Melatonergic Drug: Ramelteon and Its Therapeutic Applications in Insomnia View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2014

AUTHORS

Venkataramanujam Srinivasan , Rahimah Zakaria , Timo Partonen , Edward C. Lauterbach , Preetha Sharone Kuppuswamy , Amnon Brzezinski , Zahiruddin Othman , Atul Prasad

ABSTRACT

The efficacy of melatonin in promoting and maintaining sleep has been demonstrated in most of the clinical studies. However, because of its short half-life, its sustained effect in improving sleep quality could not be demonstrated uniformly in all the studies that have been undertaken so far. The development of slow-release melatonin preparation Circadin has been found effective in reducing sleep onset time and also for improving sleep quality. This was followed by the introduction of another melatonergic drug ramelteon a melatonin receptor agonist that has high selectivity for MT1 receptors than MT2 receptors and therefore targets sleep onset more specifically than melatonin. Clinical trials undertaken in different countries of European region and Japan have conclusively demonstrated that ramelteon in various doses (from 4 to 32 mg/day) reduced sleep onset latency, increased total sleep time, and sleep efficiency and quality in patients suffering from chronic insomnia. Besides acting as a sedative-hypnotic drug, ramelteon also demonstrated its ability as a drug with chronobiotic properties and has been found useful in resetting the disturbed circadian rhythms. The action of ramelteon in improving sleep efficiency is dose independent and hence acts differently from melatonin. It has a promising value in treating patients with chronic insomnia as it does not have any of the adverse effects like next-day hangover and dependence associated with the usage of other conventional hypnotic drugs. More... »

