Hepatitis C Virus Replication in Cell Culture View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2004

AUTHORS

Michael Frese , Volker Lohmann , Thomas Pietschmann , Artur Kaul , Nicole Krieger , Jens Bukh , Ralf Bartenschlager

ABSTRACT

By using self-replicating hepatitis C virus (HCV) RNAs, it is now possible to investigate various aspects of the viral replication cycle in cell culture. Here, we describe the construction of subgenomic and genomic replicons which replicate to high levels in the human hepatoma cell line Huh-7. Furthermore, we report and discuss recent contributions from our laboratory which has provided a better understanding of (i) HCV particle formation, (ii) the mechanisms behind the cell culture-adaptation of HCV, and (iii) the innate immune response against HCV. More... »

PAGES

108-122

Book

TITLE

Therapy for Viral Hepatitis and Prevention of Hepatocellular Carcinoma

ISBN

978-4-431-67975-2
978-4-431-53977-3

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-4-431-53977-3_11

DOI

http://dx.doi.org/10.1007/978-4-431-53977-3_11

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1021175780


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