Effects of Endogenous Nitric Oxide on Basal Vasomotor Tone and Stimulated Endothelium-Dependent Responses in the Coronary Arterial Circulation View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1993

AUTHORS

Frederick R. Cobb , Chang-Chyi Lin , Richard M. J. Palmer , Salvador Moncada , Alan Chu

ABSTRACT

This study assesses the role of nitric oxide in basal vasomotor tone and stimulated endothelium-dependent dilations in the coronary arteries of chronically-instrumented awake dogs by examining the responses to inhibiting endogenous nitric oxide formation with the specific inhibitor of nitric oxide formation, NG-monomethyl-L-arginine (L-NMMA). Basal epicardial coronary diameter (piezoelectric crystals), acetylcholine-stimulated endothelium-dependent dilation, flow induced endothelium-dependent dilation of the epicardial arteries, and phasic blood flow (Doppler probes) were recorded before, and after infusion of 5, 15, 50, and 120 mg/kg of L-NMMA. L-NMMA induced a dose-related increase in basal epicardial coronary vasomotor tone. There was an accompanying increase in aortic pressure and a decrease in heart rate. At doses ≥ 50 mg/kg, rest phasic coronary blood flow was also decreased. Left ventricular end-diastolic pressure and contractility were not significantly changed. In contrast, the flow-induced or acetylcholine-stimulated endothelium-dependent responses were attenuated approximately 50% only after infusion of the highest doses of L-NMMA (120mg/kg). The changes in basal vasomotor tone and acetylcholine-stimulated endothelium-dependent responses returned towards the control states in the presence of L-arginine (660 mg/kg). These data support the view that nitric oxide plays a significant role in modulating basal vasomotion and endothelium-dependent dilation stimulated by acetylcholine or increase in blood flow in epicardial coronary arteries and also influences the regulation of coronary blood flow during physiologic conditions. More... »

PAGES

171-181

References to SciGraph publications

Book

TITLE

Recent Advances in Coronary Circulation

ISBN

978-4-431-68251-6
978-4-431-68249-3

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-4-431-68249-3_19

DOI

http://dx.doi.org/10.1007/978-4-431-68249-3_19

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1007050821


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