Riboflavin in Development and Cell Fate View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2011-08-31

AUTHORS

Hilary J. Powers , B.M. Corfe , E. Nakano

ABSTRACT

Riboflavin (7,8-dimethyl-10-ribitylisoalloxazine; vitamin B2) is a water-soluble vitamin, cofactor derivatives of which (FAD, FMN) act as electron acceptors in the oxidative metabolism of carbohydrate, amino acids and fatty acids and which in the reduced state can donate electrons to complex II of the electron transport chain. This means that riboflavin is essential for energy generation in the aerobic cell, through oxidative phosphorylation. The classic effects of riboflavin deficiency on growth and development have generally been explained in terms of these functions. However, research also suggests that riboflavin may have specific functions associated with cell fate determination, which would have implications for growth and development. In particular, riboflavin depletion interferes with the normal progression of the cell cycle, probably through effects on the expression of regulatory genes, exerted at both the transcriptional and proteomic level. More... »

PAGES

229-245

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-94-007-2199-9_12

DOI

http://dx.doi.org/10.1007/978-94-007-2199-9_12

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1009268629

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22116702


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Cycle", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Differentiation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Enterocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gastrointestinal Tract", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Growth and Development", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Riboflavin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Riboflavin Deficiency", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Human Nutrition Unit, The School of Medicine, The University of Sheffield, S10 2RX, Sheffield, UK", 
          "id": "http://www.grid.ac/institutes/grid.11835.3e", 
          "name": [
            "Human Nutrition Unit, The School of Medicine, The University of Sheffield, S10 2RX, Sheffield, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Powers", 
        "givenName": "Hilary J.", 
        "id": "sg:person.01262102673.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01262102673.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Human Nutrition Unit, The School of Medicine, The University of Sheffield, S10 2RX, Sheffield, UK", 
          "id": "http://www.grid.ac/institutes/grid.11835.3e", 
          "name": [
            "Human Nutrition Unit, The School of Medicine, The University of Sheffield, S10 2RX, Sheffield, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Corfe", 
        "givenName": "B.M.", 
        "id": "sg:person.01322020151.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01322020151.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Human Nutrition Unit, The School of Medicine, The University of Sheffield, S10 2RX, Sheffield, UK", 
          "id": "http://www.grid.ac/institutes/grid.11835.3e", 
          "name": [
            "Human Nutrition Unit, The School of Medicine, The University of Sheffield, S10 2RX, Sheffield, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nakano", 
        "givenName": "E.", 
        "id": "sg:person.01043613603.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01043613603.01"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "2011-08-31", 
    "datePublishedReg": "2011-08-31", 
    "description": "Riboflavin (7,8-dimethyl-10-ribitylisoalloxazine; vitamin B2) is a water-soluble vitamin, cofactor derivatives of which (FAD, FMN) act as electron acceptors in the oxidative metabolism of carbohydrate, amino acids and fatty acids and which in the reduced state can donate electrons to complex II of the electron transport chain. This means that riboflavin is essential for energy generation in the aerobic cell, through oxidative phosphorylation. The classic effects of riboflavin deficiency on growth and development have generally been explained in terms of these functions. However, research also suggests that riboflavin may have specific functions associated with cell fate determination, which would have implications for growth and development. In particular, riboflavin depletion interferes with the normal progression of the cell cycle, probably through effects on the expression of regulatory genes, exerted at both the transcriptional and proteomic level.", 
    "editor": [
      {
        "familyName": "Stanger", 
        "givenName": "Olaf", 
        "type": "Person"
      }
    ], 
    "genre": "chapter", 
    "id": "sg:pub.10.1007/978-94-007-2199-9_12", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": {
      "isbn": [
        "978-94-007-2198-2", 
        "978-94-007-2199-9"
      ], 
      "name": "Water Soluble Vitamins", 
      "type": "Book"
    }, 
    "keywords": [
      "cell fate determination", 
      "electron transport chain", 
      "fate determination", 
      "cell fate", 
      "regulatory genes", 
      "proteomic level", 
      "transport chain", 
      "cell cycle", 
      "oxidative phosphorylation", 
      "specific functions", 
      "normal progression", 
      "aerobic cells", 
      "amino acids", 
      "cofactor derivatives", 
      "electron acceptor", 
      "fatty acids", 
      "oxidative metabolism", 
      "phosphorylation", 
      "genes", 
      "growth", 
      "water-soluble vitamins", 
      "riboflavin depletion", 
      "acid", 
      "fate", 
      "expression", 
      "metabolism", 
      "cells", 
      "riboflavin", 
      "function", 
      "development", 
      "carbohydrates", 
      "depletion", 
      "acceptor", 
      "progression", 
      "cycle", 
      "deficiency", 
      "energy generation", 
      "riboflavin deficiency", 
      "chain", 
      "vitamin", 
      "levels", 
      "effect", 
      "generation", 
      "act", 
      "classic effects", 
      "implications", 
      "derivatives", 
      "determination", 
      "state", 
      "research", 
      "terms", 
      "electrons"
    ], 
    "name": "Riboflavin in Development and Cell Fate", 
    "pagination": "229-245", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1009268629"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/978-94-007-2199-9_12"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "22116702"
        ]
      }
    ], 
    "publisher": {
      "name": "Springer Nature", 
      "type": "Organisation"
    }, 
    "sameAs": [
      "https://doi.org/10.1007/978-94-007-2199-9_12", 
      "https://app.dimensions.ai/details/publication/pub.1009268629"
    ], 
    "sdDataset": "chapters", 
    "sdDatePublished": "2022-01-01T19:13", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/chapter/chapter_223.jsonl", 
    "type": "Chapter", 
    "url": "https://doi.org/10.1007/978-94-007-2199-9_12"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-94-007-2199-9_12'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-94-007-2199-9_12'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-94-007-2199-9_12'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-94-007-2199-9_12'


