Chemical Construction of Polyfunctional Nanocomposites and Nanorobots for Medico-biological Applications View Full Text


Ontology type: schema:Chapter      Open Access: True


Chapter Info

DATE

2009-08-21

AUTHORS

P.P. Gorbyk , I.V. Dubrovin , A.L. Petranovska , M.V. Abramov , D.G. Usov , L.P. Storozhuk , S.P. Turanska , M.P. Turelyk , V.F. Chekhun , N.Yu. Lukyanova , A.P. Shpak , O.M. Korduban

ABSTRACT

A method for preparation of magnetosensitive nanocomposites on the basis of surface-modified magnetite carrying immobilized cisplatin and monoclonal antibody CD 95 (a medico-biological nanorobot model) was developed. Adsorption and covalent immobilization of monoclonal antibody CD 95 and human normal immunoglobulin on nanocomposites comprising magnetite coated with poly(acryl amide) and γ-aminopropylsiloxane was studied. Isotherms of covalent attachment of oxidized immunoglobulin via formation of Schiff bases and non-specific (physical) adsorption of the normal immunoglobulin were compared. Kinetics of release of the immunoglobulin to a model environment was studied. Interaction of the prepared models of nanorobots with the cell line MCF-7 was studied. It was shown that use of magnetically driven nanocomposites carrying the anti-tumour drug and the monoclonal antibody CD 95 causes a synergic cytotoxic effect which exceeds the influence of the control doses up to 50%. More... »

PAGES

63-78

Book

TITLE

Nanomaterials and Supramolecular Structures

ISBN

978-90-481-2308-7
978-90-481-2309-4

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-90-481-2309-4_6

DOI

http://dx.doi.org/10.1007/978-90-481-2309-4_6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1005448468


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