Anticoagulant Properties of Sulfonated Glucoside-Bearing Polymer View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1996

AUTHORS

Nobuyuki Sakamoto , Kazuya Suzuki , Akio Kishida , Mitsuru Akashi

ABSTRACT

Previously, we found that the sulfonated poly(glucosyloxyethyl methacrylate) (poly(GEMA)-sulfate), which bears sulfonated D-(+)-glucose, had anticoagulant activity. In this study, we tried to clarify the mechanism of anticoagulant activity of poly(GEMA)-sulfate. So we carried out activated partial thromboplastin time (APTT), prothrombin time (PT) and thrombin time (TT) tests to recognize the mechanism of anticoagulant activity for poly(GEMA)-sulfate. The results of these in vitro clotting tests showed that poly(GEMA)-sulfate had anticoagulant activity of which mechanism was different from that of heparin. It seems that inhibiting fibrin network formation of anticoagulant may be occurred by the entrapment of fibrinogen by poly(GEMA)-sulfate or inhibiting thrombin activity by the activation of heparin cofactor II. More... »

PAGES

219-220

Book

TITLE

Advanced Biomaterials in Biomedical Engineering and Drug Delivery Systems

ISBN

978-4-431-65885-6
978-4-431-65883-2

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-4-431-65883-2_46

DOI

http://dx.doi.org/10.1007/978-4-431-65883-2_46

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1039072609


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1114", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Paediatrics and Reproductive Medicine", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Kagoshima University", 
          "id": "https://www.grid.ac/institutes/grid.258333.c", 
          "name": [
            "Department of Applied Chemistry and Chemical Engineering, Faculty of Engineering, Kagoshima University, 1-21-40, Korimoto, Kagoshima 890, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sakamoto", 
        "givenName": "Nobuyuki", 
        "id": "sg:person.01144243202.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01144243202.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kagoshima University", 
          "id": "https://www.grid.ac/institutes/grid.258333.c", 
          "name": [
            "Department of Applied Chemistry and Chemical Engineering, Faculty of Engineering, Kagoshima University, 1-21-40, Korimoto, Kagoshima 890, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Suzuki", 
        "givenName": "Kazuya", 
        "id": "sg:person.016631176727.47", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016631176727.47"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kagoshima University", 
          "id": "https://www.grid.ac/institutes/grid.258333.c", 
          "name": [
            "Department of Applied Chemistry and Chemical Engineering, Faculty of Engineering, Kagoshima University, 1-21-40, Korimoto, Kagoshima 890, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kishida", 
        "givenName": "Akio", 
        "id": "sg:person.0714140254.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714140254.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kagoshima University", 
          "id": "https://www.grid.ac/institutes/grid.258333.c", 
          "name": [
            "Department of Applied Chemistry and Chemical Engineering, Faculty of Engineering, Kagoshima University, 1-21-40, Korimoto, Kagoshima 890, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Akashi", 
        "givenName": "Mitsuru", 
        "id": "sg:person.013674666001.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013674666001.05"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1002/app.1994.070521210", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015677453"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1996", 
    "datePublishedReg": "1996-01-01", 
    "description": "Previously, we found that the sulfonated poly(glucosyloxyethyl methacrylate) (poly(GEMA)-sulfate), which bears sulfonated D-(+)-glucose, had anticoagulant activity. In this study, we tried to clarify the mechanism of anticoagulant activity of poly(GEMA)-sulfate. So we carried out activated partial thromboplastin time (APTT), prothrombin time (PT) and thrombin time (TT) tests to recognize the mechanism of anticoagulant activity for poly(GEMA)-sulfate. The results of these in vitro clotting tests showed that poly(GEMA)-sulfate had anticoagulant activity of which mechanism was different from that of heparin. It seems that inhibiting fibrin network formation of anticoagulant may be occurred by the entrapment of fibrinogen by poly(GEMA)-sulfate or inhibiting thrombin activity by the activation of heparin cofactor II.", 
    "editor": [
      {
        "familyName": "Ogata", 
        "givenName": "Naoya", 
        "type": "Person"
      }, 
      {
        "familyName": "Kim", 
        "givenName": "Sung Wan", 
        "type": "Person"
      }, 
      {
        "familyName": "Feijen", 
        "givenName": "Jan", 
        "type": "Person"
      }, 
      {
        "familyName": "Okano", 
        "givenName": "Teruo", 
        "type": "Person"
      }
    ], 
    "genre": "chapter", 
    "id": "sg:pub.10.1007/978-4-431-65883-2_46", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": {
      "isbn": [
        "978-4-431-65885-6", 
        "978-4-431-65883-2"
      ], 
      "name": "Advanced Biomaterials in Biomedical Engineering and Drug Delivery Systems", 
      "type": "Book"
    }, 
    "name": "Anticoagulant Properties of Sulfonated Glucoside-Bearing Polymer", 
    "pagination": "219-220", 
    "productId": [
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/978-4-431-65883-2_46"
        ]
      }, 
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "ba1f503192be896e21c8a4d92ad6eb3d106772cd441b02bfcbddb10029de3f04"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1039072609"
        ]
      }
    ], 
    "publisher": {
      "location": "Tokyo", 
      "name": "Springer Japan", 
      "type": "Organisation"
    }, 
    "sameAs": [
      "https://doi.org/10.1007/978-4-431-65883-2_46", 
      "https://app.dimensions.ai/details/publication/pub.1039072609"
    ], 
    "sdDataset": "chapters", 
    "sdDatePublished": "2019-04-15T18:12", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8681_00000267.jsonl", 
    "type": "Chapter", 
    "url": "http://link.springer.com/10.1007/978-4-431-65883-2_46"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/978-4-431-65883-2_46'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/978-4-431-65883-2_46'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/978-4-431-65883-2_46'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/978-4-431-65883-2_46'


