HCV-positive, HIV-1-negative Mothers Transmit HCV View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1994

AUTHORS

Amy J. Weiner , Michael M. Thaler , Kevin Crawford , Joe Kansopon , Keith Ching , J. Eric Hall , Fang Hu , David Chien , Michael Houghton

ABSTRACT

Using 5′ terminal region cDNA/polymerase chain reaction (cPCR) assays for the detection of hepatitis C virus (HCV), several conflicting reports on the transmission or lack of transmission from HCV-positive, human immunodeficiency virus (HlV)-1-negative mothers to their infants have been published. We evaluated seven mother/infant pairs (one set of twins) for HCV-RNA. To unequivocally demonstrate vertical transmission from the two HCV-RNA-positive, HIV-1-negative mothers to their three HCV-RNA-positive infants (one set of twins), the hypervariable domain of the putative envelope glycoprotein E2 (E2HV) was sequenced. The data indicate that HCV is transmitted from mother to infant; that transmission most likely occurs both in utero and perinatally; and that, as previously observed in HIV-1 infections, a subset of viral variants may be selectively transmitted. More... »

PAGES

463-467

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-4-431-68255-4_118

DOI

http://dx.doi.org/10.1007/978-4-431-68255-4_118

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1030420903


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1108", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical Microbiology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1117", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Public Health and Health Services", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Chiron Corporation, 4560 Horton Street, 94608, Emeryville, CA, USA", 
          "id": "http://www.grid.ac/institutes/grid.418424.f", 
          "name": [
            "Chiron Corporation, 4560 Horton Street, 94608, Emeryville, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Weiner", 
        "givenName": "Amy J.", 
        "id": "sg:person.01113064523.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01113064523.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pediatrics, University of California, 94143, San Francisco, CA, USA", 
          "id": "http://www.grid.ac/institutes/grid.266102.1", 
          "name": [
            "Department of Pediatrics, University of California, 94143, San Francisco, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Thaler", 
        "givenName": "Michael M.", 
        "id": "sg:person.072023511.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.072023511.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chiron Corporation, 4560 Horton Street, 94608, Emeryville, CA, USA", 
          "id": "http://www.grid.ac/institutes/grid.418424.f", 
          "name": [
            "Chiron Corporation, 4560 Horton Street, 94608, Emeryville, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Crawford", 
        "givenName": "Kevin", 
        "id": "sg:person.0714747535.86", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714747535.86"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chiron Corporation, 4560 Horton Street, 94608, Emeryville, CA, USA", 
          "id": "http://www.grid.ac/institutes/grid.418424.f", 
          "name": [
            "Chiron Corporation, 4560 Horton Street, 94608, Emeryville, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kansopon", 
        "givenName": "Joe", 
        "id": "sg:person.01047530524.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01047530524.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chiron Corporation, 4560 Horton Street, 94608, Emeryville, CA, USA", 
          "id": "http://www.grid.ac/institutes/grid.418424.f", 
          "name": [
            "Chiron Corporation, 4560 Horton Street, 94608, Emeryville, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ching", 
        "givenName": "Keith", 
        "id": "sg:person.01341003262.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01341003262.92"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chiron Corporation, 4560 Horton Street, 94608, Emeryville, CA, USA", 
          "id": "http://www.grid.ac/institutes/grid.418424.f", 
          "name": [
            "Chiron Corporation, 4560 Horton Street, 94608, Emeryville, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hall", 
        "givenName": "J. Eric", 
        "id": "sg:person.01061742542.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061742542.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Pediatrics, University of California, 94143, San Francisco, CA, USA", 
          "id": "http://www.grid.ac/institutes/grid.266102.1", 
          "name": [
            "Department of Pediatrics, University of California, 94143, San Francisco, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hu", 
        "givenName": "Fang", 
