Bio-applications Derived from Site-Directed Genome Modification Technologies View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2013

AUTHORS

Christophe Delenda , Sébastien Paris , Sylvain Arnould , Edward Balbirnie , Jean-Pierre Cabaniols

ABSTRACT

This review summarizes the overall downstream applications of currently available genome customization systems, based on cell-based assays (in cellulo) or animal models (in vivo). These include (i) functional genomics, (ii) drug discovery, (iii) bioproduction, (iv) cell transformation (i.e. immortalization, reprogrammation and differentiation), as well as (v) molecular biology and microbiology tools. The different enzymatic systems that exist to specifically modify (insertional or site-directed mutagenesis), modulate (knock-down) and disrupt (constitutive or conditional knock-out) cellular genes, or to integrate transgenic elements (knock-in) at specific chromosomal loci will be discussed herein. More... »

PAGES

353-384

References to SciGraph publications

  • 2006. Oligonucleotides in ENCYCLOPEDIC REFERENCE OF GENOMICS AND PROTEOMICS IN MOLECULAR MEDICINE
  • Book

    TITLE

    Site-directed insertion of transgenes

    ISBN

    978-94-007-4530-8
    978-94-007-4531-5

    Author Affiliations

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/978-94-007-4531-5_14

    DOI

    http://dx.doi.org/10.1007/978-94-007-4531-5_14

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1032281943


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Genetics", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "name": [
                "Cellectis Bioresearch, Biopark, 8 rue de la Croix de Jarry, 75013\u00a0Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Delenda", 
            "givenName": "Christophe", 
            "id": "sg:person.015375772004.39", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015375772004.39"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Cellectis Bioresearch, Biopark, 8 rue de la Croix de Jarry, 75013\u00a0Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Paris", 
            "givenName": "S\u00e9bastien", 
            "id": "sg:person.01146646440.35", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146646440.35"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Cellectis Therapeutics, Biopark, 8 rue de la Croix de Jarry, 75013\u00a0Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Arnould", 
            "givenName": "Sylvain", 
            "id": "sg:person.01343176221.23", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01343176221.23"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Genopole (France)", 
              "id": "https://www.grid.ac/institutes/grid.434726.0", 
              "name": [
                "Ectycell, 5 rue Henri Desru\u00e8res, Genopole, 91030\u00a0Evry, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Balbirnie", 
            "givenName": "Edward", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Cellectis Bioresearch, Biopark, 8 rue de la Croix de Jarry, 75013\u00a0Paris, France"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cabaniols", 
            "givenName": "Jean-Pierre", 
            "id": "sg:person.01074351560.43", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074351560.43"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1534/genetics.111.127506", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007160574"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1534/genetics.111.127506", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007160574"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/gkr188", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030793292"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/3-540-29623-9_8075", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042834910", 
              "https://doi.org/10.1007/3-540-29623-9_8075"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3791/2010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071422439"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2013", 
        "datePublishedReg": "2013-01-01", 
        "description": "This review summarizes the overall downstream applications of currently available genome customization systems, based on cell-based assays (in cellulo) or animal models (in vivo). These include (i) functional genomics, (ii) drug discovery, (iii) bioproduction, (iv) cell transformation (i.e. immortalization, reprogrammation and differentiation), as well as (v) molecular biology and microbiology tools. The different enzymatic systems that exist to specifically modify (insertional or site-directed mutagenesis), modulate (knock-down) and disrupt (constitutive or conditional knock-out) cellular genes, or to integrate transgenic elements (knock-in) at specific chromosomal loci will be discussed herein.", 
        "editor": [
          {
            "familyName": "Renault", 
            "givenName": "Sylvaine", 
            "type": "Person"
          }, 
          {
            "familyName": "Duchateau", 
            "givenName": "Philippe", 
            "type": "Person"
          }
        ], 
        "genre": "chapter", 
        "id": "sg:pub.10.1007/978-94-007-4531-5_14", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isPartOf": {
          "isbn": [
            "978-94-007-4530-8", 
            "978-94-007-4531-5"
          ], 
          "name": "Site-directed insertion of transgenes", 
          "type": "Book"
        }, 
        "name": "Bio-applications Derived from Site-Directed Genome Modification Technologies", 
        "pagination": "353-384", 
        "productId": [
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/978-94-007-4531-5_14"
            ]
          }, 
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "99c8ffee567f73ab10e446e47e220a761394a9e417fce3062f31f75e524c5cc1"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1032281943"
            ]
          }
        ], 
        "publisher": {
          "location": "Dordrecht", 
          "name": "Springer Netherlands", 
          "type": "Organisation"
        }, 
        "sameAs": [
          "https://doi.org/10.1007/978-94-007-4531-5_14", 
          "https://app.dimensions.ai/details/publication/pub.1032281943"
        ], 
        "sdDataset": "chapters", 
        "sdDatePublished": "2019-04-15T11:35", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8660_00000263.jsonl", 
        "type": "Chapter", 
        "url": "http://link.springer.com/10.1007/978-94-007-4531-5_14"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-94-007-4531-5_14'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-94-007-4531-5_14'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-94-007-4531-5_14'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-94-007-4531-5_14'


