Effect of Barrier Opening on Brain Edema in Human Brain Tumors View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1994

AUTHORS

Shuzo Sato , S. Suga , K. Yunoki , B. Mihara

ABSTRACT

Blood-brain barrier (BBB) opening was carried out in 10 patients with cerebral lesions, and the MRI findings were evaluated following the barrier opening. An intra-arterial injection of 10% glycerol (4 ml/kg, 1 ~ 2 ml/s) was given as a hyperosmotic solution. T2weighted MRI was undertaken using a TOSHIBA 22A at 30 minutes after BBB opening. Barrier-opening MRI was performed 10 times in 10 patients, including 5 cases of glioblastoma multiforme, 2 cases of astrocytoma, 1 case of malignant lymphoma, 1 case of cerebral contusion and 1 case of neurinoma. The high-intensity area (HIA) was compared with that in MRI without barrier opening. Three types of changes of HIA in MRI were observed after BBB opening as follows. Type 1: Expansion of the HIA was noted in 4 of 5 cases of glioblastoma multiforme, the 1 case of malignant lymphoma and the 1 case of cerebral contusion. Type 2: Almost no change was observed in the 1 case of neurinoma. Type 3: A decrease in HIA was noted in the 2 cases of astrocytoma and in 1 case of glioblastoma multiforme.The MRI following BBB opening evidently showed 3 types of changes according to the degree of BBB disruption. Glioblastoma multiforme or contusion with a severely disrupted BBB revealed an increase in HIA following barrier opening. Benign posterior fossa neurinoma showed no change in HIA after barrier opening. Moderate malignant tumors exhibited a decrease in HIA on barrieropening MRI.It was concluded that malignant tumors have a severely damaged BBB, which is readily disrupted by osmotic barrier opening. More... »

PAGES

116-118

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-7091-9334-1_30

DOI

http://dx.doi.org/10.1007/978-3-7091-9334-1_30

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1046368777


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