Bio-applications Derived from Site-Directed Genome Modification Technologies View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2013

AUTHORS

Christophe Delenda , Sébastien Paris , Sylvain Arnould , Edward Balbirnie , Jean-Pierre Cabaniols

ABSTRACT

This review summarizes the overall downstream applications of currently available genome customization systems, based on cell-based assays (in cellulo) or animal models (in vivo). These include (i) functional genomics, (ii) drug discovery, (iii) bioproduction, (iv) cell transformation (i.e. immortalization, reprogrammation and differentiation), as well as (v) molecular biology and microbiology tools. The different enzymatic systems that exist to specifically modify (insertional or site-directed mutagenesis), modulate (knock-down) and disrupt (constitutive or conditional knock-out) cellular genes, or to integrate transgenic elements (knock-in) at specific chromosomal loci will be discussed herein. More... »

PAGES

353-384

References to SciGraph publications

  • 2006. Oligonucleotides in ENCYCLOPEDIC REFERENCE OF GENOMICS AND PROTEOMICS IN MOLECULAR MEDICINE
  • Book

    TITLE

    Site-directed insertion of transgenes

    ISBN

    978-94-007-4530-8
    978-94-007-4531-5

    Author Affiliations

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/978-94-007-4531-5_14

    DOI

    http://dx.doi.org/10.1007/978-94-007-4531-5_14

    DIMENSIONS

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