 

This table displays all metadata directly associated to this object as RDF triples.

104 TRIPLES      23 PREDICATES      28 URIs      20 LITERALS      8 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/978-4-431-65883-2_46 schema:about anzsrc-for:11
2 anzsrc-for:1114
3 schema:author N52fb1ac63b0340f494231453d60a6574
4 schema:citation https://doi.org/10.1002/app.1994.070521210
5 schema:datePublished 1996
6 schema:datePublishedReg 1996-01-01
7 schema:description Previously, we found that the sulfonated poly(glucosyloxyethyl methacrylate) (poly(GEMA)-sulfate), which bears sulfonated D-(+)-glucose, had anticoagulant activity. In this study, we tried to clarify the mechanism of anticoagulant activity of poly(GEMA)-sulfate. So we carried out activated partial thromboplastin time (APTT), prothrombin time (PT) and thrombin time (TT) tests to recognize the mechanism of anticoagulant activity for poly(GEMA)-sulfate. The results of these in vitro clotting tests showed that poly(GEMA)-sulfate had anticoagulant activity of which mechanism was different from that of heparin. It seems that inhibiting fibrin network formation of anticoagulant may be occurred by the entrapment of fibrinogen by poly(GEMA)-sulfate or inhibiting thrombin activity by the activation of heparin cofactor II.
8 schema:editor Naef70635475e40a8882795bac7534e12
9 schema:genre chapter
10 schema:inLanguage en
11 schema:isAccessibleForFree false
12 schema:isPartOf Ned1e3709f2a146618632523ad2952c6e
13 schema:name Anticoagulant Properties of Sulfonated Glucoside-Bearing Polymer
14 schema:pagination 219-220
15 schema:productId N98911d7841af400ba55f60de55df61c7
16 Nbf67fcdacf304b2e8ce0c255d20dea42
17 Nd1c2b3820a7445ee9211093c0999b779
18 schema:publisher N5a338c2e69cb42de95f8f34d9a726ced
19 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039072609
20 https://doi.org/10.1007/978-4-431-65883-2_46
21 schema:sdDatePublished 2019-04-15T18:12
22 schema:sdLicense https://scigraph.springernature.com/explorer/license/
23 schema:sdPublisher N0913d7b1b29541f6abcc822d9fc49015
24 schema:url http://link.springer.com/10.1007/978-4-431-65883-2_46
25 sgo:license sg:explorer/license/
26 sgo:sdDataset chapters
27 rdf:type schema:Chapter
28 N0913d7b1b29541f6abcc822d9fc49015 schema:name Springer Nature - SN SciGraph project
29 rdf:type schema:Organization
30 N3847160c50844bf893f449b74f3efa7a schema:familyName Ogata
31 schema:givenName Naoya
32 rdf:type schema:Person
33 N43cd3ead09564d5cab4bfc0b161c22d9 schema:familyName Kim
34 schema:givenName Sung Wan
35 rdf:type schema:Person
36 N4bce35a29439465f9a908933977642a0 rdf:first sg:person.0714140254.17
37 rdf:rest Nde9bb0f2299a40afb8df0596910c5bb5
38 N52fb1ac63b0340f494231453d60a6574 rdf:first sg:person.01144243202.16
39 rdf:rest N98fa2dc1c0a64a0a8cc21f56d2610929
40 N5a338c2e69cb42de95f8f34d9a726ced schema:location Tokyo
41 schema:name Springer Japan
42 rdf:type schema:Organisation
43 N8dc59cd8725549cfac8c69852f391634 rdf:first Nc099393a7fdb4eae8b19a43e63676cec
44 rdf:rest Nf558d535ddc44951b39fcda795e8ae84
45 N98911d7841af400ba55f60de55df61c7 schema:name dimensions_id
