Underlying Morphological Changes in the Arterial Wall at Bifurcations for Atherogenesis View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1988

AUTHORS

Y. Yoshida , T. Oyama , S. Wang , T. Yamane , M. Mitsumata , T. Yamaguchi , G. Ooneda

ABSTRACT

Apical and outer wall intimas at branchings of inferior mesenteric arteries from aortas of human autopsy cases were investigated. The outer wall intima, a low shear stress region, was thicker than the apical intima, a high shear stress region, except in cases younger than one month. Deposit of ß-lipoproteins in the outer wall intima increased with age, but not that in the apical intima. Electron microscopic studies revealed that collagen fibers increased markedly in the apical intima in the third decade. Among the dense collagen fibers, intimai smooth muscle cells(SMC) exhibited contractile phenotype. The outer wall possessed mucinous intima accompanied with synthetic SMC. Atherosclerotic rabbit intimai SMC cultivated on type 1 collagen gel increased cAMP production to change phenotype from synthetic to contractile and to suppress DNA synthesis. Early lipid deposition of rabbits placed on an atherogenic diet within three weeks occurred in special linear areas of flow dividers. As a result, blood flow dynamics may induce cellular and microarchitectural changes in vessel walls which are favorable or resistant to atherogenesis. More... »

PAGES

33-40

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-4-431-68399-5_5

DOI

http://dx.doi.org/10.1007/978-4-431-68399-5_5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1021513536


