Back to the Future: Nuclear Medicine Rediscovers Its Therapeutic Roots View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2016

AUTHORS

Rodney J. Hicks

ABSTRACT

Before the advent of diagnostic imaging, nuclear medicine was a treatment modality. The first therapeutic application of radioisotopes was almost contemporaneous with the discovery of radioactivity. P-32 became one of the first effective therapies for a range of malignant blood disorders; I-131 was established as the benchmark for the treatment of metastatic thyroid cancer; Sr-89 was recognised to provide palliative benefit in advanced prostate cancer. The development of tomographic imaging with SPECT and PET, further enhanced by hybrid CT or MRI devices, has recently focussed the speciality of nuclear medicine on the diagnostic use of isotopes. Against this trend there has been renewed awareness on the ability of radiotracers to identify potential therapeutic targets and to use this information to select patients for and to monitor the efficacy of targeted therapies using radioisotopes. This process has been termed “theranostics”. A significant factor in the rebirth of therapeutic nuclear medicine has been the development of peptides labelled with Ga-68 and Lu-177. Ga-68 DOTA-octreotate PET/CT and Lu-177 DOTA-octreotate peptide receptor radionuclide therapy (PRRT) provides the modern prototype of the theranostic paradigm. Experience with PRRT has, however, emphasised the need for a more rigorous scientific approach to radionuclide therapy. The future holds promise of wide range of therapeutic options based on diagnostic/therapeutic pairs including I-124/I-131 and Cu-64/Cu-67. Quantitative SPECT/CT and PET/CT will be key platform technologies for planning and monitoring such therapy and will realise the true promise of molecular imaging in characterising rather than just finding disease. More... »

PAGES

277-287

Book

TITLE

Perspectives on Nuclear Medicine for Molecular Diagnosis and Integrated Therapy

ISBN

978-4-431-55892-7
978-4-431-55894-1

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-4-431-55894-1_21

DOI

http://dx.doi.org/10.1007/978-4-431-55894-1_21

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1007743521


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