PAGES

343-352

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-81-322-0825-9_24

DOI

http://dx.doi.org/10.1007/978-81-322-0825-9_24

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1013406076


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1115", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Pharmacology and Pharmaceutical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Sri Sathya Sai Medical Educational and Research Foundation, An International Medical Sciences Research Study Center, Prasanthi Nilayam, 40-Kovai Thirunagar Extn, Goldwins, Coimbatore, TN, 641014, India"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Srinivasan", 
        "givenName": "Venkataramanujam", 
        "id": "sg:person.01237721775.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01237721775.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Universiti Sains Malaysia", 
          "id": "https://www.grid.ac/institutes/grid.11875.3a", 
          "name": [
            "Department of Physiology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, 16150, Malaysia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zakaria", 
        "givenName": "Rahimah", 
        "id": "sg:person.01224603156.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224603156.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Institute for Health and Welfare", 
          "id": "https://www.grid.ac/institutes/grid.14758.3f", 
          "name": [
            "Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Mannerheimintie 166, FI-00300\u00a0Helsinki, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Partonen", 
        "givenName": "Timo", 
        "id": "sg:person.01112354114.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01112354114.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Mercer University", 
          "id": "https://www.grid.ac/institutes/grid.259906.1", 
          "name": [
            "Department of Psychiatry and Behavioral Sciences, and the Department of Internal Medicine, Neurology Section, Mercer University School of Medicine, 655 First Street, Macon, GA\u00a031201, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lauterbach", 
        "givenName": "Edward C.", 
        "id": "sg:person.0632502703.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632502703.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Mayo Clinic", 
          "id": "https://www.grid.ac/institutes/grid.66875.3a", 
          "name": [
            "Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN\u00a055905, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kuppuswamy", 
        "givenName": "Preetha Sharone", 
        "id": "sg:person.0735115013.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735115013.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hadassah Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.17788.31", 
          "name": [
            "Department of Obstetrics and Gynecology, Hadassah Hebrew-University Medical Center, Ein-Kerem, Jerusalem, 91120, Israel"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Brzezinski", 
        "givenName": "Amnon", 
        "id": "sg:person.01104100667.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104100667.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital Universiti Sains Malaysia", 
          "id": "https://www.grid.ac/institutes/grid.428821.5", 
          "name": [
            "Department of Psychiatry, School of Medical Sciences, Hospital Universiti Sains Malaysia, Kubang Kerian, Kelantan, 16150, Malaysia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Othman", 
        "givenName": "Zahiruddin", 
        "id": "sg:person.01341031556.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01341031556.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Neurology, Dr BL Kapur Superspeciality Hospital, Pusa Road, New Delhi, DL, 110005, India"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Prasad", 
        "givenName": "Atul", 
        "id": "sg:person.016036273246.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016036273246.21"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.sleep.2005.09.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000395461"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.sleep.2008.04.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000829135"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.sleep.2008.04.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000829135"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.sleep.2004.07.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001437775"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1016/0009-9236(95)90040-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001529780", 
          "https://doi.org/10.1016/0009-9236(95)90040-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0149-2918(08)80056-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001913309"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/074873049701200622", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003204806"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/074873049701200622", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003204806"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1034/j.1600-079x.2003.00072.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004839862"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/00207450802328607", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004875692"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1034/j.1600-079x.2001.280309.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005451726"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuroimage.2005.11.024", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006534300"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0896-6273(94)90055-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007737076"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0024-3205(02)01991-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009463342"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0024-3205(02)01991-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009463342"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0167-4943(98)00129-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010434038"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1532-5415.2001.49235.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012055473"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.sleep.2006.01.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013052512"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.38731.532766.f6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013609861"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0896-6273(00)80350-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014431501"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuropharm.2004.09.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015323986"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tins.2004.12.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016147890"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/074873049701200618", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018594461"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/074873049701200618", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018594461"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1185/03007995.2010.537317", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018860743"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0014-2999(97)01443-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020376949"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0091270006298602", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021155753"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1185/030079907x178874", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022295010"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1586/ern.10.197", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024443533"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(95)91382-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027021428"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(95)91382-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027021428"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1186/1740-3391-4-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027265324"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11065-011-9160-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028412874", 