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1102", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Cardiorespiratory Medicine and Haematology", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Pathology, Yamanashi Medical College, 409-38, Tamaho, Japan", 
          "id": "http://www.grid.ac/institutes/grid.267500.6", 
          "name": [
            "Department of Pathology, Yamanashi Medical College, 409-38, Tamaho, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yoshida", 
        "givenName": "Y.", 
        "id": "sg:person.0111607231.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0111607231.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, Yamanashi Medical College, 409-38, Tamaho, Japan", 
          "id": "http://www.grid.ac/institutes/grid.267500.6", 
          "name": [
            "Department of Pathology, Yamanashi Medical College, 409-38, Tamaho, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Oyama", 
        "givenName": "T.", 
        "id": "sg:person.011405362052.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011405362052.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, Yamanashi Medical College, 409-38, Tamaho, Japan", 
          "id": "http://www.grid.ac/institutes/grid.267500.6", 
          "name": [
            "Department of Pathology, Yamanashi Medical College, 409-38, Tamaho, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "S.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, Yamanashi Medical College, 409-38, Tamaho, Japan", 
          "id": "http://www.grid.ac/institutes/grid.267500.6", 
          "name": [
            "Department of Pathology, Yamanashi Medical College, 409-38, Tamaho, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yamane", 
        "givenName": "T.", 
        "id": "sg:person.0760475461.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760475461.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pathology, Yamanashi Medical College, 409-38, Tamaho, Japan", 
          "id": "http://www.grid.ac/institutes/grid.267500.6", 
          "name": [
            "Department of Pathology, Yamanashi Medical College, 409-38, Tamaho, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mitsumata", 
        "givenName": "M.", 
        "id": "sg:person.0620710407.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620710407.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Vascular Physiology, National Cardiovascular Center Research Institute, Suita, 565, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410796.d", 
          "name": [
            "Department of Vascular Physiology, National Cardiovascular Center Research Institute, Suita, 565, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yamaguchi", 
        "givenName": "T.", 
        "id": "sg:person.013377607575.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013377607575.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Geriatrics Research Institute and Hospital, Maebashi, 371, Japan", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Geriatrics Research Institute and Hospital, Maebashi, 371, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ooneda", 
        "givenName": "G.", 
        "id": "sg:person.053317326.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.053317326.51"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "1988", 
    "datePublishedReg": "1988-01-01", 
    "description": "Apical and outer wall intimas at branchings of inferior mesenteric arteries from aortas of human autopsy cases were investigated. The outer wall intima, a low shear stress region, was thicker than the apical intima, a high shear stress region, except in cases younger than one month. Deposit of \u00df-lipoproteins in the outer wall intima increased with age, but not that in the apical intima. Electron microscopic studies revealed that collagen fibers increased markedly in the apical intima in the third decade. Among the dense collagen fibers, intimai smooth muscle cells(SMC) exhibited contractile phenotype. The outer wall possessed mucinous intima accompanied with synthetic SMC. Atherosclerotic rabbit intimai SMC cultivated on type 1 collagen gel increased cAMP production to change phenotype from synthetic to contractile and to suppress DNA synthesis. Early lipid deposition of rabbits placed on an atherogenic diet within three weeks occurred in special linear areas of flow dividers. As a result, blood flow dynamics may induce cellular and microarchitectural changes in vessel walls which are favorable or resistant to atherogenesis.", 
    "editor": [
      {
        "familyName": "Yoshida", 
        "givenName": "Yoji", 
        "type": "Person"
      }, 
      {
        "familyName": "Yamaguchi", 
        "givenName": "Takami", 
        "type": "Person"
      }, 
      {
        "familyName": "Caro", 
        "givenName": "Colin G.", 
        "type": "Person"
      }, 
      {
        "familyName": "Glagov", 
        "givenName": "Seymour", 
        "type": "Person"
      }, 
      {
        "familyName": "Nerem", 
        "givenName": "Robert M.", 
        "type": "Person"
      }
    ], 
    "genre": "chapter", 
    "id": "sg:pub.10.1007/978-4-431-68399-5_5", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": {
      "isbn": [
        "978-4-431-68401-5", 
        "978-4-431-68399-5"
      ], 
      "name": "Role of Blood Flow in Atherogenesis", 
      "type": "Book"
    }, 
    "keywords": [
      "inferior mesenteric artery", 
      "human autopsy cases", 
      "early lipid deposition", 
      "dense collagen fibers", 
      "type 1 collagen gel", 
      "mesenteric artery", 
      "collagen fibers", 
      "atherogenic diet", 
      "autopsy cases", 
      "smooth muscle", 
      "lipid deposition", 
      "intima", 
      "cAMP production", 
      "electron microscopic study", 
      "third decade", 
      "contractile phenotype", 
      "microarchitectural changes", 
      "arterial wall", 
      "blood flow dynamics", 
      "vessel wall", 
      "atherogenesis", 
      "microscopic study", 
      "DNA synthesis", 
      "morphological changes", 
      "synthetic SMCs", 
      "phenotype", 
      "collagen gels", 
      "linear area", 
      "flow divider", 
      "artery", 
      "aorta", 
      "lipoproteins", 
      "months", 
      "weeks", 
      "muscle", 
      "low shear stress regions", 
      "age", 
      "rabbits", 
      "diet", 
      "cases", 
      "changes", 
      "wall", 
      "shear stress regions", 
      "study", 
      "fibers", 
      "SMC", 
      "region", 
      "decades", 
      "production", 
      "area", 
      "results", 
      "branching", 
      "high shear stress regions", 
      "flow dynamics", 
      "gel", 
      "synthesis", 
      "bifurcation", 
      "deposition", 
      "outer wall", 
      "synthetic", 
      "deposits", 
      "stress region", 
      "dynamics", 
      "divider"
    ], 
    "name": "Underlying Morphological Changes in the Arterial Wall at Bifurcations for Atherogenesis", 
    "pagination": "33-40", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1021513536"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/978-4-431-68399-5_5"
        ]
      }
    ], 
    "publisher": {
      "name": "Springer Nature", 
      "type": "Organisation"
    }, 
    "sameAs": [
      "https://doi.org/10.1007/978-4-431-68399-5_5", 
      "https://app.dimensions.ai/details/publication/pub.1021513536"
    ], 
    "sdDataset": "chapters", 
    "sdDatePublished": "2022-05-20T07:44", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220519/entities/gbq_results/chapter/chapter_231.jsonl", 
    "type": "Chapter", 
    "url": "https://doi.org/10.1007/978-4-431-68399-5_5"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-4-431-68399-5_5'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-4-431-68399-5_5'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-4-431-68399-5_5'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-4-431-68399-5_5'


 

This table displays all metadata directly associated to this object as RDF triples.

