Ontology type: schema:Chapter Open Access: True
2016
AUTHORSMohammad Khaja Mafij Uddin , Wataru Kimura , Mohammed Badrul Amin , Kasumi Nakamura , Mohammod Johirul Islam , Hiroyuki Yamagishi , Naoyuki Miura
ABSTRACTCongenital heart disease is the most common birth defects, affecting 1 % live births [1]. The cardiovascular system undergoes a series of morphogenetic events to form a heart and an aorta in fetuses. Formation of the heart and aorta requires migration, differentiation, and precise interactions among multiple cells from several embryonic origins [2]. Forkhead box2 (Foxc2) encodes a transcription factor and is expressed in mesodermal tissues, such as the pharyngeal artery, outflow tract endothelial/surrounding mesenchyme, bone, and kidney [3]. Simple knockout of Foxc2 in mouse causes an interrupted aortic arch, ventricular septal defect, cleft palate, and skeletal malformation [4]. The heart is made from primary and secondary heart field progenitors. The primary heart field gives rise to the left ventricle and atria, while the secondary heart field contributes mainly to the right ventricle and outflow tract [5] (Fig. 27.1). More... »
PAGES211-213
Etiology and Morphogenesis of Congenital Heart Disease
ISBN
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978-4-431-54628-3
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