2004
AUTHORSMichael Frese , Volker Lohmann , Thomas Pietschmann , Artur Kaul , Nicole Krieger , Jens Bukh , Ralf Bartenschlager
ABSTRACTBy using self-replicating hepatitis C virus (HCV) RNAs, it is now possible to investigate various aspects of the viral replication cycle in cell culture. Here, we describe the construction of subgenomic and genomic replicons which replicate to high levels in the human hepatoma cell line Huh-7. Furthermore, we report and discuss recent contributions from our laboratory which has provided a better understanding of (i) HCV particle formation, (ii) the mechanisms behind the cell culture-adaptation of HCV, and (iii) the innate immune response against HCV. More... »
PAGES108-122
Therapy for Viral Hepatitis and Prevention of Hepatocellular Carcinoma
ISBN
978-4-431-67975-2
978-4-431-53977-3
http://scigraph.springernature.com/pub.10.1007/978-4-431-53977-3_11
DOIhttp://dx.doi.org/10.1007/978-4-431-53977-3_11
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