        "id": "sg:person.0777740762.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777740762.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chiron Corporation, 4560 Horton Street, 94608, Emeryville, CA, USA", 
          "id": "http://www.grid.ac/institutes/grid.418424.f", 
          "name": [
            "Chiron Corporation, 4560 Horton Street, 94608, Emeryville, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chien", 
        "givenName": "David", 
        "id": "sg:person.0720610635.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0720610635.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chiron Corporation, 4560 Horton Street, 94608, Emeryville, CA, USA", 
          "id": "http://www.grid.ac/institutes/grid.418424.f", 
          "name": [
            "Chiron Corporation, 4560 Horton Street, 94608, Emeryville, CA, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Houghton", 
        "givenName": "Michael", 
        "id": "sg:person.01103152435.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01103152435.08"
        ], 
        "type": "Person"
      }
    ], 
    "datePublished": "1994", 
    "datePublishedReg": "1994-01-01", 
    "description": "Using 5\u2032 terminal region cDNA/polymerase chain reaction (cPCR) assays for the detection of hepatitis C virus (HCV), several conflicting reports on the transmission or lack of transmission from HCV-positive, human immunodeficiency virus (HlV)-1-negative mothers to their infants have been published. We evaluated seven mother/infant pairs (one set of twins) for HCV-RNA. To unequivocally demonstrate vertical transmission from the two HCV-RNA-positive, HIV-1-negative mothers to their three HCV-RNA-positive infants (one set of twins), the hypervariable domain of the putative envelope glycoprotein E2 (E2HV) was sequenced. The data indicate that HCV is transmitted from mother to infant; that transmission most likely occurs both in utero and perinatally; and that, as previously observed in HIV-1 infections, a subset of viral variants may be selectively transmitted.", 
    "editor": [
      {
        "familyName": "Nishioka", 
        "givenName": "K.", 
        "type": "Person"
      }, 
      {
        "familyName": "Suzuki", 
        "givenName": "H.", 
        "type": "Person"
      }, 
      {
        "familyName": "Mishiro", 
        "givenName": "S.", 
        "type": "Person"
      }, 
      {
        "familyName": "Oda", 
        "givenName": "T.", 
        "type": "Person"
      }
    ], 
    "genre": "chapter", 
    "id": "sg:pub.10.1007/978-4-431-68255-4_118", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": {
      "isbn": [
        "978-4-431-68257-8", 
        "978-4-431-68255-4"
      ], 
      "name": "Viral Hepatitis and Liver Disease", 
      "type": "Book"
    }, 
    "keywords": [
      "hepatitis C virus", 
      "HCV-RNA", 
      "cDNA/polymerase chain reaction", 
      "mother/infant pairs", 
      "human immunodeficiency virus", 
      "envelope glycoprotein E2", 
      "HIV-1-negative mothers", 
      "HIV-1 infection", 
      "immunodeficiency virus", 
      "infant pairs", 
      "positive infants", 
      "polymerase chain reaction", 
      "lack of transmission", 
      "glycoprotein E2", 
      "viral variants", 
      "vertical transmission", 
      "infants", 
      "chain reaction", 
      "mothers", 
      "virus", 
      "hypervariable domain", 
      "utero", 
      "infection", 
      "E2", 
      "transmission", 
      "report", 
      "subset", 
      "variants", 
      "lack", 
      "data", 
      "detection", 
      "reaction", 
      "domain", 
      "pairs", 
      "terminal region cDNA/polymerase chain reaction", 
      "region cDNA/polymerase chain reaction", 
      "C virus", 
      "putative envelope glycoprotein E2", 
      "HIV-1-negative Mothers Transmit HCV", 
      "Mothers Transmit HCV", 
      "Transmit HCV"
    ], 
    "name": "HCV-positive, HIV-1-negative Mothers Transmit HCV", 
    "pagination": "463-467", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1030420903"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/978-4-431-68255-4_118"
        ]
      }
    ], 
    "publisher": {
      "name": "Springer Nature", 
      "type": "Organisation"
    }, 
    "sameAs": [
      "https://doi.org/10.1007/978-4-431-68255-4_118", 
      "https://app.dimensions.ai/details/publication/pub.1030420903"
    ], 
    "sdDataset": "chapters", 
    "sdDatePublished": "2022-01-01T19:14", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/chapter/chapter_246.jsonl", 
    "type": "Chapter", 
    "url": "https://doi.org/10.1007/978-4-431-68255-4_118"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-4-431-68255-4_118'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-4-431-68255-4_118'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-4-431-68255-4_118'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-4-431-68255-4_118'


 

This table displays all metadata directly associated to this object as RDF triples.