     

    This table displays all metadata directly associated to this object as RDF triples.

    118 TRIPLES      23 PREDICATES      31 URIs      20 LITERALS      8 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/978-94-007-4531-5_14 schema:about anzsrc-for:06
    2 anzsrc-for:0604
    3 schema:author N01369ba5ecc1432493e216f281842445
    4 schema:citation sg:pub.10.1007/3-540-29623-9_8075
    5 https://doi.org/10.1093/nar/gkr188
    6 https://doi.org/10.1534/genetics.111.127506
    7 https://doi.org/10.3791/2010
    8 schema:datePublished 2013
    9 schema:datePublishedReg 2013-01-01
    10 schema:description This review summarizes the overall downstream applications of currently available genome customization systems, based on cell-based assays (in cellulo) or animal models (in vivo). These include (i) functional genomics, (ii) drug discovery, (iii) bioproduction, (iv) cell transformation (i.e. immortalization, reprogrammation and differentiation), as well as (v) molecular biology and microbiology tools. The different enzymatic systems that exist to specifically modify (insertional or site-directed mutagenesis), modulate (knock-down) and disrupt (constitutive or conditional knock-out) cellular genes, or to integrate transgenic elements (knock-in) at specific chromosomal loci will be discussed herein.
    11 schema:editor N6902de3720bd4e058548610e7b8610ac
    12 schema:genre chapter
    13 schema:inLanguage en
    14 schema:isAccessibleForFree false
    15 schema:isPartOf Ne809fa4f7b7540a690d95bf7fbc5b48d
    16 schema:name Bio-applications Derived from Site-Directed Genome Modification Technologies
    17 schema:pagination 353-384
    18 schema:productId N26b6016673764888bd3e625ebe73aa62
    19 N4aa70ca633c54fc788bb412c9b2bf4d1
    20 N60077e82e6f641b6b2dc7d3f5647d955
    21 schema:publisher Na23c69fc056443fd99afc25f63f1fb8c
    22 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032281943
    23 https://doi.org/10.1007/978-94-007-4531-5_14
    24 schema:sdDatePublished 2019-04-15T11:35
    25 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    26 schema:sdPublisher Nf0a921d2cde240f9a05ea5d06cd9ebc9
    27 schema:url http://link.springer.com/10.1007/978-94-007-4531-5_14
    28 sgo:license sg:explorer/license/
    29 sgo:sdDataset chapters
    30 rdf:type schema:Chapter
    31 N01369ba5ecc1432493e216f281842445 rdf:first sg:person.015375772004.39
    32 rdf:rest Ne4e49302bf064f82ae8e705d6dbd44a4
    33 N0f7644cc8943445496bd79c37381d8c5 schema:name Cellectis Therapeutics, Biopark, 8 rue de la Croix de Jarry, 75013 Paris, France
    34 rdf:type schema:Organization
    35 N175e377da46a43798bd15201754e6c86 rdf:first sg:person.01074351560.43
    36 rdf:rest rdf:nil
    37 N1b56bb8bf8f44a7c928840a41d96abff schema:familyName Duchateau
    38 schema:givenName Philippe
    39 rdf:type schema:Person
    40 N26b6016673764888bd3e625ebe73aa62 schema:name readcube_id
    41 schema:value 99c8ffee567f73ab10e446e47e220a761394a9e417fce3062f31f75e524c5cc1
    42 rdf:type schema:PropertyValue
    43 N42253908aa494f96a567fa61120883e6 rdf:first N780731f0f2984d46a28e70ac9b8bf4d6
    44 rdf:rest N175e377da46a43798bd15201754e6c86
    45 N4907359b739747f89b9757046dedf9f7 rdf:first sg:person.01343176221.23
    46 rdf:rest N42253908aa494f96a567fa61120883e6
    47 N4aa70ca633c54fc788bb412c9b2bf4d1 schema:name dimensions_id
    48 schema:value pub.1032281943
    49 rdf:type schema:PropertyValue
    50 N5f9adc4884f548608605ead999a9af32 schema:name Cellectis Bioresearch, Biopark, 8 rue de la Croix de Jarry, 75013 Paris, France
    51 rdf:type schema:Organization
    52 N60077e82e6f641b6b2dc7d3f5647d955 schema:name doi
    53 schema:value 10.1007/978-94-007-4531-5_14