          "https://doi.org/10.1007/s11065-011-9160-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0748730406294627", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028778076"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0748730406294627", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028778076"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.smrv.2004.06.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029448779"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/074873049701200616", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029853277"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/074873049701200616", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029853277"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0269881110379307", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032597735"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0269881110379307", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032597735"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/07420520600651073", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034473150"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12325-010-0065-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034669673", 
          "https://doi.org/10.1007/s12325-010-0065-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12325-010-0065-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034669673", 
          "https://doi.org/10.1007/s12325-010-0065-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1087-0792(03)00026-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035041001"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04284", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038404825", 
          "https://doi.org/10.1038/nature04284"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04284", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038404825", 
          "https://doi.org/10.1038/nature04284"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature04284", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038404825", 
          "https://doi.org/10.1038/nature04284"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.91.5.1824", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042857541"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0531-5565(00)00191-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045736528"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.sleep.2010.10.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045742883"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1586/ern.11.128", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046084433"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cne.21152", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046966951"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1096/fj.03-1339com", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048294978"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1124/pr.110.002832", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048396841"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0149-7634(95)00052-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048467331"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/yic.0b013e3283400d35", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050305974"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/yic.0b013e3283400d35", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050305974"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1755-5949.2008.00066.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052904333"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja01543a060", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055806021"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.2845576", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062565732"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jcem.86.10.7901", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064323871"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1258/mi.2009.009002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064539037"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1258/mi.2009.009002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064539037"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2174/187152712800269740", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1069221718"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4088/jcp.v68n1112", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072210026"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074605869", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076602803", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076999731", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/sleep/28.3.303", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077115806"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077476618", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077738420", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/sleep/32.3.351", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077866875"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082203666", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/sleep/19.5.423", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082973076"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/sleep/20.10.916", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083191616"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2014", 
    "datePublishedReg": "2014-01-01", 
    "description": "The efficacy of melatonin in promoting and maintaining sleep has been demonstrated in most of the clinical studies. However, because of its short half-life, its sustained effect in improving sleep quality could not be demonstrated uniformly in all the studies that have been undertaken so far. The development of slow-release melatonin preparation Circadin has been found effective in reducing sleep onset time and also for improving sleep quality. This was followed by the introduction of another melatonergic drug ramelteon a melatonin receptor agonist that has high selectivity for MT1 receptors than MT2 receptors and therefore targets sleep onset more specifically than melatonin. Clinical trials undertaken in different countries of European region and Japan have conclusively demonstrated that ramelteon in various doses (from 4 to 32 mg/day) reduced sleep onset latency, increased total sleep time, and sleep efficiency and quality in patients suffering from chronic insomnia. Besides acting as a sedative-hypnotic drug, ramelteon also demonstrated its ability as a drug with chronobiotic properties and has been found useful in resetting the disturbed circadian rhythms. The action of ramelteon in improving sleep efficiency is dose independent and hence acts differently from melatonin. It has a promising value in treating patients with chronic insomnia as it does not have any of the adverse effects like next-day hangover and dependence associated with the usage of other conventional hypnotic drugs.", 
    "editor": [
      {
        "familyName": "Srinivasan", 
        "givenName": "V.", 
        "type": "Person"
      }, 
      {
        "familyName": "Brzezinski", 
        "givenName": "Amnon", 
        "type": "Person"
      }, 
      {
        "familyName": "Oter", 
        "givenName": "Sukru", 
        "type": "Person"
      }, 
      {
        "familyName": "Shillcutt", 
        "givenName": "Samuel D.", 
        "type": "Person"
      }
    ], 
    "genre": "chapter", 
    "id": "sg:pub.10.1007/978-81-322-0825-9_24", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": {
      "isbn": [
        "978-81-322-0824-2", 
        "978-81-322-0825-9"
      ], 
      "name": "Melatonin and Melatonergic Drugs in Clinical Practice", 
      "type": "Book"
    }, 
    "name": "Melatonergic Drug: Ramelteon and Its Therapeutic Applications in Insomnia", 
    "pagination": "343-352", 
    "productId": [
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/978-81-322-0825-9_24"
        ]
      }, 
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "3fdd826e4f0a7eb5b7821e5062e8c47ec7bcb9d3f90cbe6ad68b31d8bd857080"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1013406076"
        ]
      }
    ], 
    "publisher": {
      "location": "New Delhi", 
      "name": "Springer India", 
      "type": "Organisation"
    }, 
    "sameAs": [
      "https://doi.org/10.1007/978-81-322-0825-9_24", 
      "https://app.dimensions.ai/details/publication/pub.1013406076"
    ], 
    "sdDataset": "chapters", 
    "sdDatePublished": "2019-04-15T12:30", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8663_00000251.jsonl", 
    "type": "Chapter", 
    "url": "http://link.springer.com/10.1007/978-81-322-0825-9_24"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-81-322-0825-9_24'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-81-322-0825-9_24'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-81-322-0825-9_24'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-81-322-0825-9_24'


