Recurrent Oligodendroglioma: Treatment with Bevacizumab View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2012

AUTHORS

Marc C. Chamberlain

ABSTRACT

A retrospective literature review of bevacizumab with or without a cytotoxic partner in adults with recurrent anaplastic oligodendroglioma (AO) or oligoastrocytoma (AOA). There is no standard therapy for alkylator-resistant AO/AOA and hence a need exists for new therapies. Six papers were eligible for inclusion following a literature review in which 150 patients’ with recurrent anaplastic gliomas (47 [31%] were AO/AOA) were treated with bevacizumab. All patients had previously been treated with surgery, radiotherapy, and temozolomide-based chemotherapy. Patients were treated at first, second or third recurrence with bevacizumab, once every 2 weeks, defined as a single cycle. The majority of patients (25/47 AO/AOA; 53%) were treated with a cytotoxic chemotherapy (predominantly irinotecan) as well. The results indicated that bevacizumab-related toxicity included fatigue, epistaxis, intracranial hemorrhage, proteinuria, hypertension, deep vein thrombosis and wound dehiscence. Myelosuppression was ascribed to concomitant cytotoxic chemotherapy. 34–73% (median 68%) of all anaplastic gliomas (AG) patients demonstrated a radiographic response (complete in 11%; partial in 56%), stable disease pattern in 5–59% (median 16%) and progressive disease in 6–28% (median 9.5%) following two cycles of bevacizumab. Median, 6-month and 12-month progression free survival was 26 weeks (range 17–35), 49.5% (range 32–68%) and 23.5% (range 16–39%) respectively. In conclusion, bevacizumab, with or without a cytotoxic chemotherapy partner, demonstrates efficacy and acceptable toxicity in adults with recurrent AO/AOA. More... »