191 TRIPLES      23 PREDICATES      90 URIs      83 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/978-4-431-68399-5_5 schema:about anzsrc-for:11
2 anzsrc-for:1102
3 schema:author N9232531be6b54fb1a051d8df01717a83
4 schema:datePublished 1988
5 schema:datePublishedReg 1988-01-01
6 schema:description Apical and outer wall intimas at branchings of inferior mesenteric arteries from aortas of human autopsy cases were investigated. The outer wall intima, a low shear stress region, was thicker than the apical intima, a high shear stress region, except in cases younger than one month. Deposit of ß-lipoproteins in the outer wall intima increased with age, but not that in the apical intima. Electron microscopic studies revealed that collagen fibers increased markedly in the apical intima in the third decade. Among the dense collagen fibers, intimai smooth muscle cells(SMC) exhibited contractile phenotype. The outer wall possessed mucinous intima accompanied with synthetic SMC. Atherosclerotic rabbit intimai SMC cultivated on type 1 collagen gel increased cAMP production to change phenotype from synthetic to contractile and to suppress DNA synthesis. Early lipid deposition of rabbits placed on an atherogenic diet within three weeks occurred in special linear areas of flow dividers. As a result, blood flow dynamics may induce cellular and microarchitectural changes in vessel walls which are favorable or resistant to atherogenesis.
7 schema:editor Na55d3360fbc64e89b277f8347bb4682f
8 schema:genre chapter
9 schema:inLanguage en
10 schema:isAccessibleForFree false
11 schema:isPartOf Nea2c0b986bce4d20902e6ae92c3a9e16
12 schema:keywords DNA synthesis
13 SMC
14 age
15 aorta
16 area
17 arterial wall
18 artery
19 atherogenesis
20 atherogenic diet
21 autopsy cases
22 bifurcation
23 blood flow dynamics
24 branching
25 cAMP production
26 cases
27 changes
28 collagen fibers
29 collagen gels
30 contractile phenotype
31 decades
32 dense collagen fibers
33 deposition
34 deposits
35 diet
36 divider
37 dynamics
38 early lipid deposition
39 electron microscopic study
40 fibers
41 flow divider
42 flow dynamics
43 gel
44 high shear stress regions
45 human autopsy cases
46 inferior mesenteric artery
47 intima
48 linear area
49 lipid deposition
50 lipoproteins
51 low shear stress regions
52 mesenteric artery
53 microarchitectural changes
54 microscopic study
55 months
56 morphological changes
57 muscle
58 outer wall
59 phenotype
60 production
61 rabbits
62 region
63 results
64 shear stress regions
65 smooth muscle
66 stress region
67 study
68 synthesis
69 synthetic
70 synthetic SMCs
71 third decade
72 type 1 collagen gel
73 vessel wall
74 wall
75 weeks
76 schema:name Underlying Morphological Changes in the Arterial Wall at Bifurcations for Atherogenesis
77 schema:pagination 33-40
78 schema:productId N45f09561b3564abe9a3b74e31fa7fc3b
79 N8e8ccf09d9444de3a607e08f7b4f822f
80 schema:publisher Nb688b1e6c0ca452e8efb41738a46797a
81 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021513536
82 https://doi.org/10.1007/978-4-431-68399-5_5
83 schema:sdDatePublished 2022-05-20T07:44
84 schema:sdLicense https://scigraph.springernature.com/explorer/license/
85 schema:sdPublisher N14cd236885d049518f2b3319e7317a3b
86 schema:url https://doi.org/10.1007/978-4-431-68399-5_5
87 sgo:license sg:explorer/license/
88 sgo:sdDataset chapters
89 rdf:type schema:Chapter
90 N0debf964e53b48f5b89d6e32de56418e rdf:first N9d62ae957754426fa57878434d3b70e4
91 rdf:rest N69237afe76334806bd0b665a7a6db2e2
92 N14cd236885d049518f2b3319e7317a3b schema:name Springer Nature - SN SciGraph project
93 rdf:type schema:Organization
94 N165ed95b08ad4e8b9270505d8d226283 schema:familyName Nerem
95 schema:givenName Robert M.
96 rdf:type schema:Person
97 N296c222bfa7a42f8a9192ee4249f429c schema:familyName Glagov
98 schema:givenName Seymour
99 rdf:type schema:Person
100 N2d6271a3086a4f729b007bbc60efac3e rdf:first N165ed95b08ad4e8b9270505d8d226283
101 rdf:rest rdf:nil
102 N3ef179933d9d4106921197b490867dee rdf:first N296c222bfa7a42f8a9192ee4249f429c
103 rdf:rest N2d6271a3086a4f729b007bbc60efac3e
104 N45f09561b3564abe9a3b74e31fa7fc3b schema:name doi
105 schema:value 10.1007/978-4-431-68399-5_5
106 rdf:type schema:PropertyValue
107 N4d5c4d85260c4051aa400de0dde96d4d rdf:first sg:person.013377607575.22
108 rdf:rest N8fdbb79fe73d43e488e537c49c8ae4b0
