Neuroprotective Strategies View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2012

AUTHORS

Angela M. Kaindl , Géraldine Favrais , Pierre Gressens

ABSTRACT

The mortality of infants, especially premature infants, has decreased remarkably in recent decades, but their morbidity has not followed the path at the same pace. Thus, neurocognitive morbidity, especially following premature birth, is a dominating health care issue. While the development of strategies to improve the neurologic outcome of infants suffering from perinatal brain damage is thereby essential, currently available intervention strategies are limited. Perinatal brain damage is believed to be a multifactorial, multihit process that varies in severity between individuals, affects infants of different genetic backgrounds and occurs at various stages of the physiological developmental program (Fig. 137.1). This said, it becomes clear that the respective pathologies, even following one type of injury, are likely multiple. Patterns of brain lesions depend on developmental stage. Periventricular leucomalacia is particularly frequent in the premature infant, while hypoxicischemic encephalopathy affects predominantly the term infant. The development of novel neuroprotective strategies thereby demands a clear understanding of the pathophysiology of each of the disorders in order to identify readouts or targets/ pathways to test for the efficacy of candidate molecules. Since many developmental processes underlie a fine balance, careful attention needs to be paid to acute and long-term toxic effects. It remains to be elucidated, for example, when a decrease of apoptotic cell death is beneficial or detrimental. More... »

PAGES

1173-1179

References to SciGraph publications

Book

TITLE

Neonatology

ISBN

978-88-470-1404-6
978-88-470-1405-3

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-88-470-1405-3_137

DOI

http://dx.doi.org/10.1007/978-88-470-1405-3_137

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1047000664


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