Immobilization of Human Thrombomodulin Onto Biomaterials: Evaluation of Antithrombogenicity Using Small Dialyzer View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1996

AUTHORS

Akio Kishida , Yu-ki Akatsuka , Yasuhiro Ueno , Ikuro Maruyama , Mitsuru Akashi

ABSTRACT

Thrombomodulin (TM) is a newly described endothelial cell associated protein. In this study, focusing on the establishment of the practical evaluation of the hTM-immobilized materials, a novel testing systems for the immobilized-hTM activity were developed and studied. As the basis of immobilization, regenerated cellulose films and hollow fibers were used. Using hTM-immobilized cellulose hollow fiber, the small scale dialyzer was assembled and the its antithorombogenic effect on the human blood were studied using human blood circulation experiment. In conclusion, the immobilized hTM still has co-enzymatic activity for activation of protein C and anti-coagulant activity. We expect that hTM-immobilized biomaterials should be complement for conventional antithrombogenic biomaterials. More... »

PAGES

259-260

Book

TITLE

Advanced Biomaterials in Biomedical Engineering and Drug Delivery Systems

ISBN

978-4-431-65885-6
978-4-431-65883-2

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-4-431-65883-2_66

DOI

http://dx.doi.org/10.1007/978-4-431-65883-2_66

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1032520502


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