Surface Fixation of Lumbrokinase via Photochemical Reaction of Azidophenyl Group View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1998

AUTHORS

Hyun Jung Kim , Yasuhide Nakayama , Jongwon Kim , Takehisa Matsuda , Byoung Goo Min

ABSTRACT

A new method for the immobilization of lumbrokinase (LK) on polymer was developed. The method is based on the photochemical reaction of the azidophenyl group, which produces a highly reactive phenylnitrene upon ultraviolet (UV) light irradiation. First, an aminated polymer, partially derivatized with a photoreactive phenyl azido group in its side chains, was coated onto a polyurethane (PU) surface. Subsequently, the surface was exposed to UV light. To induce the carboxyl group on the UV-light-treated surface, poly(methyl vinyl ether-co-maleic acid) (MAcMEC) was reacted. LK was immobilized on the PU surface using l-ethyl-3-(3-dimethylaminopropyl)carbo-diimide (EDC) in aqueous solvent. Electron spectroscopy for chemical analysis (ESCA) and water contact angle measurement before and after sequential surface reactions revealed that LK was immobilized successfully. The LK immobilized on the PU surface had fibrinolytic activity. In conclusion, LK immobilization via this photochemical reaction will be useful in improving the blood compatibility of blood-contacting polymer. More... »

PAGES

467-470

Book

TITLE

Heart Replacement

ISBN

978-4-431-65923-5
978-4-431-65921-1

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-4-431-65921-1_74

DOI

http://dx.doi.org/10.1007/978-4-431-65921-1_74

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1003851481


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0303", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Macromolecular and Materials Chemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/03", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Chemical Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Seoul National University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412484.f", 
          "name": [
            "Institute of Medical and Biomedical Engineering, Seoul National University Hospital, 28 Youngun-Dong, Chongno-Ku, Seoul, 110-744, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Hyun Jung", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Cerebral and Cardiovascular Center", 
          "id": "https://www.grid.ac/institutes/grid.410796.d", 
          "name": [
            "National Cardiovascular Center Research Institute, 5-7-1 Fujishirodai, Suita, Osaka 565, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nakayama", 
        "givenName": "Yasuhide", 
        "id": "sg:person.01004560530.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004560530.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412484.f", 
          "name": [
            "Institute of Medical and Biomedical Engineering, Seoul National University Hospital, 28 Youngun-Dong, Chongno-Ku, Seoul, 110-744, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Jongwon", 
        "id": "sg:person.013611426734.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013611426734.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Cerebral and Cardiovascular Center", 
          "id": "https://www.grid.ac/institutes/grid.410796.d", 
          "name": [
            "National Cardiovascular Center Research Institute, 5-7-1 Fujishirodai, Suita, Osaka 565, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Matsuda", 
        "givenName": "Takehisa", 
        "id": "sg:person.016364747632.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016364747632.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Seoul National University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412484.f", 
          "name": [
            "Institute of Medical and Biomedical Engineering, Seoul National University Hospital, 28 Youngun-Dong, Chongno-Ku, Seoul, 110-744, Korea"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Min", 
        "givenName": "Byoung Goo", 
        "id": "sg:person.0734612500.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734612500.12"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1002/jbm.820290315", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013800493"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0142-9612(93)90003-k", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038658839"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0003-2697(90)90459-m", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048239581"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bc00026a007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055152973"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ma00104a040", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056177697"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1998", 
    "datePublishedReg": "1998-01-01", 
    "description": "A new method for the immobilization of lumbrokinase (LK) on polymer was developed. The method is based on the photochemical reaction of the azidophenyl group, which produces a highly reactive phenylnitrene upon ultraviolet (UV) light irradiation. First, an aminated polymer, partially derivatized with a photoreactive phenyl azido group in its side chains, was coated onto a polyurethane (PU) surface. Subsequently, the surface was exposed to UV light. To induce the carboxyl group on the UV-light-treated surface, poly(methyl vinyl ether-co-maleic acid) (MAcMEC) was reacted. LK was immobilized on the PU surface using l-ethyl-3-(3-dimethylaminopropyl)carbo-diimide (EDC) in aqueous solvent. Electron spectroscopy for chemical analysis (ESCA) and water contact angle measurement before and after sequential surface reactions revealed that LK was immobilized successfully. The LK immobilized on the PU surface had fibrinolytic activity. In conclusion, LK immobilization via this photochemical reaction will be useful in improving the blood compatibility of blood-contacting polymer.", 
    "editor": [
      {
        "familyName": "Akutsu", 
        "givenName": "Tetsuzo", 
        "type": "Person"
      }, 
      {
        "familyName": "Koyanagi", 
        "givenName": "Hitoshi", 
        "type": "Person"
      }
    ], 
    "genre": "chapter", 
    "id": "sg:pub.10.1007/978-4-431-65921-1_74", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": {
      "isbn": [
        "978-4-431-65923-5", 
        "978-4-431-65921-1"
      ], 
      "name": "Heart Replacement", 
      "type": "Book"
    }, 
    "name": "Surface Fixation of Lumbrokinase via Photochemical Reaction of Azidophenyl Group", 
    "pagination": "467-470", 
    "productId": [
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/978-4-431-65921-1_74"
        ]
      }, 
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "1259a2cba25f38962b681bb21b99d4e26317943bb48462aa7c34acd42e036dcf"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1003851481"
        ]
      }
    ], 
    "publisher": {
      "location": "Tokyo", 
      "name": "Springer Japan", 
      "type": "Organisation"
    }, 
    "sameAs": [
      "https://doi.org/10.1007/978-4-431-65921-1_74", 
      "https://app.dimensions.ai/details/publication/pub.1003851481"
    ], 
    "sdDataset": "chapters", 
    "sdDatePublished": "2019-04-15T21:55", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8693_00000245.jsonl", 
    "type": "Chapter", 
    "url": "http://link.springer.com/10.1007/978-4-431-65921-1_74"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-4-431-65921-1_74'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-4-431-65921-1_74'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-4-431-65921-1_74'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-4-431-65921-1_74'