 

This table displays all metadata directly associated to this object as RDF triples.

170 TRIPLES      23 PREDICATES      88 URIs      80 LITERALS      17 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/978-94-007-2199-9_12 schema:about N181ee99ca219410cb2ab34c7bac90ccf
2 N2cd313b1f84047aea55f1a40e1a0cdde
3 N3945582cc3ba49078685c36809f41f5c
4 N89a5b607909e4a5aa6689547a1633c8d
5 Na0d00730815d4910ad1daa8884c661da
6 Ndab147ba3c234d00a39f4880d0f3778b
7 Nde3e24f7234f4fe48efd687961a57f8b
8 Ne104d20efac047a6a047f6c0f3fefe10
9 Nf1bf726bf61e4cf4bd90abeed5f6b0f0
10 anzsrc-for:06
11 anzsrc-for:0601
12 anzsrc-for:0604
13 schema:author Nf80f032ceed24085b8c130758b14c560
14 schema:datePublished 2011-08-31
15 schema:datePublishedReg 2011-08-31
16 schema:description Riboflavin (7,8-dimethyl-10-ribitylisoalloxazine; vitamin B2) is a water-soluble vitamin, cofactor derivatives of which (FAD, FMN) act as electron acceptors in the oxidative metabolism of carbohydrate, amino acids and fatty acids and which in the reduced state can donate electrons to complex II of the electron transport chain. This means that riboflavin is essential for energy generation in the aerobic cell, through oxidative phosphorylation. The classic effects of riboflavin deficiency on growth and development have generally been explained in terms of these functions. However, research also suggests that riboflavin may have specific functions associated with cell fate determination, which would have implications for growth and development. In particular, riboflavin depletion interferes with the normal progression of the cell cycle, probably through effects on the expression of regulatory genes, exerted at both the transcriptional and proteomic level.
17 schema:editor N7fcd9eb999914f20b9e3d62dc6c60b3f
18 schema:genre chapter
19 schema:inLanguage en
20 schema:isAccessibleForFree false
21 schema:isPartOf N27cc3ae8640d425ba21fbf81aba8ed26
22 schema:keywords acceptor
23 acid
24 act
25 aerobic cells
26 amino acids
27 carbohydrates
28 cell cycle
29 cell fate
30 cell fate determination
31 cells
32 chain
33 classic effects
34 cofactor derivatives
35 cycle
36 deficiency
37 depletion
38 derivatives
39 determination
40 development
41 effect
42 electron acceptor
43 electron transport chain
44 electrons
45 energy generation
46 expression
47 fate
48 fate determination
49 fatty acids
50 function
51 generation
52 genes
53 growth
54 implications
55 levels
56 metabolism
57 normal progression
58 oxidative metabolism
59 oxidative phosphorylation
60 phosphorylation
61 progression
62 proteomic level
63 regulatory genes
64 research
65 riboflavin
66 riboflavin deficiency
67 riboflavin depletion
68 specific functions
69 state
70 terms
71 transport chain
72 vitamin
73 water-soluble vitamins
74 schema:name Riboflavin in Development and Cell Fate
75 schema:pagination 229-245
76 schema:productId N2665ff4431ac485090a1687047e9dd69
77 N574105def44a4bed8e97d84fdef814c0
78 N7d3a1577bd4245b582884d57aaee770f
79 schema:publisher N9bd03d7d3d084ed5b99cf83a705f16fa
80 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009268629
81 https://doi.org/10.1007/978-94-007-2199-9_12
82 schema:sdDatePublished 2022-01-01T19:13
83 schema:sdLicense https://scigraph.springernature.com/explorer/license/
84 schema:sdPublisher N11a7c8cc79544eeda4a216b93a0d673c
85 schema:url https://doi.org/10.1007/978-94-007-2199-9_12
86 sgo:license sg:explorer/license/
87 sgo:sdDataset chapters
88 rdf:type schema:Chapter
89 N11a7c8cc79544eeda4a216b93a0d673c schema:name Springer Nature - SN SciGraph project
90 rdf:type schema:Organization
91 N181ee99ca219410cb2ab34c7bac90ccf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Animals
93 rdf:type schema:DefinedTerm