PAGES

255-265

References to SciGraph publications

Book

TITLE

Tumors of the Central Nervous System, Volume 8

ISBN

978-94-007-4212-3
978-94-007-4213-0

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-94-007-4213-0_25

DOI

http://dx.doi.org/10.1007/978-94-007-4213-0_25

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1042876484


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Washington", 
          "id": "https://www.grid.ac/institutes/grid.34477.33", 
          "name": [
            "Department of Neurology and neurological Surgery, University of Washington, Seattle, WA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chamberlain", 
        "givenName": "Marc C.", 
        "id": "sg:person.01326261166.36", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326261166.36"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1002/cncr.20072", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000176528"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccr.2006.11.021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000989893"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-06-2309", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004441322"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(95)90755-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007598090"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(95)90755-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007598090"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2007.12.2440", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008387745"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.23404", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009553772"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0360-3016(92)90537-r", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013943845"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1014532202188", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014995762", 
          "https://doi.org/10.1023/a:1014532202188"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(02)08091-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016888626"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.11306", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020942897"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(20000801)89:3<640::aid-cncr20>3.0.co;2-e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021056940"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdg494", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023509531"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2005.04.3414", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025173270"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0360-3016(91)90676-u", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030470156"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2005.04.6078", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030668601"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19930415)71:8<2585::aid-cncr2820710825>3.0.co;2-s", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037205966"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11060-009-9957-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040541619", 
          "https://doi.org/10.1007/s11060-009-9957-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11060-009-9957-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040541619", 
          "https://doi.org/10.1007/s11060-009-9957-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/neuonc/5.2.79", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041423398"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2008.19.8721", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042965400"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.20042", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043453209"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.24179", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045011263"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-08-0260", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048254167"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa043330", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052112015"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2006.10.5825", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052985947"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2003.12.097", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064204019"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000208958.29600.87", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064348025"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000208958.29600.87", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064348025"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000208958.29600.87", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064348025"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000304121.57857.38", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064350042"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000304121.57857.38", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064350042"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/01.wnl.0000304121.57857.38", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064350042"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.0b013e3181a413be", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064354319"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.0b013e3181a413be", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064354319"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1212/wnl.0b013e3181a413be", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064354319"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1215/15228517-2005-010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064414238"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1215/15228517-2006-035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064414270"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1215/s1152851703000292", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064420609"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1215/s1152851703000607", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064420623"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/2008.4.17492", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071073905"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/2008.4.17492", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071073905"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/2008.4.17492", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071073905"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.1990.72.4.0583", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071095700"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.1990.72.4.0583", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071095700"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.1990.72.4.0583", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071095700"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.2007.106.4.601", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071102269"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.2007.106.4.601", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071102269"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3171/jns.2007.106.4.601", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071102269"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1999.17.11.3389", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074545742"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1999.17.8.2572", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074549881"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1999.17.9.2762", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074549908"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1990.8.7.1277", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078716995"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2012", 
    "datePublishedReg": "2012-01-01", 
    "description": "A retrospective literature review of bevacizumab with or without a cytotoxic partner in adults with recurrent anaplastic oligodendroglioma (AO) or oligoastrocytoma (AOA). There is no standard therapy for alkylator-resistant AO/AOA and hence a need exists for new therapies. Six papers were eligible for inclusion following a literature review in which 150 patients\u2019 with recurrent anaplastic gliomas (47 [31%] were AO/AOA) were treated with bevacizumab. All patients had previously been treated with surgery, radiotherapy, and temozolomide-based chemotherapy. Patients were treated at first, second or third recurrence with bevacizumab, once every 2 weeks, defined as a single cycle. The majority of patients (25/47 AO/AOA; 53%) were treated with a cytotoxic chemotherapy (predominantly irinotecan) as well. The results indicated that bevacizumab-related toxicity included fatigue, epistaxis, intracranial hemorrhage, proteinuria, hypertension, deep vein thrombosis and wound dehiscence. Myelosuppression was ascribed to concomitant cytotoxic chemotherapy. 34\u201373% (median 68%) of all anaplastic gliomas (AG) patients demonstrated a radiographic response (complete in 11%; partial in 56%), stable disease pattern in 5\u201359% (median 16%) and progressive disease in 6\u201328% (median 9.5%) following two cycles of bevacizumab. Median, 6-month and 12-month progression free survival was 26 weeks (range 17\u201335), 49.5% (range 32\u201368%) and 23.5% (range 16\u201339%) respectively. In conclusion, bevacizumab, with or without a cytotoxic chemotherapy partner, demonstrates efficacy and acceptable toxicity in adults with recurrent AO/AOA.", 
    "editor": [
      {
        "familyName": "Hayat", 
        "givenName": "M.A.", 
        "type": "Person"
      }
    ], 
    "genre": "chapter", 
    "id": "sg:pub.10.1007/978-94-007-4213-0_25", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": {
      "isbn": [
        "978-94-007-4212-3", 
        "978-94-007-4213-0"
      ], 
      "name": "Tumors of the Central Nervous System, Volume 8", 
      "type": "Book"
    }, 
    "name": "Recurrent Oligodendroglioma: Treatment with Bevacizumab", 
    "pagination": "255-265", 
    "productId": [
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/978-94-007-4213-0_25"
        ]
      }, 
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "cc3ce2f770357d5e04c5a6d7f0bc359b590d4b746decb51c8a773113b42b65ce"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1042876484"
        ]
      }
    ], 
    "publisher": {
      "location": "Dordrecht", 
      "name": "Springer Netherlands", 
      "type": "Organisation"
    }, 
    "sameAs": [
      "https://doi.org/10.1007/978-94-007-4213-0_25", 
      "https://app.dimensions.ai/details/publication/pub.1042876484"
    ], 
    "sdDataset": "chapters", 
    "sdDatePublished": "2019-04-15T16:19", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8675_00000269.jsonl", 
    "type": "Chapter", 
    "url": "http://link.springer.com/10.1007/978-94-007-4213-0_25"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-94-007-4213-0_25'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-94-007-4213-0_25'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-94-007-4213-0_25'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-94-007-4213-0_25'


 

This table displays all metadata directly associated to this object as RDF triples.