 

This table displays all metadata directly associated to this object as RDF triples.

332 TRIPLES      23 PREDICATES      89 URIs      20 LITERALS      8 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/978-81-322-0825-9_24 schema:about anzsrc-for:11
2 anzsrc-for:1115
3 schema:author N48112bd03bb745cfab51cfdab98c9c64
4 schema:citation sg:pub.10.1007/s11065-011-9160-3
5 sg:pub.10.1007/s12325-010-0065-y
6 sg:pub.10.1016/0009-9236(95)90040-3
7 sg:pub.10.1038/nature04284
8 https://app.dimensions.ai/details/publication/pub.1074605869
9 https://app.dimensions.ai/details/publication/pub.1076602803
10 https://app.dimensions.ai/details/publication/pub.1076999731
11 https://app.dimensions.ai/details/publication/pub.1077476618
12 https://app.dimensions.ai/details/publication/pub.1077738420
13 https://app.dimensions.ai/details/publication/pub.1082203666
14 https://doi.org/10.1002/cne.21152
15 https://doi.org/10.1016/0149-7634(95)00052-6
16 https://doi.org/10.1016/0896-6273(94)90055-8
17 https://doi.org/10.1016/j.neuroimage.2005.11.024
18 https://doi.org/10.1016/j.neuropharm.2004.09.007
19 https://doi.org/10.1016/j.sleep.2004.07.009
20 https://doi.org/10.1016/j.sleep.2005.09.004
21 https://doi.org/10.1016/j.sleep.2006.01.003
22 https://doi.org/10.1016/j.sleep.2008.04.010
23 https://doi.org/10.1016/j.sleep.2010.10.006
24 https://doi.org/10.1016/j.smrv.2004.06.004
25 https://doi.org/10.1016/j.tins.2004.12.009
26 https://doi.org/10.1016/s0014-2999(97)01443-x
27 https://doi.org/10.1016/s0024-3205(02)01991-4
28 https://doi.org/10.1016/s0140-6736(95)91382-3
29 https://doi.org/10.1016/s0149-2918(08)80056-2
30 https://doi.org/10.1016/s0167-4943(98)00129-0
31 https://doi.org/10.1016/s0531-5565(00)00191-1
32 https://doi.org/10.1016/s0896-6273(00)80350-5
33 https://doi.org/10.1016/s1087-0792(03)00026-1
34 https://doi.org/10.1021/ja01543a060
35 https://doi.org/10.1034/j.1600-079x.2001.280309.x
36 https://doi.org/10.1034/j.1600-079x.2003.00072.x
37 https://doi.org/10.1046/j.1532-5415.2001.49235.x
38 https://doi.org/10.1073/pnas.91.5.1824
39 https://doi.org/10.1080/00207450802328607
40 https://doi.org/10.1080/07420520600651073
41 https://doi.org/10.1093/sleep/19.5.423
42 https://doi.org/10.1093/sleep/20.10.916
43 https://doi.org/10.1093/sleep/28.3.303
44 https://doi.org/10.1093/sleep/32.3.351
45 https://doi.org/10.1096/fj.03-1339com
46 https://doi.org/10.1097/yic.0b013e3283400d35
47 https://doi.org/10.1111/j.1755-5949.2008.00066.x
48 https://doi.org/10.1124/pr.110.002832
49 https://doi.org/10.1126/science.2845576
50 https://doi.org/10.1136/bmj.38731.532766.f6
51 https://doi.org/10.1177/0091270006298602
52 https://doi.org/10.1177/0269881110379307
53 https://doi.org/10.1177/0748730406294627
54 https://doi.org/10.1177/074873049701200616
55 https://doi.org/10.1177/074873049701200618
56 https://doi.org/10.1177/074873049701200622
57 https://doi.org/10.1185/030079907x178874
58 https://doi.org/10.1185/03007995.2010.537317
59 https://doi.org/10.1186/1740-3391-4-2
60 https://doi.org/10.1210/jcem.86.10.7901
61 https://doi.org/10.1258/mi.2009.009002
62 https://doi.org/10.1586/ern.10.197
63 https://doi.org/10.1586/ern.11.128
64 https://doi.org/10.2174/187152712800269740
65 https://doi.org/10.4088/jcp.v68n1112
66 schema:datePublished 2014
67 schema:datePublishedReg 2014-01-01
68 schema:description The efficacy of melatonin in promoting and maintaining sleep has been demonstrated in most of the clinical studies. However, because of its short half-life, its sustained effect in improving sleep quality could not be demonstrated uniformly in all the studies that have been undertaken so far. The development of slow-release melatonin preparation Circadin has been found effective in reducing sleep onset time and also for improving sleep quality. This was followed by the introduction of another melatonergic drug ramelteon a melatonin receptor agonist that has high selectivity for MT1 receptors than MT2 receptors and therefore targets sleep onset more specifically than melatonin. Clinical trials undertaken in different countries of European region and Japan have conclusively demonstrated that ramelteon in various doses (from 4 to 32 mg/day) reduced sleep onset latency, increased total sleep time, and sleep efficiency and quality in patients suffering from chronic insomnia. Besides acting as a sedative-hypnotic drug, ramelteon also demonstrated its ability as a drug with chronobiotic properties and has been found useful in resetting the disturbed circadian rhythms. The action of ramelteon in improving sleep efficiency is dose independent and hence acts differently from melatonin. It has a promising value in treating patients with chronic insomnia as it does not have any of the adverse effects like next-day hangover and dependence associated with the usage of other conventional hypnotic drugs.
69 schema:editor Ne16e45246c6b4bc0a325060b18f1d6b1
70 schema:genre chapter
71 schema:inLanguage en
72 schema:isAccessibleForFree false
73 schema:isPartOf Nac3b96487611461aa013281ac350f03b
74 schema:name Melatonergic Drug: Ramelteon and Its Therapeutic Applications in Insomnia
75 schema:pagination 343-352
76 schema:productId N1dce2e2e50a24b028d9d677ef5248f8e
77 N48433bdd7feb493298633f7e28773b93
78 Nbda44a96e73f424e887c4c20b167f019
79 schema:publisher Ncad3d65c510a47fc823653957633d224