179 TRIPLES      23 PREDICATES      68 URIs      60 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/978-4-431-68255-4_118 schema:about anzsrc-for:11
2 anzsrc-for:1108
3 anzsrc-for:1117
4 schema:author N502b9aaa638c4621a64abb4204149ef3
5 schema:datePublished 1994
6 schema:datePublishedReg 1994-01-01
7 schema:description Using 5′ terminal region cDNA/polymerase chain reaction (cPCR) assays for the detection of hepatitis C virus (HCV), several conflicting reports on the transmission or lack of transmission from HCV-positive, human immunodeficiency virus (HlV)-1-negative mothers to their infants have been published. We evaluated seven mother/infant pairs (one set of twins) for HCV-RNA. To unequivocally demonstrate vertical transmission from the two HCV-RNA-positive, HIV-1-negative mothers to their three HCV-RNA-positive infants (one set of twins), the hypervariable domain of the putative envelope glycoprotein E2 (E2HV) was sequenced. The data indicate that HCV is transmitted from mother to infant; that transmission most likely occurs both in utero and perinatally; and that, as previously observed in HIV-1 infections, a subset of viral variants may be selectively transmitted.
8 schema:editor N67ebe63a14be4ea28a31c0e90fd436c0
9 schema:genre chapter
10 schema:inLanguage en
11 schema:isAccessibleForFree false
12 schema:isPartOf Nb6dbca81a6504f01a7371ea9fa5b6033
13 schema:keywords C virus
14 E2
15 HCV-RNA
16 HIV-1 infection
17 HIV-1-negative Mothers Transmit HCV
18 HIV-1-negative mothers
19 Mothers Transmit HCV
20 Transmit HCV
21 cDNA/polymerase chain reaction
22 chain reaction
23 data
24 detection
25 domain
26 envelope glycoprotein E2
27 glycoprotein E2
28 hepatitis C virus
29 human immunodeficiency virus
30 hypervariable domain
31 immunodeficiency virus
32 infant pairs
33 infants
34 infection
35 lack
36 lack of transmission
37 mother/infant pairs
38 mothers
39 pairs
40 polymerase chain reaction
41 positive infants
42 putative envelope glycoprotein E2
43 reaction
44 region cDNA/polymerase chain reaction
45 report
46 subset
47 terminal region cDNA/polymerase chain reaction
48 transmission
49 utero
50 variants
51 vertical transmission
52 viral variants
53 virus
54 schema:name HCV-positive, HIV-1-negative Mothers Transmit HCV
55 schema:pagination 463-467
56 schema:productId N4d8460f9bc194e4a87aef7a3d6cd59a6
57 N871370cf0de64e37b00899dbfb7be139
58 schema:publisher Nc3e4fd9a6ee44d3692d687264e8a1c53
59 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030420903
60 https://doi.org/10.1007/978-4-431-68255-4_118
61 schema:sdDatePublished 2022-01-01T19:14
62 schema:sdLicense https://scigraph.springernature.com/explorer/license/
63 schema:sdPublisher N581c119abfe24fbbb0f68aaceef162b5
64 schema:url https://doi.org/10.1007/978-4-431-68255-4_118
65 sgo:license sg:explorer/license/
66 sgo:sdDataset chapters
67 rdf:type schema:Chapter
68 N02de8176b94e4fed9b1323e7b5fd5a95 rdf:first sg:person.0777740762.31
69 rdf:rest N478cdc389ba344d0b9dbbef4c5f9d3c8
70 N354ec941843748668d4870decfa13834 rdf:first sg:person.01047530524.34
71 rdf:rest N5db3dd9723024561b296c90fe3a37d8f
72 N478cdc389ba344d0b9dbbef4c5f9d3c8 rdf:first sg:person.0720610635.31
73 rdf:rest Nd787daed2f4b4b779bd5577743a44ca3
74 N4d8460f9bc194e4a87aef7a3d6cd59a6 schema:name dimensions_id
75 schema:value pub.1030420903
76 rdf:type schema:PropertyValue
77 N502b9aaa638c4621a64abb4204149ef3 rdf:first sg:person.01113064523.09
78 rdf:rest Nd1ca219f29fc4810876aa540ac5e466d
79 N57c767686de6428b87c745c67a05dd1a schema:familyName Suzuki
80 schema:givenName H.
81 rdf:type schema:Person
82 N581c119abfe24fbbb0f68aaceef162b5 schema:name Springer Nature - SN SciGraph project
83 rdf:type schema:Organization
84 N5db3dd9723024561b296c90fe3a37d8f rdf:first sg:person.01341003262.92
85 rdf:rest Nb6fd897416a34db99d8a5a44292d3d4e
86 N62d37af309d745278b6f126f3700500b rdf:first N57c767686de6428b87c745c67a05dd1a
87 rdf:rest Na030b1aac09e4567bcf5bac58e57bf2a
88 N67ebe63a14be4ea28a31c0e90fd436c0 rdf:first Nec19a4814d644fc7a4591e0e9a7f593a
89 rdf:rest N62d37af309d745278b6f126f3700500b
90 N7227475bc9a34c4e8f5919fd06d4d10d rdf:first Nc93d9420040543f896a3086e82d97c3d
91 rdf:rest rdf:nil
92 N871370cf0de64e37b00899dbfb7be139 schema:name doi
93 schema:value 10.1007/978-4-431-68255-4_118
