Combination of Mutanase and Dextranase Effectively Suppressed Formation of Insoluble Glucan Biofilm by Cariogenic Streptococci View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2012

AUTHORS

Hideaki Tsumori , Atsunari Shimamura , Yutaka Sakurai , Kazuo Yamakami

ABSTRACT

Cariogenic streptococci produce α-1,3-glucan and α-1,6-glucan, which are the major components of dental biofilms. To investigate the possibility of preventing dental biofilm formation, utility of a combination of mutanase and dextranase was examined in vitro. Experiments: Insoluble glucan biofilms were synthesized by cariogenic streptococci (Streptococcus mutans 10449, S. mutans Ingbritt, Streptococcus sobrinus 6715, and S. sobrinus B13) in the presence of mutanase and/or dextranase in 96-well microplates. Mutanase from Paenibacillus humicus inhibited glucan biofilm formation by these streptococci. This inhibitory effect by mutanase was enhanced in the presence of dextranase. We investigated the effect of combination of these glucosidases on the synthesis of α-1,3-glucan polysaccharides. The combination of recombinant mutanase and dextranase efficiently inhibited the synthesis of α-1,3-glucan by recombinant glucosyltransferase I on dextran-coated microplates. Conclusion: Mutanase and dextranase should be used in combination as preventive agents to inhibit dental biofilm formation. More... »

PAGES

215-217

Book

TITLE

Interface Oral Health Science 2011

ISBN

978-4-431-54069-4
978-4-431-54070-0

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-4-431-54070-0_60

DOI

http://dx.doi.org/10.1007/978-4-431-54070-0_60

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1021568857


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