Cell Culture Systems for Propagation of HCV View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2016

AUTHORS

Takaji Wakita

ABSTRACT

Hepatitis C virus (HCV) infection is seen worldwide and is a significant cause of severe chronic liver diseases. Recently, a large number of direct-acting antivirals (DAAs) have been developed against HCV infection, resulting in significant improvements in treatment efficacy. Rapid progress in HCV research has been largely dependent of the development of HCV culture systems and small animal infection models. In the development of HCV cell culture systems, the discovery of the JFH-1 clone, an HCV strain isolated from a fulminant hepatitis C patient, was a key finding. The JFH-1 strain was the first infectious HCV strain belonging to genotype 2a. JFH-1 replicated efficiently in cultured cell lines without acquiring adaptive mutations, providing the secretion of infectious viral particles into the culture medium. Other HCV strains, including JFH-2, that also were reported to be infectious in cultured cells. However, these other isolates proved to require adaptive mutations for replication. These infectious HCV systems has provided a powerful tool to study the viral life cycle, to construct anti-viral strategies, and to develop effective vaccines. More... »

PAGES

67-80

References to SciGraph publications

Book

TITLE

Hepatitis C Virus I

ISBN

978-4-431-56096-8
978-4-431-56098-2

From Grant

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-4-431-56098-2_4

DOI

http://dx.doi.org/10.1007/978-4-431-56098-2_4

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