Engineered Zinc Finger Nucleases for Targeted Genome Editing View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2013

AUTHORS

Cherie L. Ramirez , J. Keith Joung

ABSTRACT

Zinc finger nucleases (ZFNs) are artificial proteins consisting of engineered zinc finger proteins fused to the FokI endonuclease domain. These nucleases bind to specific DNA recognition sites and introduce double-strand breaks (DSBs). Repair of these DSBs by normal cellular processes can be exploited to either disrupt genes or significantly increase the frequency of homologous recombination with a user-defined repair template. Several platforms have been developed that enable engineering of zinc finger proteins that bind with high affinity and specificity to 9–18 bp target DNA sequences. ZFNs have already been used in basic research, most prominently with the development of methods to efficiently modify various model organisms and cell lines. More... »

PAGES

121-145

References to SciGraph publications

  • 2011-10. Site-specific integration and tailoring of cassette design for sustainable gene transfer in NATURE METHODS
  • 2008-06. Targeted gene inactivation in zebrafish using engineered zinc-finger nucleases in NATURE BIOTECHNOLOGY
  • 2011-09. Revealing off-target cleavage specificities of zinc-finger nucleases by in vitro selection in NATURE METHODS
  • 2006-08. Standardized reagents and protocols for engineering zinc finger nucleases by modular assembly in NATURE PROTOCOLS
  • 2001-03. Chromosomal stability and the DNA double-stranded break connection in NATURE REVIEWS GENETICS
  • 2011-09. High-frequency genome editing using ssDNA oligonucleotides with zinc-finger nucleases in NATURE METHODS
  • 2010-06. Transient cold shock enhances zinc-finger nuclease–mediated gene disruption in NATURE METHODS
  • 2008-07. Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases in NATURE BIOTECHNOLOGY
  • 2010-06-25. The Generation of Zinc Finger Proteins by Modular Assembly in ENGINEERED ZINC FINGER PROTEINS
  • 2010. Modulation of Gene Expression Using Zinc Finger-Based Artificial Transcription Factors in ENGINEERED ZINC FINGER PROTEINS
  • 2001-07. A rapid, generally applicable method to engineer zinc fingers illustrated by targeting the HIV-1 promoter in NATURE BIOTECHNOLOGY
  • 1994-12. In vivo repression by a site-specific DNA-binding protein designed against an oncogenic sequence in NATURE
  • 2010-12. Analysis of illegitimate genomic integration mediated by zinc-finger nucleases: implications for specificity of targeted gene correction in BMC MOLECULAR BIOLOGY
  • 2002-03. Target integration by a chimeric Sp1 zinc finger domain-moloney murine leukemia virus integrase in vivo in JOURNAL OF BIOMEDICAL SCIENCE
  • 2008-05. Unexpected failure rates for modular assembly of engineered zinc fingers in NATURE METHODS
  • 2001-02. Expressing the human genome in NATURE
  • 2010-02. Construction and testing of engineered zinc-finger proteins for sequence-specific modification of mtDNA in NATURE PROTOCOLS
  • 2011-01. Targeted integration in rat and mouse embryos with zinc-finger nucleases in NATURE BIOTECHNOLOGY
  • 2009-09. Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases in NATURE BIOTECHNOLOGY
  • 2010-12. Predicting success of oligomerized pool engineering (OPEN) for zinc finger target site sequences in BMC BIOINFORMATICS
  • 2011-12. ZFN-Site searches genomes for zinc finger nuclease target sites and off-target sites in BMC BIOINFORMATICS
  • 2011-06-26. In vivo genome editing restores haemostasis in a mouse model of haemophilia in NATURE
  • 2011-01. Enhancing zinc-finger-nuclease activity with improved obligate heterodimeric architectures in NATURE METHODS