184 TRIPLES      23 PREDICATES      66 URIs      20 LITERALS      8 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/978-94-007-4213-0_25 schema:about anzsrc-for:11
2 anzsrc-for:1112
3 schema:author Nf2dac125e5fd457d90aa35dff6131bed
4 schema:citation sg:pub.10.1007/s11060-009-9957-6
5 sg:pub.10.1023/a:1014532202188
6 https://doi.org/10.1002/1097-0142(19930415)71:8<2585::aid-cncr2820710825>3.0.co;2-s
7 https://doi.org/10.1002/1097-0142(20000801)89:3<640::aid-cncr20>3.0.co;2-e
8 https://doi.org/10.1002/cncr.11306
9 https://doi.org/10.1002/cncr.20042
10 https://doi.org/10.1002/cncr.20072
11 https://doi.org/10.1002/cncr.23404
12 https://doi.org/10.1002/cncr.24179
13 https://doi.org/10.1016/0360-3016(91)90676-u
14 https://doi.org/10.1016/0360-3016(92)90537-r
15 https://doi.org/10.1016/j.ccr.2006.11.021
16 https://doi.org/10.1016/s0140-6736(02)08091-1
17 https://doi.org/10.1016/s0140-6736(95)90755-6
18 https://doi.org/10.1056/nejmoa043330
19 https://doi.org/10.1093/annonc/mdg494
20 https://doi.org/10.1093/neuonc/5.2.79
21 https://doi.org/10.1158/1078-0432.ccr-06-2309
22 https://doi.org/10.1158/1078-0432.ccr-08-0260
23 https://doi.org/10.1200/jco.1990.8.7.1277
24 https://doi.org/10.1200/jco.1999.17.11.3389
25 https://doi.org/10.1200/jco.1999.17.8.2572
26 https://doi.org/10.1200/jco.1999.17.9.2762
27 https://doi.org/10.1200/jco.2003.12.097
28 https://doi.org/10.1200/jco.2005.04.3414
29 https://doi.org/10.1200/jco.2005.04.6078
30 https://doi.org/10.1200/jco.2006.10.5825
31 https://doi.org/10.1200/jco.2007.12.2440
32 https://doi.org/10.1200/jco.2008.19.8721
33 https://doi.org/10.1212/01.wnl.0000208958.29600.87
34 https://doi.org/10.1212/01.wnl.0000304121.57857.38
35 https://doi.org/10.1212/wnl.0b013e3181a413be
36 https://doi.org/10.1215/15228517-2005-010
37 https://doi.org/10.1215/15228517-2006-035
38 https://doi.org/10.1215/s1152851703000292
39 https://doi.org/10.1215/s1152851703000607
40 https://doi.org/10.3171/2008.4.17492
41 https://doi.org/10.3171/jns.1990.72.4.0583
42 https://doi.org/10.3171/jns.2007.106.4.601
43 schema:datePublished 2012
44 schema:datePublishedReg 2012-01-01
45 schema:description A retrospective literature review of bevacizumab with or without a cytotoxic partner in adults with recurrent anaplastic oligodendroglioma (AO) or oligoastrocytoma (AOA). There is no standard therapy for alkylator-resistant AO/AOA and hence a need exists for new therapies. Six papers were eligible for inclusion following a literature review in which 150 patients’ with recurrent anaplastic gliomas (47 [31%] were AO/AOA) were treated with bevacizumab. All patients had previously been treated with surgery, radiotherapy, and temozolomide-based chemotherapy. Patients were treated at first, second or third recurrence with bevacizumab, once every 2 weeks, defined as a single cycle. The majority of patients (25/47 AO/AOA; 53%) were treated with a cytotoxic chemotherapy (predominantly irinotecan) as well. The results indicated that bevacizumab-related toxicity included fatigue, epistaxis, intracranial hemorrhage, proteinuria, hypertension, deep vein thrombosis and wound dehiscence. Myelosuppression was ascribed to concomitant cytotoxic chemotherapy. 34–73% (median 68%) of all anaplastic gliomas (AG) patients demonstrated a radiographic response (complete in 11%; partial in 56%), stable disease pattern in 5–59% (median 16%) and progressive disease in 6–28% (median 9.5%) following two cycles of bevacizumab. Median, 6-month and 12-month progression free survival was 26 weeks (range 17–35), 49.5% (range 32–68%) and 23.5% (range 16–39%) respectively. In conclusion, bevacizumab, with or without a cytotoxic chemotherapy partner, demonstrates efficacy and acceptable toxicity in adults with recurrent AO/AOA.
46 schema:editor N2b5183dda57c445587209f1ce0e6a4f0
47 schema:genre chapter
48 schema:inLanguage en
49 schema:isAccessibleForFree false
50 schema:isPartOf N29a8aa3d158442c6b7c32a08ce334799
51 schema:name Recurrent Oligodendroglioma: Treatment with Bevacizumab
52 schema:pagination 255-265
53 schema:productId N39276fc3669b4a66a810902852f75d17
