Infectious Complications View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2010

AUTHORS

Nicola Petrosillo , Cecilia M. J. Drapeau

ABSTRACT

Infections are strongly associated with Crohn’s disease (CD), both in their etiopathogenesis and in their clinical course [1]. The hypothesis that infective agents are linked to the onset of CD is supported by several clinical and experimental observations, although a direct causality remains to be demonstrated. In particular, bacteria such as Mycobacterium avium subsp. paratuberculosis (MAP), adherent invasive Escherichia coli (AIEC), and Listeria spp. have been cited as possible causal agents of CD [1–3]. This conclusion is based on the association of MAP DNA and CD, reported in two meta-analyses [4,5]. Moreover, experimental infections of animals have demonstrated that MAP is capable of causing inflammatory bowel disease [2]. Other investigations have reported the presence of AIEC in CD biopsies and a mechanism of attachment to the diseased bowel [2,3]. More... »

PAGES

239-248

Book

TITLE

Crohn’s Disease

ISBN

978-88-470-1471-8
978-88-470-1472-5

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-88-470-1472-5_22

DOI

http://dx.doi.org/10.1007/978-88-470-1472-5_22

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1019436265


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