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Chapter Info

DATE

2014-11-12

AUTHORS

Yoshiaki Ishigatsubo , Mitsuhiro Takeno

ABSTRACT

We review four cases of Behçet’s disease patients with serious organ involvement. Case 1 developed an aneurysm in the left subclavian artery, which was successfully treated with emergent endovascular intervention followed by infliximab. Case 2 repeated acute neurological attacks during infliximab therapy for preexisting ocular involvement. Sustained elevation of IL-6 in cerebrospinal fluid suggested transition to chronic progressive type of neuro-Behçet’s disease. Cases 3 and 4 had surgical operations for intestinal perforation of ileocecal ulcers. Case 3 needed reoperation for anastomotic leakage, while Case 4 had a third operation in spite of treatment with infliximab and adalimumab after second operation. We have learned both potent efficacy and limitation of anti-TNF therapy for BD patients.Lastly, we would like to show our trial to establish an animal model with disease susceptible genes which have been identified by genome-wide association study and subsequent investigation, leading to a novel therapeutic strategy for more appropriate targets in Behçet’s disease. More... »

PAGES

151-172

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-4-431-54487-6_9

DOI

http://dx.doi.org/10.1007/978-4-431-54487-6_9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1022250613


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