54 N8be1e9e460e044c2a5b7cd6d58edada0
55 Nae4a5f617ac742c5980ea26acb96f4f7
56 schema:publisher Nbb34df2f41ea4bfeb893543fbd8a99a4
57 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042876484
58 https://doi.org/10.1007/978-94-007-4213-0_25
59 schema:sdDatePublished 2019-04-15T16:19
60 schema:sdLicense https://scigraph.springernature.com/explorer/license/
61 schema:sdPublisher Nfbcf22b74742442ba9ce08d24ef6caf1
62 schema:url http://link.springer.com/10.1007/978-94-007-4213-0_25
63 sgo:license sg:explorer/license/
64 sgo:sdDataset chapters
65 rdf:type schema:Chapter
66 N29a8aa3d158442c6b7c32a08ce334799 schema:isbn 978-94-007-4212-3
67 978-94-007-4213-0
68 schema:name Tumors of the Central Nervous System, Volume 8
69 rdf:type schema:Book
70 N2b5183dda57c445587209f1ce0e6a4f0 rdf:first N94d99eec970d4df687f3875dadf90bc6
71 rdf:rest rdf:nil
72 N39276fc3669b4a66a810902852f75d17 schema:name dimensions_id
73 schema:value pub.1042876484
74 rdf:type schema:PropertyValue
75 N8be1e9e460e044c2a5b7cd6d58edada0 schema:name readcube_id
76 schema:value cc3ce2f770357d5e04c5a6d7f0bc359b590d4b746decb51c8a773113b42b65ce
77 rdf:type schema:PropertyValue
78 N94d99eec970d4df687f3875dadf90bc6 schema:familyName Hayat
79 schema:givenName M.A.
80 rdf:type schema:Person
81 Nae4a5f617ac742c5980ea26acb96f4f7 schema:name doi
82 schema:value 10.1007/978-94-007-4213-0_25
83 rdf:type schema:PropertyValue
84 Nbb34df2f41ea4bfeb893543fbd8a99a4 schema:location Dordrecht
85 schema:name Springer Netherlands
86 rdf:type schema:Organisation
87 Nf2dac125e5fd457d90aa35dff6131bed rdf:first sg:person.01326261166.36
88 rdf:rest rdf:nil
89 Nfbcf22b74742442ba9ce08d24ef6caf1 schema:name Springer Nature - SN SciGraph project
90 rdf:type schema:Organization
91 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
92 schema:name Medical and Health Sciences
93 rdf:type schema:DefinedTerm
94 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
95 schema:name Oncology and Carcinogenesis
96 rdf:type schema:DefinedTerm
97 sg:person.01326261166.36 schema:affiliation https://www.grid.ac/institutes/grid.34477.33
98 schema:familyName Chamberlain
99 schema:givenName Marc C.
100 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326261166.36
101 rdf:type schema:Person
102 sg:pub.10.1007/s11060-009-9957-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040541619
103 https://doi.org/10.1007/s11060-009-9957-6
104 rdf:type schema:CreativeWork
105 sg:pub.10.1023/a:1014532202188 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014995762
106 https://doi.org/10.1023/a:1014532202188
107 rdf:type schema:CreativeWork
108 https://doi.org/10.1002/1097-0142(19930415)71:8<2585::aid-cncr2820710825>3.0.co;2-s schema:sameAs https://app.dimensions.ai/details/publication/pub.1037205966
109 rdf:type schema:CreativeWork
110 https://doi.org/10.1002/1097-0142(20000801)89:3<640::aid-cncr20>3.0.co;2-e schema:sameAs https://app.dimensions.ai/details/publication/pub.1021056940
111 rdf:type schema:CreativeWork
112 https://doi.org/10.1002/cncr.11306 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020942897
113 rdf:type schema:CreativeWork
114 https://doi.org/10.1002/cncr.20042 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043453209
115 rdf:type schema:CreativeWork
116 https://doi.org/10.1002/cncr.20072 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000176528
117 rdf:type schema:CreativeWork
118 https://doi.org/10.1002/cncr.23404 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009553772
119 rdf:type schema:CreativeWork
120 https://doi.org/10.1002/cncr.24179 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045011263
121 rdf:type schema:CreativeWork
122 https://doi.org/10.1016/0360-3016(91)90676-u schema:sameAs https://app.dimensions.ai/details/publication/pub.1030470156
123 rdf:type schema:CreativeWork
124 https://doi.org/10.1016/0360-3016(92)90537-r schema:sameAs https://app.dimensions.ai/details/publication/pub.1013943845
125 rdf:type schema:CreativeWork
126 https://doi.org/10.1016/j.ccr.2006.11.021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000989893
127 rdf:type schema:CreativeWork
