Incapacity of 1-Methyladenine Production to Relaxin-Like Gonad-Stimulating Substance in Ca2+-Free Seawater-Treated Starfish Ovarian Follicle Cells View Full Text


Ontology type: schema:Chapter      Open Access: True


Chapter Info

DATE

2014-01-04

AUTHORS

Miho Watanabe , Kazutoshi Yamamoto , Masatoshi Mita

ABSTRACT

Previous studies have shown that brief treatment of follicle cells from ovaries of the starfish Asterina pectinifera with Ca2+-free seawater (CaFSW) deprived the follicle cells of their capacity to respond to gonad-stimulating substance (GSS). To elucidate the failure of GSS, this study examined the hormonal action of GSS on CaFSW-treated follicle cells of A. pectinifera, particularly the mode of signal transduction. GSS failed to stimulate the production of 1-methyladenine (1-MeAde) and cyclic AMP (cAMP) in CaFSW-treated follicle cells and the incapacity was irreversible. According to competitive experiments using radioiodinated and radioinert GSS, highly specific binding was observed in follicle cells, although their affinities and binding sites in CaFSW-treated follicle cells were absolutely inferior to those in intact cells. Furthermore, GSS did not stimulate adenylyl cyclase in membrane preparations of CaFSW-treated follicle cells. Both Gsα and Giα were detected immunologically in membranes of CaFSW-treated follicle cells as well as those of nontreated cells. These results suggest that signal transduction for GSS in CaFSW-treated follicle cells does not flow readily from GSS receptors to G proteins. More... »

PAGES

123-129

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-4-431-54589-7_11

DOI

http://dx.doi.org/10.1007/978-4-431-54589-7_11

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1023101634


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