Hepatitis B and C in Patients with Hepatocellular Carcinoma in Brazil View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1994

AUTHORS

Leila M. M. B. Pereira , Sérgio Mies , Wolfgang Löscher , Regina Muzkat , Eduardo H. Pirolla , Ana O. N. Fernandes , Silvano Raia , Mohamed G. Saleh , Christopher J. Tibbs , Ian G. McFarlane , Roger Williams

ABSTRACT

The relative roles of hepatitis B (HBV) and hepatitis C (HCV) virus infections in primary liver cancer in Brazil have been established. In the present study, the prevalence of HBV and HCV infections was determined in 32 Brazilian patients with hepatocellular carcinoma (HCC), of whom 30 had elevated serum alpha-fetoprotein levels (median 285ng/ml, range 10–1380), but only 14 (44%) were found to have cirrhosis on liver biopsy. Fifteen (47%) had a history of excessive alcohol consumption (>80g/day). All patients were screened for serological markers of HBV (HBsAg, anti-HBe, anti-HBc, and anti-HBs) and of HCV (anti-HCV). Additionally, HBV-DNA was determined by a radiological molecular hybridization assay, and HCV-RNA was measured by nested polymerase chain reaction (PCR). Eight (25%) patients were found to be HBsAg- and anti-HBe- positive, five of whom were seropositive for HBV-DNA. Thirteen (41%) patients were found to have anti-HBs and/or anti-HBc. Anti-HCV was found in 8 (25%), of whom four were HCV-RNA-positive, and one had HBV coinfection (HBsAg- positive). Cirrhotic patients were significantly (P More... »

PAGES

694-696

References to SciGraph publications

Book

TITLE

Viral Hepatitis and Liver Disease

ISBN

978-4-431-68257-8
978-4-431-68255-4

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-4-431-68255-4_182

DOI

http://dx.doi.org/10.1007/978-4-431-68255-4_182

DIMENSIONS

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