Underlying Morphological Changes in the Arterial Wall at Bifurcations for Atherogenesis View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1988

AUTHORS

Y. Yoshida , T. Oyama , S. Wang , T. Yamane , M. Mitsumata , T. Yamaguchi , G. Ooneda

ABSTRACT

Apical and outer wall intimas at branchings of inferior mesenteric arteries from aortas of human autopsy cases were investigated. The outer wall intima, a low shear stress region, was thicker than the apical intima, a high shear stress region, except in cases younger than one month. Deposit of ß-lipoproteins in the outer wall intima increased with age, but not that in the apical intima. Electron microscopic studies revealed that collagen fibers increased markedly in the apical intima in the third decade. Among the dense collagen fibers, intimai smooth muscle cells(SMC) exhibited contractile phenotype. The outer wall possessed mucinous intima accompanied with synthetic SMC. Atherosclerotic rabbit intimai SMC cultivated on type 1 collagen gel increased cAMP production to change phenotype from synthetic to contractile and to suppress DNA synthesis. Early lipid deposition of rabbits placed on an atherogenic diet within three weeks occurred in special linear areas of flow dividers. As a result, blood flow dynamics may induce cellular and microarchitectural changes in vessel walls which are favorable or resistant to atherogenesis. More... »

PAGES

33-40

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-4-431-68399-5_5

DOI

http://dx.doi.org/10.1007/978-4-431-68399-5_5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1021513536


