Intracranial Ependymoma: Role for Chemotherapy View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2012

AUTHORS

Marc C. Chamberlain

ABSTRACT

Ependymomas arise from the ependymal cells of the cerebral ventricles, the central canal of the spinal cord, and cortical rests. Treatment is comprised primarily of surgery and radiotherapy with a poorly defined role for chemotherapy. Literature review relevant to treatment of ependymoma with chemotherapy. A role of chemotherapy in the management of ependymomas is controversial. Limited studies have suggested little or no benefit to chemotherapy in the up-front treatment of ependymoma. The literature regarding treatment with chemotherapy for recurrent ependymoma is meager and is comprised of studies in both children and adults. These studies indicate that chemotherapy has limited efficacy in the setting of recurrent disease and that no chemotherapy regimen has clear superiority over another albeit there is a trend for higher response rates in patients treated with platinum-based regimens. Additionally, dose-intensive chemotherapy offers no advantages over conventional dose chemotherapy in the treatment of recurrent intracranial ependymomas. No role for adjuvant chemotherapy has been demonstrated. Recurrent ependymomas are best managed by re-operation of tumors that are surgically accessible, by radiotherapy if not previously administered, and when inoperable or refractory to radiotherapy, by salvage chemotherapy. More... »

PAGES

331-338

References to SciGraph publications

Book

TITLE

Tumors of the Central Nervous System, Volume 8

ISBN

978-94-007-4212-3
978-94-007-4213-0

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-94-007-4213-0_33

DOI

http://dx.doi.org/10.1007/978-94-007-4213-0_33

DIMENSIONS

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41 schema:description Ependymomas arise from the ependymal cells of the cerebral ventricles, the central canal of the spinal cord, and cortical rests. Treatment is comprised primarily of surgery and radiotherapy with a poorly defined role for chemotherapy. Literature review relevant to treatment of ependymoma with chemotherapy. A role of chemotherapy in the management of ependymomas is controversial. Limited studies have suggested little or no benefit to chemotherapy in the up-front treatment of ependymoma. The literature regarding treatment with chemotherapy for recurrent ependymoma is meager and is comprised of studies in both children and adults. These studies indicate that chemotherapy has limited efficacy in the setting of recurrent disease and that no chemotherapy regimen has clear superiority over another albeit there is a trend for higher response rates in patients treated with platinum-based regimens. Additionally, dose-intensive chemotherapy offers no advantages over conventional dose chemotherapy in the treatment of recurrent intracranial ependymomas. No role for adjuvant chemotherapy has been demonstrated. Recurrent ependymomas are best managed by re-operation of tumors that are surgically accessible, by radiotherapy if not previously administered, and when inoperable or refractory to radiotherapy, by salvage chemotherapy.
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