80 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013406076
81 https://doi.org/10.1007/978-81-322-0825-9_24
82 schema:sdDatePublished 2019-04-15T12:30
83 schema:sdLicense https://scigraph.springernature.com/explorer/license/
84 schema:sdPublisher Nc3c750f5f32c44e5b5a21a8b8bb1013a
85 schema:url http://link.springer.com/10.1007/978-81-322-0825-9_24
86 sgo:license sg:explorer/license/
87 sgo:sdDataset chapters
88 rdf:type schema:Chapter
89 N17e388afd8d948868286e6c271f2ad54 rdf:first N945850c85a444d53aab41aa42393e83c
90 rdf:rest N43f3a132edb64b9ab4062017ca9a610b
91 N1dce2e2e50a24b028d9d677ef5248f8e schema:name dimensions_id
92 schema:value pub.1013406076
93 rdf:type schema:PropertyValue
94 N26a5c7525e3d4a0a8e3c0aec45de0697 schema:familyName Shillcutt
95 schema:givenName Samuel D.
96 rdf:type schema:Person
97 N2a523dffdd854a93aa6d8b5071af9d98 schema:familyName Oter
98 schema:givenName Sukru
99 rdf:type schema:Person
100 N3aabcd400d264f098945fad2e9722252 rdf:first sg:person.01104100667.80
101 rdf:rest Ncef1977281714b47b5f9420a58546f36
102 N43f3a132edb64b9ab4062017ca9a610b rdf:first N2a523dffdd854a93aa6d8b5071af9d98
103 rdf:rest N7df7ee67ece54b7ab7163244c2d8e80c
104 N48112bd03bb745cfab51cfdab98c9c64 rdf:first sg:person.01237721775.15
105 rdf:rest Na911b3de44b04067961af02378e47861
106 N48433bdd7feb493298633f7e28773b93 schema:name doi
107 schema:value 10.1007/978-81-322-0825-9_24
108 rdf:type schema:PropertyValue
109 N5b703e4454b84e4c823c69c9edf4ab0c rdf:first sg:person.016036273246.21
110 rdf:rest rdf:nil
111 N7df7ee67ece54b7ab7163244c2d8e80c rdf:first N26a5c7525e3d4a0a8e3c0aec45de0697
112 rdf:rest rdf:nil
113 N89a7423ebf9b4e009777ccb77a731222 schema:name Sri Sathya Sai Medical Educational and Research Foundation, An International Medical Sciences Research Study Center, Prasanthi Nilayam, 40-Kovai Thirunagar Extn, Goldwins, Coimbatore, TN, 641014, India
114 rdf:type schema:Organization
115 N945850c85a444d53aab41aa42393e83c schema:familyName Brzezinski
116 schema:givenName Amnon
117 rdf:type schema:Person
118 Na911b3de44b04067961af02378e47861 rdf:first sg:person.01224603156.65
119 rdf:rest Neb18ad25540e4a6687925c03b9bd80c2
120 Nac3b96487611461aa013281ac350f03b schema:isbn 978-81-322-0824-2
121 978-81-322-0825-9
122 schema:name Melatonin and Melatonergic Drugs in Clinical Practice
123 rdf:type schema:Book
124 Nbda44a96e73f424e887c4c20b167f019 schema:name readcube_id
125 schema:value 3fdd826e4f0a7eb5b7821e5062e8c47ec7bcb9d3f90cbe6ad68b31d8bd857080
126 rdf:type schema:PropertyValue
127 Nc3c750f5f32c44e5b5a21a8b8bb1013a schema:name Springer Nature - SN SciGraph project
128 rdf:type schema:Organization
129 Ncad3d65c510a47fc823653957633d224 schema:location New Delhi
130 schema:name Springer India
131 rdf:type schema:Organisation
132 Ncef1977281714b47b5f9420a58546f36 rdf:first sg:person.01341031556.31
133 rdf:rest N5b703e4454b84e4c823c69c9edf4ab0c
134 Ne16e45246c6b4bc0a325060b18f1d6b1 rdf:first Nf69e1dee62b449eeaac566132081f8a0
135 rdf:rest N17e388afd8d948868286e6c271f2ad54
136 Neb18ad25540e4a6687925c03b9bd80c2 rdf:first sg:person.01112354114.74
137 rdf:rest Nf02ec39d195e4622980e766f55d71d5a
138 Nf02ec39d195e4622980e766f55d71d5a rdf:first sg:person.0632502703.19
139 rdf:rest Nfabab49f6732483ea38b4b6344b238e6
140 Nf69e1dee62b449eeaac566132081f8a0 schema:familyName Srinivasan
141 schema:givenName V.
142 rdf:type schema:Person
143 Nf900e86970e5473dae433fcfc3e3edcd schema:name Department of Neurology, Dr BL Kapur Superspeciality Hospital, Pusa Road, New Delhi, DL, 110005, India
144 rdf:type schema:Organization
145 Nfabab49f6732483ea38b4b6344b238e6 rdf:first sg:person.0735115013.12
146 rdf:rest N3aabcd400d264f098945fad2e9722252
147 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
148 schema:name Medical and Health Sciences
149 rdf:type schema:DefinedTerm
150 anzsrc-for:1115 schema:inDefinedTermSet anzsrc-for:
151 schema:name Pharmacology and Pharmaceutical Sciences
152 rdf:type schema:DefinedTerm
153 sg:person.01104100667.80 schema:affiliation https://www.grid.ac/institutes/grid.17788.31
154 schema:familyName Brzezinski
155 schema:givenName Amnon
156 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104100667.80
157 rdf:type schema:Person
158 sg:person.01112354114.74 schema:affiliation https://www.grid.ac/institutes/grid.14758.3f
159 schema:familyName Partonen
160 schema:givenName Timo
161 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01112354114.74
162 rdf:type schema:Person
163 sg:person.01224603156.65 schema:affiliation https://www.grid.ac/institutes/grid.11875.3a
164 schema:familyName Zakaria
165 schema:givenName Rahimah
166 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224603156.65
167 rdf:type schema:Person
168 sg:person.01237721775.15 schema:affiliation N89a7423ebf9b4e009777ccb77a731222
169 schema:familyName Srinivasan
170 schema:givenName Venkataramanujam
171 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01237721775.15
172 rdf:type schema:Person
173 sg:person.01341031556.31 schema:affiliation https://www.grid.ac/institutes/grid.428821.5
174 schema:familyName Othman
175 schema:givenName Zahiruddin
176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01341031556.31
177 rdf:type schema:Person
178 sg:person.016036273246.21 schema:affiliation Nf900e86970e5473dae433fcfc3e3edcd
179 schema:familyName Prasad
180 schema:givenName Atul
