Granulocyte apoptosis View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

2008

AUTHORS

Moira K. B. Whyte , Christopher Haslett , Edwin R. Chilvers

ABSTRACT

Neutrophil apoptosis (programmed cell death) is now recognised to play a fundamental role in the physiological resolution of innate immune responses. Early work by Metchnikoff correlated the ingestion of microphages (neutrophils) by macrophages with the resolution of acute inflammation, but nearly 100 years elapsed before the key role of apoptosis in determining the lifespan of granulocytes and their clearance from sites of inflammation was described [1]. Further work showed that apoptosis leads to down-regulation of neutrophil pro-inflammatory functions [2] and this, together with evidence that macrophage clearance of apoptotic granulocytes was anti-inflammatory [3], suggested that apoptosis induction could be a powerful therapeutic strategy to “turn off” neutrophilic inflammation [2]. More... »

PAGES

19-37

Book

TITLE

The Resolution of Inflammation

ISBN

978-3-7643-7505-8
978-3-7643-7506-5

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-7643-7506-5_2

DOI

http://dx.doi.org/10.1007/978-3-7643-7506-5_2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1041042517


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