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Pathology, Yamanashi Medical College, 409-38, Tamaho, Japan", 
          "id": "http://www.grid.ac/institutes/grid.267500.6", 
          "name": [
            "Department of Pathology, Yamanashi Medical College, 409-38, Tamaho, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yoshida", 
        "givenName": "Y.", 
        "id": "sg:person.0111607231.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0111607231.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, Yamanashi Medical College, 409-38, Tamaho, Japan", 
          "id": "http://www.grid.ac/institutes/grid.267500.6", 
          "name": [
            "Department of Pathology, Yamanashi Medical College, 409-38, Tamaho, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Oyama", 
        "givenName": "T.", 
        "id": "sg:person.011405362052.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011405362052.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, Yamanashi Medical College, 409-38, Tamaho, Japan", 
          "id": "http://www.grid.ac/institutes/grid.267500.6", 
          "name": [
            "Department of Pathology, Yamanashi Medical College, 409-38, Tamaho, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "S.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, Yamanashi Medical College, 409-38, Tamaho, Japan", 
          "id": "http://www.grid.ac/institutes/grid.267500.6", 
          "name": [
            "Department of Pathology, Yamanashi Medical College, 409-38, Tamaho, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yamane", 
        "givenName": "T.", 
        "id": "sg:person.0760475461.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760475461.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, Yamanashi Medical College, 409-38, Tamaho, Japan", 
          "id": "http://www.grid.ac/institutes/grid.267500.6", 
          "name": [
            "Department of Pathology, Yamanashi Medical College, 409-38, Tamaho, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mitsumata", 
        "givenName": "M.", 
        "id": "sg:person.0620710407.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620710407.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Vascular Physiology, National Cardiovascular Center Research Institute, Suita, 565, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410796.d", 
          "name": [
            "Department of Vascular Physiology, National Cardiovascular Center Research Institute, Suita, 565, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yamaguchi", 
        "givenName": "T.", 
        "id": "sg:person.013377607575.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013377607575.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Geriatrics Research Institute and Hospital, Maebashi, 371, Japan", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Geriatrics Research Institute and Hospital, Maebashi, 371, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ooneda", 
        "givenName": "G.", 
        "id": "sg:person.053317326.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.053317326.51"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "1988", 
    "datePublishedReg": "1988-01-01", 
    "description": "Apical and outer wall intimas at branchings of inferior mesenteric arteries from aortas of human autopsy cases were investigated. The outer wall intima, a low shear stress region, was thicker than the apical intima, a high shear stress region, except in cases younger than one month. Deposit of \u00df-lipoproteins in the outer wall intima increased with age, but not that in the apical intima. Electron microscopic studies revealed that collagen fibers increased markedly in the apical intima in the third decade. Among the dense collagen fibers, intimai smooth muscle cells(SMC) exhibited contractile phenotype. The outer wall possessed mucinous intima accompanied with synthetic SMC. Atherosclerotic rabbit intimai SMC cultivated on type 1 collagen gel increased cAMP production to change phenotype from synthetic to contractile and to suppress DNA synthesis. Early lipid deposition of rabbits placed on an atherogenic diet within three weeks occurred in special linear areas of flow dividers. As a result, blood flow dynamics may induce cellular and microarchitectural changes in vessel walls which are favorable or resistant to atherogenesis.", 
    "editor": [
      {
        "familyName": "Yoshida", 
        "givenName": "Yoji", 
        "type": "Person"
      }, 
      {
        "familyName": "Yamaguchi", 
        "givenName": "Takami", 
        "type": "Person"
      }, 
      {
        "familyName": "Caro", 
        "givenName": "Colin G.", 
        "type": "Person"
      }, 
      {
        "familyName": "Glagov", 
        "givenName": "Seymour", 
        "type": "Person"
      }, 
      {
        "familyName": "Nerem", 
        "givenName": "Robert M.", 
        "type": "Person"
      }
    ], 
    "genre": "chapter", 
    "id": "sg:pub.10.1007/978-4-431-68399-5_5", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": {
      "isbn": [
        "978-4-431-68401-5", 
        "978-4-431-68399-5"
      ], 
      "name": "Role of Blood Flow in Atherogenesis", 
      "type": "Book"
    }, 
    "keywords": [
      "inferior mesenteric artery", 
      "early lipid deposition", 
      "human autopsy cases", 
      "dense collagen fibers", 
      "mesenteric artery", 
      "collagen fibers", 
      "atherogenic diet", 
      "autopsy cases", 
      "type 1 collagen gel", 
      "smooth muscle", 
      "lipid deposition", 
      "third decade", 
      "cAMP production", 
      "intima", 
      "blood flow dynamics", 
      "microarchitectural changes", 
      "arterial wall", 
      "electron microscopic study", 
      "contractile phenotype", 
      "synthetic SMCs", 
      "vessel wall", 
      "atherogenesis", 
      "microscopic study", 
      "DNA synthesis", 
      "morphological changes", 
      "collagen gels", 
      "linear area", 
      "flow divider", 
      "phenotype", 
      "artery", 
      "aorta", 
      "lipoproteins", 
      "weeks", 
      "months", 
      "muscle", 
      "rabbits", 
      "age", 
      "diet", 
      "cases", 
      "wall", 
      "changes", 
      "shear stress regions", 
      "low shear stress regions", 
      "fibers", 
      "study", 
      "SMC", 
      "region", 
      "production", 
      "decades", 
      "area", 
      "results", 
      "flow dynamics", 
      "branching", 
      "gel", 
      "bifurcation", 
      "synthesis", 
      "outer wall", 
      "deposition", 
      "synthetic", 
      "deposits", 
      "stress region", 
      "high shear stress regions", 
      "dynamics", 
      "divider", 
      "outer wall intima", 
      "wall intima", 
      "apical intima", 
      "intimai smooth muscle", 
      "mucinous intima", 
      "Atherosclerotic rabbit intimai SMC", 
      "rabbit intimai SMC", 
      "intimai SMC", 
      "special linear areas"
    ], 
    "name": "Underlying Morphological Changes in the Arterial Wall at Bifurcations for Atherogenesis", 
    "pagination": "33-40", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1021513536"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/978-4-431-68399-5_5"
        ]
      }
    ], 
    "publisher": {
      "name": "Springer Nature", 
      "type": "Organisation"
    }, 
    "sameAs": [
      "https://doi.org/10.1007/978-4-431-68399-5_5", 
      "https://app.dimensions.ai/details/publication/pub.1021513536"
    ], 
    "sdDataset": "chapters", 
    "sdDatePublished": "2022-01-01T19:21", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/chapter/chapter_363.jsonl", 
    "type": "Chapter", 
    "url": "https://doi.org/10.1007/978-4-431-68399-5_5"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-4-431-68399-5_5'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-4-431-68399-5_5'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-4-431-68399-5_5'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-4-431-68399-5_5'


 

This table displays all metadata directly associated to this object as RDF triples.

