Central Nervous System Rosai–Dorfman Disease View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2010-08-07

AUTHORS

Osama Raslan , Leena M. Ketonen , Gregory N. Fuller , Dawid Schellingerhout

ABSTRACT

In 1969, Rosai and Dorfman described the triad of massive cervical lymphadenopathy, expanded lymph node sinuses and characteristic histiocytes showing “emperipolesis” as a new, rare, idiopathic, nonneoplastic, lymphoproliferative disorder known as Rosai Dorfman Disease (RDD) or ‘sinus histiocytosis with massive lymphadenopathy (SHML) (Rosai and Dorfman 1969). Since then, over 750 cases have been reported in the literature (Hargett and Bassett 2005). Typically, RDD is characterized by bilateral painless cervical lymphadenopathy with fever, leukocytosis, increased erythrocyte sedimentation rate and hypergammaglobulinaemia (Chopra et al. 2006). However, in approximately 40% of cases, extranodal lesions in the skin, upper respiratory tract, orbit, testicle, soft tissue, kidney, thyroid, small bowel, breast, and bone can be found (Ruggiero et al. 2006). More... »

PAGES

365-373

Book

TITLE

Methods of Cancer Diagnosis, Therapy, and Prognosis

ISBN

978-90-481-8664-8
978-90-481-8665-5

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-90-481-8665-5_28

DOI

http://dx.doi.org/10.1007/978-90-481-8665-5_28

DIMENSIONS

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