Preparation of Glucose-Sensitive Hydrogels by Entrapment or Copolymerization of Concanavalin a in a Glucosyloxyethyl Methacrylate Hydrogel View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1996

AUTHORS

Takashi Miyata , Atsushi Jikihara , Katsuhiko Nakamae , Tadashi Uragami , Allan S. Hoffman , Keisuke Kinomura , Masakazu Okumura

ABSTRACT

Two type of glucose-sensitive hydrogels were prepared by entrapment of Concanavalin A (ConA) in a glucosyloxyethyl methacrylate (GEMA) hydrogel and copolymerization of GEMA and modified Con.A in which double bonds were introduced. The swelling ratio of their hydrogels depended on the glucose concentration. This is due to the fact that glucose results in the dissociation of the complex between pendant glucose of GEMA and Con.A and the crosslinking density in the hydrogels decreases. Con.A leaked from the Con.A-entrapment GEMA hydrogel but didn’t from the Con.A-copolymerized GEMA hydrogel. The Con.A-copolymerized GEMA hydrogel showed the reversible swelling changes in response to a step-wise change in glucose concentration. More... »

PAGES

237-238

Book

TITLE

Advanced Biomaterials in Biomedical Engineering and Drug Delivery Systems

ISBN

978-4-431-65885-6
978-4-431-65883-2

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-4-431-65883-2_55

DOI

http://dx.doi.org/10.1007/978-4-431-65883-2_55

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1020519770


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