 

This table displays all metadata directly associated to this object as RDF triples.

115 TRIPLES      23 PREDICATES      32 URIs      20 LITERALS      8 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/978-4-431-65921-1_74 schema:about anzsrc-for:03
2 anzsrc-for:0303
3 schema:author Nbf6f41e5ec124fbe9caccb509fb3f4a2
4 schema:citation https://doi.org/10.1002/jbm.820290315
5 https://doi.org/10.1016/0003-2697(90)90459-m
6 https://doi.org/10.1016/0142-9612(93)90003-k
7 https://doi.org/10.1021/bc00026a007
8 https://doi.org/10.1021/ma00104a040
9 schema:datePublished 1998
10 schema:datePublishedReg 1998-01-01
11 schema:description A new method for the immobilization of lumbrokinase (LK) on polymer was developed. The method is based on the photochemical reaction of the azidophenyl group, which produces a highly reactive phenylnitrene upon ultraviolet (UV) light irradiation. First, an aminated polymer, partially derivatized with a photoreactive phenyl azido group in its side chains, was coated onto a polyurethane (PU) surface. Subsequently, the surface was exposed to UV light. To induce the carboxyl group on the UV-light-treated surface, poly(methyl vinyl ether-co-maleic acid) (MAcMEC) was reacted. LK was immobilized on the PU surface using l-ethyl-3-(3-dimethylaminopropyl)carbo-diimide (EDC) in aqueous solvent. Electron spectroscopy for chemical analysis (ESCA) and water contact angle measurement before and after sequential surface reactions revealed that LK was immobilized successfully. The LK immobilized on the PU surface had fibrinolytic activity. In conclusion, LK immobilization via this photochemical reaction will be useful in improving the blood compatibility of blood-contacting polymer.
12 schema:editor N281f78e38aec4b518832f20116ff3eb2
13 schema:genre chapter
14 schema:inLanguage en
15 schema:isAccessibleForFree false
16 schema:isPartOf Nffa1902e11ec47ef88efc54da69f12bb
17 schema:name Surface Fixation of Lumbrokinase via Photochemical Reaction of Azidophenyl Group
18 schema:pagination 467-470
19 schema:productId N706ab8ed5f5f4e42800ec9cc4769d08a
20 Nc077134924614d26b0def23b3589d672
21 Ndedcd60d28284a1799e135bcf31ed78f
22 schema:publisher Nf78dd5200c624fdfaf64856ce8b6795e
23 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003851481
24 https://doi.org/10.1007/978-4-431-65921-1_74
25 schema:sdDatePublished 2019-04-15T21:55
26 schema:sdLicense https://scigraph.springernature.com/explorer/license/
27 schema:sdPublisher N94132cda06a44908839145de7478b107
28 schema:url http://link.springer.com/10.1007/978-4-431-65921-1_74
29 sgo:license sg:explorer/license/
30 sgo:sdDataset chapters
31 rdf:type schema:Chapter
32 N1b47918f00b84098a19ec9d65014da51 rdf:first sg:person.01004560530.75
33 rdf:rest N9677e2f9df42495681bdf4478775aa01
34 N281f78e38aec4b518832f20116ff3eb2 rdf:first Ned5f9499a5ef44d1a0653f11bab96b2c
35 rdf:rest N2ca7b49fe84b49ad8d602332f44f9570
36 N2ca7b49fe84b49ad8d602332f44f9570 rdf:first N7175ae5aad5e4412a86378011b6ed764
37 rdf:rest rdf:nil
38 N6717d4e245cf4e27b9f5f40c52901b43 rdf:first sg:person.016364747632.42
39 rdf:rest N92da3c50edf14c5e84fc9694df76c48f
40 N706ab8ed5f5f4e42800ec9cc4769d08a schema:name readcube_id
41 schema:value 1259a2cba25f38962b681bb21b99d4e26317943bb48462aa7c34acd42e036dcf
42 rdf:type schema:PropertyValue
43 N7175ae5aad5e4412a86378011b6ed764 schema:familyName Koyanagi
44 schema:givenName Hitoshi
45 rdf:type schema:Person
46 N92da3c50edf14c5e84fc9694df76c48f rdf:first sg:person.0734612500.12
47 rdf:rest rdf:nil
48 N94132cda06a44908839145de7478b107 schema:name Springer Nature - SN SciGraph project
49 rdf:type schema:Organization
