoes for the sterile insect technique in GENETICA
  • 2008. Methods for Homologous Recombination in Drosophila in DROSOPHILA
  • Book

    TITLE

    Site-directed insertion of transgenes

    ISBN

    978-94-007-4530-8
    978-94-007-4531-5

    Author Affiliations

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/978-94-007-4531-5_6

    DOI

    http://dx.doi.org/10.1007/978-94-007-4531-5_6

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1028090798


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