Size Dependent Heat Generation of Magnetic Nanoparticles Under AC Magnetic Field for Cancer Therapy View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2010-03-03

AUTHORS

Jun Motoyama , Toshiyuki Hakata , Ryuji Kato , Noriyuki Yamashita , Tomio Morino , Takeshi Kobayashi , Hiroyuki Honda

ABSTRACT

Hyperthermia or Thermal therapy is a type of cancer treatment in which body tissue is exposed to high temperatures to damage and kill cancer cells. For years, a lot of studies are conducted in various application methods and various temperature ranges. We used magnetite nanoparticles as a heating mediator for applying them to local hyperthermia. Magnetite nanoparticles are formed into cationic liposome to increase the affinity of the tumor cells by its charged surfaces. However, heating performance of the MCL is significantly affected by the nature of the incorporated magnetite nanoparticles. We estimated heating capacity of those materials by measuring its specific absorption rate (SAR) against irradiation of the alternating magnetic field. As a result, we observed some corresponding relations between the heating performance and the specific surface area (SSA) of internal magnetic nanoparticles. And also observed the mechanism of heat generation of magnetite nanoparticles appeared differently in the vicinity of 110 m2/g of the SSA. We used newly refined magnetic nanoparticles to form the MCL, and treated a spontaneous cancer model by them. More... »

PAGES

415-421

References to SciGraph publications

Book

TITLE

Basic and Applied Aspects

ISBN

978-90-481-3891-3
978-90-481-3892-0

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-90-481-3892-0_68

DOI

http://dx.doi.org/10.1007/978-90-481-3892-0_68

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1009479034


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