94 N2665ff4431ac485090a1687047e9dd69 schema:name dimensions_id
95 schema:value pub.1009268629
96 rdf:type schema:PropertyValue
97 N27cc3ae8640d425ba21fbf81aba8ed26 schema:isbn 978-94-007-2198-2
98 978-94-007-2199-9
99 schema:name Water Soluble Vitamins
100 rdf:type schema:Book
101 N288f379c01144424ba83dbb693221e7d rdf:first sg:person.01043613603.01
102 rdf:rest rdf:nil
103 N2cd313b1f84047aea55f1a40e1a0cdde schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Humans
105 rdf:type schema:DefinedTerm
106 N3945582cc3ba49078685c36809f41f5c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Gastrointestinal Tract
108 rdf:type schema:DefinedTerm
109 N574105def44a4bed8e97d84fdef814c0 schema:name pubmed_id
110 schema:value 22116702
111 rdf:type schema:PropertyValue
112 N7d3a1577bd4245b582884d57aaee770f schema:name doi
113 schema:value 10.1007/978-94-007-2199-9_12
114 rdf:type schema:PropertyValue
115 N7fcd9eb999914f20b9e3d62dc6c60b3f rdf:first N980101077b61406c965130998c58e5d1
116 rdf:rest rdf:nil
117 N829aeaaecc4d491691738a585be57e9f rdf:first sg:person.01322020151.91
118 rdf:rest N288f379c01144424ba83dbb693221e7d
119 N89a5b607909e4a5aa6689547a1633c8d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Riboflavin
121 rdf:type schema:DefinedTerm
122 N980101077b61406c965130998c58e5d1 schema:familyName Stanger
123 schema:givenName Olaf
124 rdf:type schema:Person
125 N9bd03d7d3d084ed5b99cf83a705f16fa schema:name Springer Nature
126 rdf:type schema:Organisation
127 Na0d00730815d4910ad1daa8884c661da schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Growth and Development
129 rdf:type schema:DefinedTerm
130 Ndab147ba3c234d00a39f4880d0f3778b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Cell Differentiation
132 rdf:type schema:DefinedTerm
133 Nde3e24f7234f4fe48efd687961a57f8b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Cell Cycle
135 rdf:type schema:DefinedTerm
136 Ne104d20efac047a6a047f6c0f3fefe10 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Riboflavin Deficiency
138 rdf:type schema:DefinedTerm
139 Nf1bf726bf61e4cf4bd90abeed5f6b0f0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Enterocytes
141 rdf:type schema:DefinedTerm
142 Nf80f032ceed24085b8c130758b14c560 rdf:first sg:person.01262102673.15
143 rdf:rest N829aeaaecc4d491691738a585be57e9f
144 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
145 schema:name Biological Sciences
146 rdf:type schema:DefinedTerm
147 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
148 schema:name Biochemistry and Cell Biology
149 rdf:type schema:DefinedTerm
150 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
151 schema:name Genetics
152 rdf:type schema:DefinedTerm
153 sg:person.01043613603.01 schema:affiliation grid-institutes:grid.11835.3e
154 schema:familyName Nakano
155 schema:givenName E.
156 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01043613603.01
157 rdf:type schema:Person
158 sg:person.01262102673.15 schema:affiliation grid-institutes:grid.11835.3e
159 schema:familyName Powers
160 schema:givenName Hilary J.
161 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01262102673.15
162 rdf:type schema:Person
163 sg:person.01322020151.91 schema:affiliation grid-institutes:grid.11835.3e
164 schema:familyName Corfe
165 schema:givenName B.M.
166 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01322020151.91
167 rdf:type schema:Person
168 grid-institutes:grid.11835.3e schema:alternateName Human Nutrition Unit, The School of Medicine, The University of Sheffield, S10 2RX, Sheffield, UK
169 schema:name Human Nutrition Unit, The School of Medicine, The University of Sheffield, S10 2RX, Sheffield, UK
170 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...