94 rdf:type schema:PropertyValue
95 Na030b1aac09e4567bcf5bac58e57bf2a rdf:first Nd4794da7359a41c3ac284197348bb7f1
96 rdf:rest N7227475bc9a34c4e8f5919fd06d4d10d
97 Nb6dbca81a6504f01a7371ea9fa5b6033 schema:isbn 978-4-431-68255-4
98 978-4-431-68257-8
99 schema:name Viral Hepatitis and Liver Disease
100 rdf:type schema:Book
101 Nb6fd897416a34db99d8a5a44292d3d4e rdf:first sg:person.01061742542.35
102 rdf:rest N02de8176b94e4fed9b1323e7b5fd5a95
103 Nc3e4fd9a6ee44d3692d687264e8a1c53 schema:name Springer Nature
104 rdf:type schema:Organisation
105 Nc93d9420040543f896a3086e82d97c3d schema:familyName Oda
106 schema:givenName T.
107 rdf:type schema:Person
108 Nd1ca219f29fc4810876aa540ac5e466d rdf:first sg:person.072023511.91
109 rdf:rest Ne3952bb0de9d45e894847c0978ae30fa
110 Nd4794da7359a41c3ac284197348bb7f1 schema:familyName Mishiro
111 schema:givenName S.
112 rdf:type schema:Person
113 Nd787daed2f4b4b779bd5577743a44ca3 rdf:first sg:person.01103152435.08
114 rdf:rest rdf:nil
115 Ne3952bb0de9d45e894847c0978ae30fa rdf:first sg:person.0714747535.86
116 rdf:rest N354ec941843748668d4870decfa13834
117 Nec19a4814d644fc7a4591e0e9a7f593a schema:familyName Nishioka
118 schema:givenName K.
119 rdf:type schema:Person
120 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
121 schema:name Medical and Health Sciences
122 rdf:type schema:DefinedTerm
123 anzsrc-for:1108 schema:inDefinedTermSet anzsrc-for:
124 schema:name Medical Microbiology
125 rdf:type schema:DefinedTerm
126 anzsrc-for:1117 schema:inDefinedTermSet anzsrc-for:
127 schema:name Public Health and Health Services
128 rdf:type schema:DefinedTerm
129 sg:person.01047530524.34 schema:affiliation grid-institutes:grid.418424.f
130 schema:familyName Kansopon
131 schema:givenName Joe
132 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01047530524.34
133 rdf:type schema:Person
134 sg:person.01061742542.35 schema:affiliation grid-institutes:grid.418424.f
135 schema:familyName Hall
136 schema:givenName J. Eric
137 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061742542.35
138 rdf:type schema:Person
139 sg:person.01103152435.08 schema:affiliation grid-institutes:grid.418424.f
140 schema:familyName Houghton
141 schema:givenName Michael
142 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01103152435.08
143 rdf:type schema:Person
144 sg:person.01113064523.09 schema:affiliation grid-institutes:grid.418424.f
145 schema:familyName Weiner
146 schema:givenName Amy J.
147 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01113064523.09
148 rdf:type schema:Person
149 sg:person.01341003262.92 schema:affiliation grid-institutes:grid.418424.f
150 schema:familyName Ching
151 schema:givenName Keith
152 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01341003262.92
153 rdf:type schema:Person
154 sg:person.0714747535.86 schema:affiliation grid-institutes:grid.418424.f
155 schema:familyName Crawford
156 schema:givenName Kevin
157 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714747535.86
158 rdf:type schema:Person
159 sg:person.072023511.91 schema:affiliation grid-institutes:grid.266102.1
160 schema:familyName Thaler
161 schema:givenName Michael M.
162 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.072023511.91
163 rdf:type schema:Person
164 sg:person.0720610635.31 schema:affiliation grid-institutes:grid.418424.f
165 schema:familyName Chien
166 schema:givenName David
167 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0720610635.31
168 rdf:type schema:Person
169 sg:person.0777740762.31 schema:affiliation grid-institutes:grid.266102.1
170 schema:familyName Hu
171 schema:givenName Fang
172 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777740762.31
173 rdf:type schema:Person
174 grid-institutes:grid.266102.1 schema:alternateName Department of Pediatrics, University of California, 94143, San Francisco, CA, USA
175 schema:name Department of Pediatrics, University of California, 94143, San Francisco, CA, USA
176 rdf:type schema:Organization
177 grid-institutes:grid.418424.f schema:alternateName Chiron Corporation, 4560 Horton Street, 94608, Emeryville, CA, USA
178 schema:name Chiron Corporation, 4560 Horton Street, 94608, Emeryville, CA, USA
179 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...