50 N9677e2f9df42495681bdf4478775aa01 rdf:first sg:person.013611426734.26
51 rdf:rest N6717d4e245cf4e27b9f5f40c52901b43
52 Nbf6f41e5ec124fbe9caccb509fb3f4a2 rdf:first Nd1d276642e644e16b9f29f6e23fe392a
53 rdf:rest N1b47918f00b84098a19ec9d65014da51
54 Nc077134924614d26b0def23b3589d672 schema:name dimensions_id
55 schema:value pub.1003851481
56 rdf:type schema:PropertyValue
57 Nd1d276642e644e16b9f29f6e23fe392a schema:affiliation https://www.grid.ac/institutes/grid.412484.f
58 schema:familyName Kim
59 schema:givenName Hyun Jung
60 rdf:type schema:Person
61 Ndedcd60d28284a1799e135bcf31ed78f schema:name doi
62 schema:value 10.1007/978-4-431-65921-1_74
63 rdf:type schema:PropertyValue
64 Ned5f9499a5ef44d1a0653f11bab96b2c schema:familyName Akutsu
65 schema:givenName Tetsuzo
66 rdf:type schema:Person
67 Nf78dd5200c624fdfaf64856ce8b6795e schema:location Tokyo
68 schema:name Springer Japan
69 rdf:type schema:Organisation
70 Nffa1902e11ec47ef88efc54da69f12bb schema:isbn 978-4-431-65921-1
71 978-4-431-65923-5
72 schema:name Heart Replacement
73 rdf:type schema:Book
74 anzsrc-for:03 schema:inDefinedTermSet anzsrc-for:
75 schema:name Chemical Sciences
76 rdf:type schema:DefinedTerm
77 anzsrc-for:0303 schema:inDefinedTermSet anzsrc-for:
78 schema:name Macromolecular and Materials Chemistry
79 rdf:type schema:DefinedTerm
80 sg:person.01004560530.75 schema:affiliation https://www.grid.ac/institutes/grid.410796.d
81 schema:familyName Nakayama
82 schema:givenName Yasuhide
83 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004560530.75
84 rdf:type schema:Person
85 sg:person.013611426734.26 schema:affiliation https://www.grid.ac/institutes/grid.412484.f
86 schema:familyName Kim
87 schema:givenName Jongwon
88 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013611426734.26
89 rdf:type schema:Person
90 sg:person.016364747632.42 schema:affiliation https://www.grid.ac/institutes/grid.410796.d
91 schema:familyName Matsuda
92 schema:givenName Takehisa
93 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016364747632.42
94 rdf:type schema:Person
95 sg:person.0734612500.12 schema:affiliation https://www.grid.ac/institutes/grid.412484.f
96 schema:familyName Min
97 schema:givenName Byoung Goo
98 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0734612500.12
99 rdf:type schema:Person
100 https://doi.org/10.1002/jbm.820290315 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013800493
101 rdf:type schema:CreativeWork
102 https://doi.org/10.1016/0003-2697(90)90459-m schema:sameAs https://app.dimensions.ai/details/publication/pub.1048239581
103 rdf:type schema:CreativeWork
104 https://doi.org/10.1016/0142-9612(93)90003-k schema:sameAs https://app.dimensions.ai/details/publication/pub.1038658839
105 rdf:type schema:CreativeWork
106 https://doi.org/10.1021/bc00026a007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055152973
107 rdf:type schema:CreativeWork
108 https://doi.org/10.1021/ma00104a040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056177697
109 rdf:type schema:CreativeWork
110 https://www.grid.ac/institutes/grid.410796.d schema:alternateName National Cerebral and Cardiovascular Center
111 schema:name National Cardiovascular Center Research Institute, 5-7-1 Fujishirodai, Suita, Osaka 565, Japan
112 rdf:type schema:Organization
113 https://www.grid.ac/institutes/grid.412484.f schema:alternateName Seoul National University Hospital
114 schema:name Institute of Medical and Biomedical Engineering, Seoul National University Hospital, 28 Youngun-Dong, Chongno-Ku, Seoul, 110-744, Korea
115 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...