Surface Fixation of Lumbrokinase via Photochemical Reaction of Azidophenyl Group View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1998

AUTHORS

Hyun Jung Kim , Yasuhide Nakayama , Jongwon Kim , Takehisa Matsuda , Byoung Goo Min

ABSTRACT

A new method for the immobilization of lumbrokinase (LK) on polymer was developed. The method is based on the photochemical reaction of the azidophenyl group, which produces a highly reactive phenylnitrene upon ultraviolet (UV) light irradiation. First, an aminated polymer, partially derivatized with a photoreactive phenyl azido group in its side chains, was coated onto a polyurethane (PU) surface. Subsequently, the surface was exposed to UV light. To induce the carboxyl group on the UV-light-treated surface, poly(methyl vinyl ether-co-maleic acid) (MAcMEC) was reacted. LK was immobilized on the PU surface using l-ethyl-3-(3-dimethylaminopropyl)carbo-diimide (EDC) in aqueous solvent. Electron spectroscopy for chemical analysis (ESCA) and water contact angle measurement before and after sequential surface reactions revealed that LK was immobilized successfully. The LK immobilized on the PU surface had fibrinolytic activity. In conclusion, LK immobilization via this photochemical reaction will be useful in improving the blood compatibility of blood-contacting polymer. More... »

PAGES

467-470

Book

TITLE

Heart Replacement

ISBN

978-4-431-65923-5
978-4-431-65921-1

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-4-431-65921-1_74

DOI

http://dx.doi.org/10.1007/978-4-431-65921-1_74

DIMENSIONS

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