181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016036273246.21
182 rdf:type schema:Person
183 sg:person.0632502703.19 schema:affiliation https://www.grid.ac/institutes/grid.259906.1
184 schema:familyName Lauterbach
185 schema:givenName Edward C.
186 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0632502703.19
187 rdf:type schema:Person
188 sg:person.0735115013.12 schema:affiliation https://www.grid.ac/institutes/grid.66875.3a
189 schema:familyName Kuppuswamy
190 schema:givenName Preetha Sharone
191 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0735115013.12
192 rdf:type schema:Person
193 sg:pub.10.1007/s11065-011-9160-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028412874
194 https://doi.org/10.1007/s11065-011-9160-3
195 rdf:type schema:CreativeWork
196 sg:pub.10.1007/s12325-010-0065-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1034669673
197 https://doi.org/10.1007/s12325-010-0065-y
198 rdf:type schema:CreativeWork
199 sg:pub.10.1016/0009-9236(95)90040-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001529780
200 https://doi.org/10.1016/0009-9236(95)90040-3
201 rdf:type schema:CreativeWork
202 sg:pub.10.1038/nature04284 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038404825
203 https://doi.org/10.1038/nature04284
204 rdf:type schema:CreativeWork
205 https://app.dimensions.ai/details/publication/pub.1074605869 schema:CreativeWork
206 https://app.dimensions.ai/details/publication/pub.1076602803 schema:CreativeWork
207 https://app.dimensions.ai/details/publication/pub.1076999731 schema:CreativeWork
208 https://app.dimensions.ai/details/publication/pub.1077476618 schema:CreativeWork
209 https://app.dimensions.ai/details/publication/pub.1077738420 schema:CreativeWork
210 https://app.dimensions.ai/details/publication/pub.1082203666 schema:CreativeWork
211 https://doi.org/10.1002/cne.21152 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046966951
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1016/0149-7634(95)00052-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048467331
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1016/0896-6273(94)90055-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007737076
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1016/j.neuroimage.2005.11.024 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006534300
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1016/j.neuropharm.2004.09.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015323986
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1016/j.sleep.2004.07.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001437775
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1016/j.sleep.2005.09.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000395461
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1016/j.sleep.2006.01.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013052512
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1016/j.sleep.2008.04.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000829135
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1016/j.sleep.2010.10.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045742883
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1016/j.smrv.2004.06.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029448779
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1016/j.tins.2004.12.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016147890
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1016/s0014-2999(97)01443-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1020376949
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1016/s0024-3205(02)01991-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009463342
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1016/s0140-6736(95)91382-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027021428
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1016/s0149-2918(08)80056-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001913309
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1016/s0167-4943(98)00129-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010434038
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1016/s0531-5565(00)00191-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045736528
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1016/s0896-6273(00)80350-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014431501
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1016/s1087-0792(03)00026-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035041001
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1021/ja01543a060 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055806021
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1034/j.1600-079x.2001.280309.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1005451726
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1034/j.1600-079x.2003.00072.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1004839862
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1046/j.1532-5415.2001.49235.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1012055473
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1073/pnas.91.5.1824 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042857541