    54 rdf:type schema:PropertyValue
    55 N65432464653047a9a8ccd0940da85d90 schema:familyName Renault
    56 schema:givenName Sylvaine
    57 rdf:type schema:Person
    58 N6902de3720bd4e058548610e7b8610ac rdf:first N65432464653047a9a8ccd0940da85d90
    59 rdf:rest Nbb2ce3b727974f51a0a279163135bc0d
    60 N6ed5e1218f354f649afbd80085ea3888 schema:name Cellectis Bioresearch, Biopark, 8 rue de la Croix de Jarry, 75013 Paris, France
    61 rdf:type schema:Organization
    62 N780731f0f2984d46a28e70ac9b8bf4d6 schema:affiliation https://www.grid.ac/institutes/grid.434726.0
    63 schema:familyName Balbirnie
    64 schema:givenName Edward
    65 rdf:type schema:Person
    66 N7ecb5b1920bf48889d51abd1995c92ad schema:name Cellectis Bioresearch, Biopark, 8 rue de la Croix de Jarry, 75013 Paris, France
    67 rdf:type schema:Organization
    68 Na23c69fc056443fd99afc25f63f1fb8c schema:location Dordrecht
    69 schema:name Springer Netherlands
    70 rdf:type schema:Organisation
    71 Nbb2ce3b727974f51a0a279163135bc0d rdf:first N1b56bb8bf8f44a7c928840a41d96abff
    72 rdf:rest rdf:nil
    73 Ne4e49302bf064f82ae8e705d6dbd44a4 rdf:first sg:person.01146646440.35
    74 rdf:rest N4907359b739747f89b9757046dedf9f7
    75 Ne809fa4f7b7540a690d95bf7fbc5b48d schema:isbn 978-94-007-4530-8
    76 978-94-007-4531-5
    77 schema:name Site-directed insertion of transgenes
    78 rdf:type schema:Book
    79 Nf0a921d2cde240f9a05ea5d06cd9ebc9 schema:name Springer Nature - SN SciGraph project
    80 rdf:type schema:Organization
    81 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    82 schema:name Biological Sciences
    83 rdf:type schema:DefinedTerm
    84 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
    85 schema:name Genetics
    86 rdf:type schema:DefinedTerm
    87 sg:person.01074351560.43 schema:affiliation N6ed5e1218f354f649afbd80085ea3888
    88 schema:familyName Cabaniols
    89 schema:givenName Jean-Pierre
    90 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074351560.43
    91 rdf:type schema:Person
    92 sg:person.01146646440.35 schema:affiliation N5f9adc4884f548608605ead999a9af32
    93 schema:familyName Paris
    94 schema:givenName Sébastien
    95 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01146646440.35
    96 rdf:type schema:Person
    97 sg:person.01343176221.23 schema:affiliation N0f7644cc8943445496bd79c37381d8c5
    98 schema:familyName Arnould
    99 schema:givenName Sylvain
    100 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01343176221.23
    101 rdf:type schema:Person
    102 sg:person.015375772004.39 schema:affiliation N7ecb5b1920bf48889d51abd1995c92ad
    103 schema:familyName Delenda
    104 schema:givenName Christophe
    105 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015375772004.39
    106 rdf:type schema:Person
    107 sg:pub.10.1007/3-540-29623-9_8075 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042834910
    108 https://doi.org/10.1007/3-540-29623-9_8075
    109 rdf:type schema:CreativeWork
    110 https://doi.org/10.1093/nar/gkr188 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030793292
    111 rdf:type schema:CreativeWork
    112 https://doi.org/10.1534/genetics.111.127506 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007160574
    113 rdf:type schema:CreativeWork
    114 https://doi.org/10.3791/2010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071422439
    115 rdf:type schema:CreativeWork
    116 https://www.grid.ac/institutes/grid.434726.0 schema:alternateName Genopole (France)
    117 schema:name Ectycell, 5 rue Henri Desruères, Genopole, 91030 Evry, France
    118 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...