200 TRIPLES      23 PREDICATES      99 URIs      92 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/978-4-431-68399-5_5 schema:about anzsrc-for:11
2 anzsrc-for:1102
3 schema:author N3f9d33f7c2404e0a98eb7d3eae9fa0a7
4 schema:datePublished 1988
5 schema:datePublishedReg 1988-01-01
6 schema:description Apical and outer wall intimas at branchings of inferior mesenteric arteries from aortas of human autopsy cases were investigated. The outer wall intima, a low shear stress region, was thicker than the apical intima, a high shear stress region, except in cases younger than one month. Deposit of ß-lipoproteins in the outer wall intima increased with age, but not that in the apical intima. Electron microscopic studies revealed that collagen fibers increased markedly in the apical intima in the third decade. Among the dense collagen fibers, intimai smooth muscle cells(SMC) exhibited contractile phenotype. The outer wall possessed mucinous intima accompanied with synthetic SMC. Atherosclerotic rabbit intimai SMC cultivated on type 1 collagen gel increased cAMP production to change phenotype from synthetic to contractile and to suppress DNA synthesis. Early lipid deposition of rabbits placed on an atherogenic diet within three weeks occurred in special linear areas of flow dividers. As a result, blood flow dynamics may induce cellular and microarchitectural changes in vessel walls which are favorable or resistant to atherogenesis.
7 schema:editor N9f5aa907efe64e0ab25ead70267abb8b
8 schema:genre chapter
9 schema:inLanguage en
10 schema:isAccessibleForFree false
11 schema:isPartOf Nf7376e7689464a2c945f135e23fc0aa6
12 schema:keywords Atherosclerotic rabbit intimai SMC
13 DNA synthesis
14 SMC
15 age
16 aorta
17 apical intima
18 area
19 arterial wall
20 artery
21 atherogenesis
22 atherogenic diet
23 autopsy cases
24 bifurcation
25 blood flow dynamics
26 branching
27 cAMP production
28 cases
29 changes
30 collagen fibers
31 collagen gels
32 contractile phenotype
33 decades
34 dense collagen fibers
35 deposition
36 deposits
37 diet
38 divider
39 dynamics
40 early lipid deposition
41 electron microscopic study
42 fibers
43 flow divider
44 flow dynamics
45 gel
46 high shear stress regions
47 human autopsy cases
48 inferior mesenteric artery
49 intima
50 intimai SMC
51 intimai smooth muscle
52 linear area
53 lipid deposition
54 lipoproteins
55 low shear stress regions
56 mesenteric artery
57 microarchitectural changes
58 microscopic study
59 months
60 morphological changes
61 mucinous intima
62 muscle
63 outer wall
64 outer wall intima
65 phenotype
66 production
67 rabbit intimai SMC
68 rabbits
69 region
70 results
71 shear stress regions
72 smooth muscle
73 special linear areas
74 stress region
75 study
76 synthesis
77 synthetic
78 synthetic SMCs
79 third decade
80 type 1 collagen gel
81 vessel wall
82 wall
83 wall intima
84 weeks
85 schema:name Underlying Morphological Changes in the Arterial Wall at Bifurcations for Atherogenesis
86 schema:pagination 33-40
87 schema:productId N34cfd2a84a15447a9936e35e9586f70a
88 N943a9a543b73442c9276666f2be221fd
89 schema:publisher N7dccd8cdb16e4aa7a603f2d818427d62
90 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021513536
91 https://doi.org/10.1007/978-4-431-68399-5_5
92 schema:sdDatePublished 2022-01-01T19:21
93 schema:sdLicense https://scigraph.springernature.com/explorer/license/
94 schema:sdPublisher N62a659c4c2ea43dcb945925373150b45
95 schema:url https://doi.org/10.1007/978-4-431-68399-5_5
96 sgo:license sg:explorer/license/
97 sgo:sdDataset chapters
98 rdf:type schema:Chapter
99 N17f42e98a8d74a81b9c9bc06be695da2 schema:familyName Yamaguchi
100 schema:givenName Takami
101 rdf:type schema:Person
102 N25ba4cdf12ce4e89899b8f2c78643c5c rdf:first sg:person.0620710407.48
103 rdf:rest Nf2a7443b5a804d9582e3cf6ae90c0ec6
104 N27ba82457a1b4318965711789d491df0 rdf:first sg:person.0760475461.05
105 rdf:rest N25ba4cdf12ce4e89899b8f2c78643c5c
106 N298e145ff1e24086b7b51eab4ba71cb1 schema:familyName Yoshida
107 schema:givenName Yoji
108 rdf:type schema:Person
109 N34cfd2a84a15447a9936e35e9586f70a schema:name doi
110 schema:value 10.1007/978-4-431-68399-5_5
111 rdf:type schema:PropertyValue
112 N3f8a17e3f28e4109b0e7143a74c5e726 rdf:first Ndaabc63dc7274b40a2893be1376931bd
113 rdf:rest N6d899ea4d82849d1bacb20575cd9d04f
114 N3f9d33f7c2404e0a98eb7d3eae9fa0a7 rdf:first sg:person.0111607231.02
115 rdf:rest Nacefd0adeab0435ca6724bbcd4635f3c