  • 2007-07. Structure-based redesign of the dimerization interface reduces the toxicity of zinc-finger nucleases in NATURE BIOTECHNOLOGY
  • 2009-05. High-frequency modification of plant genes using engineered zinc-finger nucleases in NATURE
  • 2007-07. An improved zinc-finger nuclease architecture for highly specific genome editing in NATURE BIOTECHNOLOGY
  • 2003-05. Drug discovery with engineered zinc-finger proteins in NATURE REVIEWS DRUG DISCOVERY
  • 2008-05. The Protein-Binding Potential of C2H2 Zinc Finger Domains in CELL BIOCHEMISTRY AND BIOPHYSICS
  • 2003-03. Targeted regulation of imprinted genes by synthetic zinc-finger transcription factors in GENE THERAPY
  • 2010-06-25. A Rapid and General Assay for Monitoring Endogenous Gene Modification in ENGINEERED ZINC FINGER PROTEINS
  • 2010-06-25. Engineered Zinc Finger Proteins for Manipulation of the Human Mitochondrial Genome in ENGINEERED ZINC FINGER PROTEINS
  • 2007-11. Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery in NATURE BIOTECHNOLOGY
  • 2008-06. Heritable targeted gene disruption in zebrafish using designed zinc-finger nucleases in NATURE BIOTECHNOLOGY
  • 2008-09-11. Protein engineering: The fate of fingers in NATURE
  • 2011-12. An update on targeted gene repair in mammalian cells: methods and mechanisms in JOURNAL OF BIOMEDICAL SCIENCE
  • 2010-03. Double knockouts in human embryonic stem cells in CELL RESEARCH
  • 2002-12. Induction of angiogenesis in a mouse model using engineered transcription factors in NATURE MEDICINE
  • 2010-02. Genome editing with modularly assembled zinc-finger nucleases in NATURE METHODS
  • 2010-02. Reply to “Genome editing with modularly assembled zinc-finger nucleases” in NATURE METHODS
  • 2011-09. An unbiased genome-wide analysis of zinc-finger nuclease specificity in NATURE BIOTECHNOLOGY
  • 2009-10. Oligomerized pool engineering (OPEN): an 'open-source' protocol for making customized zinc-finger arrays in NATURE PROTOCOLS
  • 2011-03. Rapid and efficient clathrin-mediated endocytosis revealed in genome-edited mammalian cells in NATURE CELL BIOLOGY
  • 2009-10-28. Generation of Gene-Specific Mutated Rats Using Zinc-Finger Nucleases in RAT GENOMICS
  • 2005-06. Highly efficient endogenous human gene correction using designed zinc-finger nucleases in NATURE
  • 2011-12. ZFNGenome: A comprehensive resource for locating zinc finger nuclease target sites in model organisms in BMC GENOMICS
  • 2003-03. Human zinc fingers as building blocks in the construction of artificial transcription factors in NATURE BIOTECHNOLOGY
  • 2011-06. Generation of PPARγ mono-allelic knockout pigs via zinc-finger nucleases and nuclear transfer cloning in CELL RESEARCH
  • 2010-01. Zinc positive: tailored genome engineering meets reprogramming in GENE THERAPY
  • 2011-01. Selection-free zinc-finger-nuclease engineering by context-dependent assembly (CoDA) in NATURE METHODS
  • 2009-05. Precise genome modification in the crop species Zea mays using zinc-finger nucleases in NATURE
  • 2005-03. Type II restriction endonucleases: structure and mechanism in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 2009-12. Targeted mutagenesis in zebrafish using customized zinc-finger nucleases in NATURE PROTOCOLS
  • 2010-08. Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo in NATURE BIOTECHNOLOGY
  • Book

    TITLE

    Site-directed insertion of transgenes

    ISBN

    978-94-007-4530-8
    978-94-007-4531-5

    Author Affiliations

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/978-94-007-4531-5_5

    DOI

    http://dx.doi.org/10.1007/978-94-007-4531-5_5

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1027512856


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