46 schema:value pub.1039072609
47 rdf:type schema:PropertyValue
48 N98fa2dc1c0a64a0a8cc21f56d2610929 rdf:first sg:person.016631176727.47
49 rdf:rest N4bce35a29439465f9a908933977642a0
50 Na0c3dc38b8de4bc2a478624c0ba15b69 rdf:first N43cd3ead09564d5cab4bfc0b161c22d9
51 rdf:rest N8dc59cd8725549cfac8c69852f391634
52 Naef70635475e40a8882795bac7534e12 rdf:first N3847160c50844bf893f449b74f3efa7a
53 rdf:rest Na0c3dc38b8de4bc2a478624c0ba15b69
54 Nbf67fcdacf304b2e8ce0c255d20dea42 schema:name doi
55 schema:value 10.1007/978-4-431-65883-2_46
56 rdf:type schema:PropertyValue
57 Nc099393a7fdb4eae8b19a43e63676cec schema:familyName Feijen
58 schema:givenName Jan
59 rdf:type schema:Person
60 Nd1c2b3820a7445ee9211093c0999b779 schema:name readcube_id
61 schema:value ba1f503192be896e21c8a4d92ad6eb3d106772cd441b02bfcbddb10029de3f04
62 rdf:type schema:PropertyValue
63 Nde9bb0f2299a40afb8df0596910c5bb5 rdf:first sg:person.013674666001.05
64 rdf:rest rdf:nil
65 Ne9d49eb957954d38a14b91d380656cd8 schema:familyName Okano
66 schema:givenName Teruo
67 rdf:type schema:Person
68 Ned1e3709f2a146618632523ad2952c6e schema:isbn 978-4-431-65883-2
69 978-4-431-65885-6
70 schema:name Advanced Biomaterials in Biomedical Engineering and Drug Delivery Systems
71 rdf:type schema:Book
72 Nf558d535ddc44951b39fcda795e8ae84 rdf:first Ne9d49eb957954d38a14b91d380656cd8
73 rdf:rest rdf:nil
74 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
75 schema:name Medical and Health Sciences
76 rdf:type schema:DefinedTerm
77 anzsrc-for:1114 schema:inDefinedTermSet anzsrc-for:
78 schema:name Paediatrics and Reproductive Medicine
79 rdf:type schema:DefinedTerm
80 sg:person.01144243202.16 schema:affiliation https://www.grid.ac/institutes/grid.258333.c
81 schema:familyName Sakamoto
82 schema:givenName Nobuyuki
83 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01144243202.16
84 rdf:type schema:Person
85 sg:person.013674666001.05 schema:affiliation https://www.grid.ac/institutes/grid.258333.c
86 schema:familyName Akashi
87 schema:givenName Mitsuru
88 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013674666001.05
89 rdf:type schema:Person
90 sg:person.016631176727.47 schema:affiliation https://www.grid.ac/institutes/grid.258333.c
91 schema:familyName Suzuki
92 schema:givenName Kazuya
93 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016631176727.47
94 rdf:type schema:Person
95 sg:person.0714140254.17 schema:affiliation https://www.grid.ac/institutes/grid.258333.c
96 schema:familyName Kishida
97 schema:givenName Akio
98 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714140254.17
99 rdf:type schema:Person
100 https://doi.org/10.1002/app.1994.070521210 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015677453
101 rdf:type schema:CreativeWork
102 https://www.grid.ac/institutes/grid.258333.c schema:alternateName Kagoshima University
103 schema:name Department of Applied Chemistry and Chemical Engineering, Faculty of Engineering, Kagoshima University, 1-21-40, Korimoto, Kagoshima 890, Japan
104 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...