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1080/00207450802328607 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004875692
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1080/07420520600651073 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034473150
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1093/sleep/19.5.423 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082973076
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1093/sleep/20.10.916 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083191616
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1093/sleep/28.3.303 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077115806
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1093/sleep/32.3.351 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077866875
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1096/fj.03-1339com schema:sameAs https://app.dimensions.ai/details/publication/pub.1048294978
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1097/yic.0b013e3283400d35 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050305974
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1111/j.1755-5949.2008.00066.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1052904333
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1124/pr.110.002832 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048396841
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1126/science.2845576 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062565732
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1136/bmj.38731.532766.f6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013609861
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1177/0091270006298602 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021155753
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1177/0269881110379307 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032597735
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1177/0748730406294627 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028778076
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1177/074873049701200616 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029853277
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1177/074873049701200618 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018594461
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1177/074873049701200622 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003204806
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1185/030079907x178874 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022295010
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1185/03007995.2010.537317 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018860743
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1186/1740-3391-4-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027265324
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1210/jcem.86.10.7901 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064323871
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1258/mi.2009.009002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064539037
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1586/ern.10.197 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024443533
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1586/ern.11.128 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046084433
310 rdf:type schema:CreativeWork
311 https://doi.org/10.2174/187152712800269740 schema:sameAs https://app.dimensions.ai/details/publication/pub.1069221718
312 rdf:type schema:CreativeWork
313 https://doi.org/10.4088/jcp.v68n1112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072210026
314 rdf:type schema:CreativeWork
315 https://www.grid.ac/institutes/grid.11875.3a schema:alternateName Universiti Sains Malaysia
316 schema:name Department of Physiology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, 16150, Malaysia
317 rdf:type schema:Organization
318 https://www.grid.ac/institutes/grid.14758.3f schema:alternateName National Institute for Health and Welfare
319 schema:name Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Mannerheimintie 166, FI-00300 Helsinki, Finland
320 rdf:type schema:Organization
321 https://www.grid.ac/institutes/grid.17788.31 schema:alternateName Hadassah Medical Center
322 schema:name Department of Obstetrics and Gynecology, Hadassah Hebrew-University Medical Center, Ein-Kerem, Jerusalem, 91120, Israel
323 rdf:type schema:Organization
324 https://www.grid.ac/institutes/grid.259906.1 schema:alternateName Mercer University
325 schema:name Department of Psychiatry and Behavioral Sciences, and the Department of Internal Medicine, Neurology Section, Mercer University School of Medicine, 655 First Street, Macon, GA 31201, USA
326 rdf:type schema:Organization
327 https://www.grid.ac/institutes/grid.428821.5 schema:alternateName Hospital Universiti Sains Malaysia
328 schema:name Department of Psychiatry, School of Medical Sciences, Hospital Universiti Sains Malaysia, Kubang Kerian, Kelantan, 16150, Malaysia
329 rdf:type schema:Organization
330 https://www.grid.ac/institutes/grid.66875.3a schema:alternateName Mayo Clinic
331 schema:name Department of Psychiatry and Psychology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
332 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...