Structural Biology of Protein Post-transcriptional Modifications and Cellular Signaling View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2015

AUTHORS

Kazuki Kato , Hiroshi Nishimasu , Ryohei Ishii , Osamu Nureki , Ryuichiro Ishitani

ABSTRACT

Post-translational modifications play critical roles in the regulation of signal transduction and cellular functions. Structural biology methods, including X-ray crystallography, are powerful tools for dissecting the molecular interaction mechanisms among the factors involved in these signaling pathways. Therefore, synergetic approaches by structural, molecular, and cellular biology are important to understand both the mechanisms of signal transduction by post-translational modifications and their pathogenic dysregulation. In this chapter, we introduce our recent results from structural and functional analyses of proteins involved in signal transduction by the post-transcriptional modifications. In the first section, we discuss the structural analyses of cGAS, which revealed the precise mechanism of the DNA-specific conformational activation of cGAS and cGAMP production. In the second section, we discuss the structural insights of the regulation of the NF-κB pathway by A20. In the final section, we discuss the crystal structure of a dnHLH protein, HHM, in an auto-inhibited form, which adopts a characteristic V-shaped structure. These results highlight the importance of synergetic approaches by collaborations between different biological fields. More... »

PAGES

113-125

Book

TITLE

Protein Modifications in Pathogenic Dysregulation of Signaling

ISBN

978-4-431-55560-5
978-4-431-55561-2

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-4-431-55561-2_8

DOI

http://dx.doi.org/10.1007/978-4-431-55561-2_8

DIMENSIONS

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