Recurrent Oligodendroglioma: Treatment with Bevacizumab View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2012

AUTHORS

Marc C. Chamberlain

ABSTRACT

A retrospective literature review of bevacizumab with or without a cytotoxic partner in adults with recurrent anaplastic oligodendroglioma (AO) or oligoastrocytoma (AOA). There is no standard therapy for alkylator-resistant AO/AOA and hence a need exists for new therapies. Six papers were eligible for inclusion following a literature review in which 150 patients’ with recurrent anaplastic gliomas (47 [31%] were AO/AOA) were treated with bevacizumab. All patients had previously been treated with surgery, radiotherapy, and temozolomide-based chemotherapy. Patients were treated at first, second or third recurrence with bevacizumab, once every 2 weeks, defined as a single cycle. The majority of patients (25/47 AO/AOA; 53%) were treated with a cytotoxic chemotherapy (predominantly irinotecan) as well. The results indicated that bevacizumab-related toxicity included fatigue, epistaxis, intracranial hemorrhage, proteinuria, hypertension, deep vein thrombosis and wound dehiscence. Myelosuppression was ascribed to concomitant cytotoxic chemotherapy. 34–73% (median 68%) of all anaplastic gliomas (AG) patients demonstrated a radiographic response (complete in 11%; partial in 56%), stable disease pattern in 5–59% (median 16%) and progressive disease in 6–28% (median 9.5%) following two cycles of bevacizumab. Median, 6-month and 12-month progression free survival was 26 weeks (range 17–35), 49.5% (range 32–68%) and 23.5% (range 16–39%) respectively. In conclusion, bevacizumab, with or without a cytotoxic chemotherapy partner, demonstrates efficacy and acceptable toxicity in adults with recurrent AO/AOA. More... »

PAGES

255-265

References to SciGraph publications

Book

TITLE

Tumors of the Central Nervous System, Volume 8

ISBN

978-94-007-4212-3
978-94-007-4213-0

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-94-007-4213-0_25

DOI

http://dx.doi.org/10.1007/978-94-007-4213-0_25

DIMENSIONS

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45 schema:description A retrospective literature review of bevacizumab with or without a cytotoxic partner in adults with recurrent anaplastic oligodendroglioma (AO) or oligoastrocytoma (AOA). There is no standard therapy for alkylator-resistant AO/AOA and hence a need exists for new therapies. Six papers were eligible for inclusion following a literature review in which 150 patients’ with recurrent anaplastic gliomas (47 [31%] were AO/AOA) were treated with bevacizumab. All patients had previously been treated with surgery, radiotherapy, and temozolomide-based chemotherapy. Patients were treated at first, second or third recurrence with bevacizumab, once every 2 weeks, defined as a single cycle. The majority of patients (25/47 AO/AOA; 53%) were treated with a cytotoxic chemotherapy (predominantly irinotecan) as well. The results indicated that bevacizumab-related toxicity included fatigue, epistaxis, intracranial hemorrhage, proteinuria, hypertension, deep vein thrombosis and wound dehiscence. Myelosuppression was ascribed to concomitant cytotoxic chemotherapy. 34–73% (median 68%) of all anaplastic gliomas (AG) patients demonstrated a radiographic response (complete in 11%; partial in 56%), stable disease pattern in 5–59% (median 16%) and progressive disease in 6–28% (median 9.5%) following two cycles of bevacizumab. Median, 6-month and 12-month progression free survival was 26 weeks (range 17–35), 49.5% (range 32–68%) and 23.5% (range 16–39%) respectively. In conclusion, bevacizumab, with or without a cytotoxic chemotherapy partner, demonstrates efficacy and acceptable toxicity in adults with recurrent AO/AOA.
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