Growth Factors and Receptors of Lymphocytes View Full Text


Ontology type: schema:Chapter     


Chapter Info

DATE

1987

AUTHORS

T. Kinashi , Y. Noma , Ch. Azuma , Sh. Kondo , T. Tanabe , M. Konishi , M. Kinoshita , M. Takahashi , Y. Saito , T. Ogura , H. Sabe , A. Shimizu , Y. Yaoita , T. Honjo

ABSTRACT

To understand molecular mechanisms of clonal expansion of lymphocytes we have isolated cDNA clones for two lymphokines, interleukins (IL) 4 and 5 that induce proliferation and maturation of B-lymphocytes. Structures of IL-4 and IL-5 revealed a remote homology with other lymphokines such as IL-3 and gamma-interferon. IL-4 and IL-5 were shown to affect not only B-lymphocytes but also T-lymphocytes and several other cells derived from bone marrow stem cells. We have also studied the structure and function of the IL-2 receptor: our focus was the molecular basis for the high and low affinity states of the receptor encoded by the identical cDNA. We propose the affinity conversion model that the high-affinity state of the IL-2 receptor is a ternary complex of IL-2, the IL-2 receptor, and a postulated "converter protein", which is fewer in number than the receptors. More... »

PAGES

118-25

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/978-3-7091-8945-0_16

DOI

http://dx.doi.org/10.1007/978-3-7091-8945-0_16

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1039661574

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2833074


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