128 https://doi.org/10.1016/s0140-6736(02)08091-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016888626
129 rdf:type schema:CreativeWork
130 https://doi.org/10.1016/s0140-6736(95)90755-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007598090
131 rdf:type schema:CreativeWork
132 https://doi.org/10.1056/nejmoa043330 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052112015
133 rdf:type schema:CreativeWork
134 https://doi.org/10.1093/annonc/mdg494 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023509531
135 rdf:type schema:CreativeWork
136 https://doi.org/10.1093/neuonc/5.2.79 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041423398
137 rdf:type schema:CreativeWork
138 https://doi.org/10.1158/1078-0432.ccr-06-2309 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004441322
139 rdf:type schema:CreativeWork
140 https://doi.org/10.1158/1078-0432.ccr-08-0260 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048254167
141 rdf:type schema:CreativeWork
142 https://doi.org/10.1200/jco.1990.8.7.1277 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078716995
143 rdf:type schema:CreativeWork
144 https://doi.org/10.1200/jco.1999.17.11.3389 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074545742
145 rdf:type schema:CreativeWork
146 https://doi.org/10.1200/jco.1999.17.8.2572 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074549881
147 rdf:type schema:CreativeWork
148 https://doi.org/10.1200/jco.1999.17.9.2762 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074549908
149 rdf:type schema:CreativeWork
150 https://doi.org/10.1200/jco.2003.12.097 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064204019
151 rdf:type schema:CreativeWork
152 https://doi.org/10.1200/jco.2005.04.3414 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025173270
153 rdf:type schema:CreativeWork
154 https://doi.org/10.1200/jco.2005.04.6078 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030668601
155 rdf:type schema:CreativeWork
156 https://doi.org/10.1200/jco.2006.10.5825 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052985947
157 rdf:type schema:CreativeWork
158 https://doi.org/10.1200/jco.2007.12.2440 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008387745
159 rdf:type schema:CreativeWork
160 https://doi.org/10.1200/jco.2008.19.8721 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042965400
161 rdf:type schema:CreativeWork
162 https://doi.org/10.1212/01.wnl.0000208958.29600.87 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064348025
163 rdf:type schema:CreativeWork
164 https://doi.org/10.1212/01.wnl.0000304121.57857.38 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064350042
165 rdf:type schema:CreativeWork
166 https://doi.org/10.1212/wnl.0b013e3181a413be schema:sameAs https://app.dimensions.ai/details/publication/pub.1064354319
167 rdf:type schema:CreativeWork
168 https://doi.org/10.1215/15228517-2005-010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064414238
169 rdf:type schema:CreativeWork
170 https://doi.org/10.1215/15228517-2006-035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064414270
171 rdf:type schema:CreativeWork
172 https://doi.org/10.1215/s1152851703000292 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064420609
173 rdf:type schema:CreativeWork
174 https://doi.org/10.1215/s1152851703000607 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064420623
175 rdf:type schema:CreativeWork
176 https://doi.org/10.3171/2008.4.17492 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071073905
177 rdf:type schema:CreativeWork
178 https://doi.org/10.3171/jns.1990.72.4.0583 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071095700
179 rdf:type schema:CreativeWork
180 https://doi.org/10.3171/jns.2007.106.4.601 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071102269
181 rdf:type schema:CreativeWork
182 https://www.grid.ac/institutes/grid.34477.33 schema:alternateName University of Washington
183 schema:name Department of Neurology and neurological Surgery, University of Washington, Seattle, WA, USA
184 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...