116 N43e64548624f49629c9116a6c042f9d7 schema:affiliation grid-institutes:grid.267500.6
117 schema:familyName Wang
118 schema:givenName S.
119 rdf:type schema:Person
120 N45b9d9a130334caca5d9d9573e35f27f schema:familyName Glagov
121 schema:givenName Seymour
122 rdf:type schema:Person
123 N62a659c4c2ea43dcb945925373150b45 schema:name Springer Nature - SN SciGraph project
124 rdf:type schema:Organization
125 N6d899ea4d82849d1bacb20575cd9d04f rdf:first N45b9d9a130334caca5d9d9573e35f27f
126 rdf:rest N87d13dff42c844e0bd7df04ca5bd8277
127 N6e90488fdcb34b5396ef1db0523186a9 schema:familyName Nerem
128 schema:givenName Robert M.
129 rdf:type schema:Person
130 N7dccd8cdb16e4aa7a603f2d818427d62 schema:name Springer Nature
131 rdf:type schema:Organisation
132 N87d13dff42c844e0bd7df04ca5bd8277 rdf:first N6e90488fdcb34b5396ef1db0523186a9
133 rdf:rest rdf:nil
134 N943a9a543b73442c9276666f2be221fd schema:name dimensions_id
135 schema:value pub.1021513536
136 rdf:type schema:PropertyValue
137 N9a4ab3babcb84408acfb27f7b97a04ce rdf:first N43e64548624f49629c9116a6c042f9d7
138 rdf:rest N27ba82457a1b4318965711789d491df0
139 N9f5aa907efe64e0ab25ead70267abb8b rdf:first N298e145ff1e24086b7b51eab4ba71cb1
140 rdf:rest N9fbcbbe1919b4cd3a31ff8e9a8a28914
141 N9fbcbbe1919b4cd3a31ff8e9a8a28914 rdf:first N17f42e98a8d74a81b9c9bc06be695da2
142 rdf:rest N3f8a17e3f28e4109b0e7143a74c5e726
143 Nacefd0adeab0435ca6724bbcd4635f3c rdf:first sg:person.011405362052.18
144 rdf:rest N9a4ab3babcb84408acfb27f7b97a04ce
145 Ndaabc63dc7274b40a2893be1376931bd schema:familyName Caro
146 schema:givenName Colin G.
147 rdf:type schema:Person
148 Ne61237381ebb4e5f96ead7eb26f235d2 rdf:first sg:person.053317326.51
149 rdf:rest rdf:nil
150 Nf2a7443b5a804d9582e3cf6ae90c0ec6 rdf:first sg:person.013377607575.22
151 rdf:rest Ne61237381ebb4e5f96ead7eb26f235d2
152 Nf7376e7689464a2c945f135e23fc0aa6 schema:isbn 978-4-431-68399-5
153 978-4-431-68401-5
154 schema:name Role of Blood Flow in Atherogenesis
155 rdf:type schema:Book
156 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
157 schema:name Medical and Health Sciences
158 rdf:type schema:DefinedTerm
159 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
160 schema:name Cardiorespiratory Medicine and Haematology
161 rdf:type schema:DefinedTerm
162 sg:person.0111607231.02 schema:affiliation grid-institutes:grid.267500.6
163 schema:familyName Yoshida
164 schema:givenName Y.
165 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0111607231.02
166 rdf:type schema:Person
167 sg:person.011405362052.18 schema:affiliation grid-institutes:grid.267500.6
168 schema:familyName Oyama
169 schema:givenName T.
170 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011405362052.18
171 rdf:type schema:Person
172 sg:person.013377607575.22 schema:affiliation grid-institutes:grid.410796.d
173 schema:familyName Yamaguchi
174 schema:givenName T.
175 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013377607575.22
176 rdf:type schema:Person
177 sg:person.053317326.51 schema:affiliation grid-institutes:None
178 schema:familyName Ooneda
179 schema:givenName G.
180 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.053317326.51
181 rdf:type schema:Person
182 sg:person.0620710407.48 schema:affiliation grid-institutes:grid.267500.6
183 schema:familyName Mitsumata
184 schema:givenName M.
185 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620710407.48
186 rdf:type schema:Person
187 sg:person.0760475461.05 schema:affiliation grid-institutes:grid.267500.6
188 schema:familyName Yamane
189 schema:givenName T.
190 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760475461.05
191 rdf:type schema:Person
192 grid-institutes:None schema:alternateName Geriatrics Research Institute and Hospital, Maebashi, 371, Japan
193 schema:name Geriatrics Research Institute and Hospital, Maebashi, 371, Japan
194 rdf:type schema:Organization
195 grid-institutes:grid.267500.6 schema:alternateName Department of Pathology, Yamanashi Medical College, 409-38, Tamaho, Japan
196 schema:name Department of Pathology, Yamanashi Medical College, 409-38, Tamaho, Japan
197 rdf:type schema:Organization
198 grid-institutes:grid.410796.d schema:alternateName Department of Vascular Physiology, National Cardiovascular Center Research Institute, Suita, 565, Japan
199 schema:name Department of Vascular Physiology, National Cardiovascular Center Research Institute, Suita, 565, Japan
200 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...