109 N62363c83ae004767846eb6a6c07d68db rdf:first Na12f96faffc149418d3e222eb3398285
110 rdf:rest N3ef179933d9d4106921197b490867dee
111 N69237afe76334806bd0b665a7a6db2e2 rdf:first sg:person.0760475461.05
112 rdf:rest Nd10e3c2f159d4b079075be91f6012e36
113 N749aa46e5c584e5d8579e7d20385c4a1 schema:familyName Yamaguchi
114 schema:givenName Takami
115 rdf:type schema:Person
116 N7f403e7057b74be8bb2f452984a12e75 rdf:first sg:person.011405362052.18
117 rdf:rest N0debf964e53b48f5b89d6e32de56418e
118 N8e8ccf09d9444de3a607e08f7b4f822f schema:name dimensions_id
119 schema:value pub.1021513536
120 rdf:type schema:PropertyValue
121 N8fdbb79fe73d43e488e537c49c8ae4b0 rdf:first sg:person.053317326.51
122 rdf:rest rdf:nil
123 N9232531be6b54fb1a051d8df01717a83 rdf:first sg:person.0111607231.02
124 rdf:rest N7f403e7057b74be8bb2f452984a12e75
125 N9a18849be7f34eaab33dc400f2cbd911 schema:familyName Yoshida
126 schema:givenName Yoji
127 rdf:type schema:Person
128 N9d62ae957754426fa57878434d3b70e4 schema:affiliation grid-institutes:grid.267500.6
129 schema:familyName Wang
130 schema:givenName S.
131 rdf:type schema:Person
132 Na12f96faffc149418d3e222eb3398285 schema:familyName Caro
133 schema:givenName Colin G.
134 rdf:type schema:Person
135 Na55d3360fbc64e89b277f8347bb4682f rdf:first N9a18849be7f34eaab33dc400f2cbd911
136 rdf:rest Nac160ab795d14bd29a585cc93ca75557
137 Nac160ab795d14bd29a585cc93ca75557 rdf:first N749aa46e5c584e5d8579e7d20385c4a1
138 rdf:rest N62363c83ae004767846eb6a6c07d68db
139 Nb688b1e6c0ca452e8efb41738a46797a schema:name Springer Nature
140 rdf:type schema:Organisation
141 Nd10e3c2f159d4b079075be91f6012e36 rdf:first sg:person.0620710407.48
142 rdf:rest N4d5c4d85260c4051aa400de0dde96d4d
143 Nea2c0b986bce4d20902e6ae92c3a9e16 schema:isbn 978-4-431-68399-5
144 978-4-431-68401-5
145 schema:name Role of Blood Flow in Atherogenesis
146 rdf:type schema:Book
147 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
148 schema:name Medical and Health Sciences
149 rdf:type schema:DefinedTerm
150 anzsrc-for:1102 schema:inDefinedTermSet anzsrc-for:
151 schema:name Cardiorespiratory Medicine and Haematology
152 rdf:type schema:DefinedTerm
153 sg:person.0111607231.02 schema:affiliation grid-institutes:grid.267500.6
154 schema:familyName Yoshida
155 schema:givenName Y.
156 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0111607231.02
157 rdf:type schema:Person
158 sg:person.011405362052.18 schema:affiliation grid-institutes:grid.267500.6
159 schema:familyName Oyama
160 schema:givenName T.
161 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011405362052.18
162 rdf:type schema:Person
163 sg:person.013377607575.22 schema:affiliation grid-institutes:grid.410796.d
164 schema:familyName Yamaguchi
165 schema:givenName T.
166 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013377607575.22
167 rdf:type schema:Person
168 sg:person.053317326.51 schema:affiliation grid-institutes:None
169 schema:familyName Ooneda
170 schema:givenName G.
171 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.053317326.51
172 rdf:type schema:Person
173 sg:person.0620710407.48 schema:affiliation grid-institutes:grid.267500.6
174 schema:familyName Mitsumata
175 schema:givenName M.
176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620710407.48
177 rdf:type schema:Person
178 sg:person.0760475461.05 schema:affiliation grid-institutes:grid.267500.6
179 schema:familyName Yamane
180 schema:givenName T.
181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0760475461.05
182 rdf:type schema:Person
183 grid-institutes:None schema:alternateName Geriatrics Research Institute and Hospital, Maebashi, 371, Japan
184 schema:name Geriatrics Research Institute and Hospital, Maebashi, 371, Japan
185 rdf:type schema:Organization
186 grid-institutes:grid.267500.6 schema:alternateName Department of Pathology, Yamanashi Medical College, 409-38, Tamaho, Japan
187 schema:name Department of Pathology, Yamanashi Medical College, 409-38, Tamaho, Japan
188 rdf:type schema:Organization
189 grid-institutes:grid.410796.d schema:alternateName Department of Vascular Physiology, National Cardiovascular Center Research Institute, Suita, 565, Japan
190 schema:name Department of Vascular Physiology, National Cardiovascular Center Research Institute, Suita, 565, Japan
191 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...